The La Liga Matchday 25 slate runs from February 20-23, 2026, and it arrives at a pivotal stage of the title race. CA Osasuna will welcome Real Madrid CF. Los Blancos will be chasing another league win to protect their spot at the top of the table. Atletico Madrid will welcome RCD Espanyol at the Metropolitano.
The result of this match could influence European qualification places in the league. Meanwhile, FC Barcelona will face Levante UD at Camp Nou. They will be looking to maintain pressure on Real Madrid. Any slip from the Catalans will see them fall further down the table with their chances to catch up lessening.
For more analysis across Spain and Europe, visit our main soccer predictions and La Liga betting tips hub, but for now, scroll on for today’s best bets.
Odds from FanDuel and BetMGM, accurate as of Friday afternoon ET. La Liga lines can move quickly on matchday, so always check the latest prices before betting.
Best Bet #1 – Osasuna vs Real Madrid: Kylian Mbappe to Score Anytime
Saturday’s clash at El Sadar places Osasuna’s sturdy home form against the league’s most efficient attack. Over their last ten La Liga matches, Real Madrid have averaged above 2.1 xG per game while conceding under 0.9 xGA.
Their away profile is especially strong as they’ve collected the most away points in the division. They’re also generating a high volume of penalty-area touches through wide overloads and diagonal runs. Kylian Mbappe remains central to that attacking structure.
He has scored 23 league goals in 24 appearances. And they’re averaging over 4.0 shots per 90 minutes across his last ten matches in all competitions. His non-penalty xG per 90 remains among the highest in Spain. Meanwhile Osasuna have conceded more than 1.4 xGA in four of their last six league fixtures against top-five opposition.
Their defensive block is compact but it can be stretched by pace in behind, especially when full-backs push forward. Mbappe’s pace and timing of central runs are precisely the profile that exploits those spaces. So, Mbappe getting on the scoresheet seems to be a justified pick.
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Best Bet #2 – Atletico Madrid vs Espanyol: BTTS: Yes
Sunday’s meeting at the Metropolitano sees Atletico Madrid confront an Espanyol side chasing European qualification. Atletico’s last ten league matches have produced over 1.7 xG per game. But they have also conceded in six of those outings.
While traditionally associated with defensive solidity, their recent fixtures have been more open, especially against teams willing to counter quickly. Espanyol’s away record over the same ten-game span shows over 1.3 xG generated per match.
They have scored in eight of their last ten league fixtures. Against higher-ranked opponents, Espanyol have demonstrated the ability to exploit counterattacking opportunities. Especially when opponents commit full-backs high upfield. Head-to-head records show that recent meetings between these sides have featured multiple scoring sequences rather than low-scoring stalemates.
Atletico’s home advantage remains significant, but their defensive line has allowed central shots at a higher rate this season compared to previous campaigns. So, it’s logical to think that Espanyol will be able to get in at least one goal.
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At Camp Nou, Barcelona host Levante in a fixture that on paper appears lopsided. Barcelona’s last ten La Liga matches have produced over 2.3 xG per game while conceding under 1.0 xGA. Barca rank among league leaders in shot-creating actions and progressive passes.
Meanwhile, Levante have struggled away from home. Across their previous five matches on the road, they have conceded over 1.8 xGA per game. They’ve also allowed double-digit shot totals in each outing. Against top-three opposition this season, they have found it difficult to contain overlapping runs and late midfield arrivals into the box.
Barcelona’s depth also mitigates fixture congestion concerns, as rotation options have maintained output levels in domestic matches. Considering Levante’s defensive form and Barcelona’s attacking efficiency at home, the straight win market seems logical.
La Liga Best Bets for Matchday 25 Recap – February 20-23, 2026
Best Bet #1: Osasuna vs Real Madrid – Kylian Mbappé to Score Anytime (-166 at FanDuel)
Best Bet #2: Atletico vs Espanyol – BTTS: Yes (+105 at BetMGM)
Best Bet #3: Barcelona vs Levante – Barcelona to Win (-1000 at FanDuel)
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