May 28, 2025; Paris, FR; Holger Rune of Denmark returns a shot during his match against Emilio Nava of the United States on day four at Roland Garros Stadium.

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Holger Rune vs. Alexandre Muller Preview, Prediction and Betting Odds for ATP Citi DC Open 2025 Round-2

Will the Frenchman open up the draw by upsetting the No. 3 seed?

May 28, 2025; Paris, FR; Holger Rune of Denmark returns a shot during his match against Emilio Nava of the United States on day four at Roland Garros Stadium.

Precisely three weeks ago, World No. 9 Holger Rune suffered a haunting opening round exit from Wimbledon after being up by two sets. On Tuesday, the Danish sensation will look to return to winning ways at the 2025 Mubadala Citi DC Open against Alexandre Muller of France. The Round of 32 clash will determine who progresses to the pre-quarterfinals, to face either Alex Michelsen or Daniel Evans. With the help of BetMGM, we have all the predictions and odds ready to help you place your bets.

Holger Rune vs Alexandre Muller Match Preview

Rune and Muller will be squaring off for the first time on the ATP Tour. In April, the 22-year-old prodigy made headlines when he beat Carlos Alcaraz to win the Barcelona Open trophy. Apart from this, Rune also made the final at Indian Wells. On the other hand, his French counterpart has lost his last four opening round contests coming into this match. He began the year with a title in Hong Kong, followed by a runner-up finish at Rio in February.

The 28-year-old Muller has a forgettable 1-4 record on hard courts this year. He wins 69% service games on this surface, and 15% return games. Rune, who recently stated his desire to become World No. 1, has 10 wins out of 15 hard court encounters this year. With no points to defend at this tournament, the former Top-5 starlet will be on a mission to make the most of his free swing on American soil.

The moment Alexandre Muller defeated Nishikori 2-6 6-1 6-3 to secure his maiden tour-level title 🏆@Alex2Mumu #BOCHKTO pic.twitter.com/CDscW3NVSU
— Tennis TV (@TennisTV) January 5, 2025

Holger Rune vs Alexandre Muller Career Comparison

Holger Rune	Category	Alexandre Muller
0	Grand Slams	0
5	ATP Singles Titles	1
0	ATP Doubles Titles	0
1	Masters-1000 Titles	0
–	Olympics Best Performance	–
No. 9	Current World Ranking	No. 39

Holger Rune vs Alexandre Muller ATP Citi DC Open 2025 Prediction

When it comes to striking the balance between power and variety, Rune has a better game in comparison with Muller. On paper, the Dane is likely to emerge victorious in this Round of 32 clash. Both players will look to play a patient game to endure the warm conditions at the capital over three sets. However, it is unlikely that we will witness an upset on John A Harris Grandstand.

Prediction: Holger Rune in straight sets.

Holger Rune was spotted working with Andre Agassi in Washington D.C. this weekend.

Here's what Rune had to say about their collaboration 🗣️ pic.twitter.com/5aQDTQ96Ge
— TENNIS (@Tennis) July 21, 2025

Holger Rune vs Alexandre Muller ATP Citi DC Open 2025 Betting Odds

Rune is the favourite in this match-up against underdog Muller on Tuesday. According to the implied probability on the money line, the youngster holds an advantageous 75% chance of victory. Here are all the relevant odds for the Washington war (as per BetMGM):

Holger Rune Win: 3/10
Alexandre Muller Win: 5/2

Total Games By Rune >12.5: 5/6
Total Games By Muller <11.5: 10/13
Muller +3.5 (Game Handicap): 19/20
Rune to Win 2-1: 13/6
Muller to Win At Least 1 Set (Yes): 17/20

(According to BetMGM: BetMGM offers exclusive promo codes, bonus deals and accurate odds for users upon signing up. Use BetMGM to ace your betting game in all sports!)

(Image Credits: Susan Mullane, Imagn Images)

Alexandre Muller

ATP

Betting

Citi DC Open 2025

Holger Rune

Tennis

Sankalp Harikrishnan

A passionate sports fan through and through, I am currently pursuing my MA in Global Sports Journalism. I specialise in tennis and football writing at The Playoffs News, and I have prior experience working at EssentiallySports and Sportskeeda. Born and raised in Bengaluru, India, sport was my safe space right from my childhood. After trying my hand at multiple sports and representing my educational institutions in cricket, badminton and table tennis, I found sports media to be my calling.