Mandatory Credit: Susan Mullane-Imagn Images

Daniil Medvedev vs. Reilly Opelka Head-to-Head, Prediction, and Betting Odds for ATP Citi DC Open 2025 Second Round

Medvedev opens DC campaign against big-serving Opelka in a tricky second-round test.

Mandatory Credit: Susan Mullane-Imagn Images

Eighth seed Daniil Medvedev begins his North American hard-court swing today against unseeded Reilly Opelka in the second round of the Citi DC Open. Medvedev received a first-round bye, while Opelka edged past qualifier Murphy Cassone in a tight three-setter featuring back-to-back opening tiebreaks.

Oh hey, @DaniilMedwed, welcome to DC!#MubadalaCitiDCOpen 😎 pic.twitter.com/0cq2SCfKUc
— Mubadala Citi DC Open (@mubadalacitidc) July 19, 2025

Medvedev has been a picture of consistency this season, reaching the final in Halle, where he upset Alexander Zverev before falling to Alexander Bublik, and making semifinal runs at Open 13 and Indian Wells. He’s also posted quarterfinal finishes in Doha, Dubai, Madrid, and Libema. The former world No. 1 has tallied 270 aces so far, winning 75% of first-serve points and 33% on first-serve returns, and converting 38% of 302 break-point chances.

Daniil Medvedev defeats Alexander Zverev for a 4th consecutive time (now 13-7 h2h) 7-6(3), 6-7(1), 6-4 to reach his FIRST FINAL IN 15 MONTHS (!) in Halle.

2h58

Big win.

Looking for his first title in over two years tomorrow. pic.twitter.com/YcbBuoVEak
— José Morgado (@josemorgado) June 21, 2025

Opelka’s season, by contrast, has been stop-start. He made a strong statement in Brisbane, defeating Novak Djokovic en route to the final, only to withdraw due to a wrist injury. That setback forced him out of Auckland and preceded a string of early exits. Still, he’s found good moments, with quarterfinals in Dallas and Aix-en-Provence and a semifinal in Libema.

The American has racked up 507 aces this year, winning 78% of his first-serve points, but has struggled on return, with just 21% on first-serve returns and a 31% break-point conversion rate from 120 opportunities.

Moving 🔛

After a tight contest, Reilly Opelka defeats Cassone 7-6(4) 6-7(5) 6-3. @mubadalacitidc | #MubadalaCitiDCOpen pic.twitter.com/0SskH1zclB
— ATP Tour (@atptour) July 21, 2025

Daniil Medvedev vs. Reilly Opelka Head-to-Head Record

Daniil Medvedev holds a 4-2 edge over Reilly Opelka in their head-to-head, and intriguingly, their rivalry seems to follow a curious pattern. Medvedev tends to notch two consecutive wins before Opelka responds with one of his own. And this cycle has played out twice over their six career meetings. From their first clash in Washington back in 2017 to their most recent encounter at the 2025 Libema Open, the rhythm has remained strikingly consistent.

In 2021, Medvedev dominated with back-to-back straight-set wins, one on the clay of Roland Garros and another on the hard courts of Canada. But Opelka hit back in 2025, taking their grass-court quarterfinal in ‘s-Hertogenbosch with twin tiebreaks. Notably, the only straight-set victories in this matchup have come once each for both players, Medvedev in Canada and Opelka in their latest battle, while the remaining four matches went the distance.

Year	Event	Round	Winner	Score
2025	s-Hertogenbosch	Quarterfinal	Reilly Opelka	7–6(5), 7–6(5)
2021	Canada	Final	Daniil Medvedev	6–4, 6–3
2021	Roland Garros	Round of 32	Daniil Medvedev	6–4, 6–2, 6–4
2020	St. Petersburg	Round of 16	Reilly Opelka	2–6, 7–5, 6–4
2019	Miami	Round of 32	Daniil Medvedev	7–6(5), 6–7(5), 7–6(0)
2017	Washington	Round of 64	Daniil Medvedev	6–7(8), 6–3, 7–6(6)

Daniil Medvedev vs. Reilly Opelka Comparison

Daniil Medvedev	Category	Reilly Opelka
14	Current Ranking	74
402-171	Career W-L	114-106
23-14	YTD W-L	18-14
20	Career Titles	4
1	Grand Slams	0
0	YTD Titles	0

Daniil Medvedev vs. Reilly Opelka Prediction

Medvedev enters this clash with far greater match rhythm and a more complete game. While Opelka’s serve can always keep things close, Medvedev’s consistency and superior return stats should give him the edge, especially on hard courts.

Daniil Medvedev hitting in Washington 🎾 pic.twitter.com/Cp12DlXjyP
— Mario Boccardi (@boccardi_marioo) July 20, 2025

Prediction: Daniil Medvedev in straight sets

Daniil Medvedev vs. Reilly Opelka ATP Citi DC Open 2025 Betting Odds

With Medvedev priced at 3/10, the bookmakers see him as a clear favorite, while Opelka at 5/2 offers value for those backing a big-serving upset.

Here are the betting odds according to BetMGM:

Daniil Medvedev: 3/10

Reilly Opelka: 5/2

Here are the odds for total games as well as total sets for both players (sourced via BetMGM):

Total Games Over 23.5: 49/50

Total Games Under 23.5: 4/5

Total Games won by Medvedev Over 13.5: 6/5

Total Games won by Opelka Over 11.5: 3/4

Total Sets Over 2.5: 7/5

Total Sets Under 2.5: 11/20

(According to BetMGM: BetMGM offers exclusive promo codes, bonus deals and accurate odds for users upon signing up. Use BetMGM to ace your betting game in all sports!)

Mandatory Image Credit: Susan Mullane-Imagn Images

Citi DC Open 2025

Daniil Medvedev

Reilly Opelka

Rudra Dubey

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I’m an academic turned sports writer from Raipur, India, specializing in the NFL, MMA, and tennis at The Playoffs. I previously wrote for Sportskeeda and hold a B.A. and M.A. in History. My journey into sports media began far from the field, rooted in the arts and sciences. Funny enough, I didn’t grow up a sports fan; I used to see it all as just noise. But a fateful writing job introduced me to the world of sports, and what began as a gig quickly became a passion. I understood those voices aren’t noise; they’re emotions of true sports fans, and now I am one of them, writing with the same energy I once questioned.