Mandatory Credit: Geoff Burke-Imagn Images

Naomi Osaka vs. Amanda Anisimova Head-to-Head, Preview, Prediction, and Betting Odds for US Open 2025 Semifinals

Naomi Osaka and Amanda Anisimova set for stunning US Open semifinal 2025.

Mandatory Credit: Geoff Burke-Imagn Images

Eighth seed Amanda Anisimova and 23rd seed Naomi Osaka have delivered one of the biggest surprises of the US Open 2025, storming into the semifinals against the odds. Osaka’s resurgence has been startling. The four-time Grand Slam champion snapped a years-long winless drought earlier this season in Saint Malo, but inconsistency lingered. Few predicted she would rediscover her Grand Slam magic here, yet she has done exactly that. Osaka powered past reigning Roland Garros champion Coco Gauff and 11th seed Karolina Muchova, while earlier ousting Daria Kasatkina in a gritty three-setter. Victories over Greet Minnen and Hailey Baptiste steadied her path into the second week.

Look who is back.

Naomi Osaka has returned the US Open semifinals. pic.twitter.com/qujVkuSX1X
— US Open Tennis (@usopen) September 4, 2025

For Anisimova, few expected a turnaround this sharp. Just weeks ago, she suffered the humiliation of a double-bagel defeat to Iga Swiatek at Wimbledon, a result that raised doubts about her ability to contend at the highest level. Yet in New York, she silenced critics with a stunning straight-sets upset of the second seed in the quarterfinals. Her run has also included wins over Kimberly Birrell, Maya Joint, Jaqueline Cristian, and 18th seed Beatriz Haddad Maia, showcasing her renewed confidence.

Amanda Anisimova avenges her Wimbledon loss to Swiatek less than two months ago 😤

She's headed to her first US Open Semifinal 👏 pic.twitter.com/kmht6BGl4q
— SportsCenter (@SportsCenter) September 3, 2025

The numbers underscore their form. Anisimova has played 46 matches this year with 145 aces, a 44.8 percent break conversion rate, and 65 percent of first-serve points won. Osaka, in 35 matches, has hit 226 aces, converting 44.7 percent of break points while winning an impressive 73.5 percent on first serve. Two unlikely semifinalists, both rediscovering their best tennis, now stand just one win away from the final.

Naomi Osaka vs. Amanda Anisimova Head-to-Head Record

Amanda Anisimova holds a 2-0 head-to-head lead over Naomi Osaka, with both of their encounters coming on the Grand Slam stage. Their first clash came at the 2022 Australian Open, where Anisimova edged through a tight three-set battle that featured a tiebreak. Later that same season at Roland Garros, she followed it up with a more straightforward victory in straight sets.

Year	Event	Round	Winner	Score
2022	Roland Garros	Round of 128	Amanda Anisimova	7-5, 6-4
2022	Melbourne	Round of 32	Amanda Anisimova	4-6, 6-3, 7-6(5)

Naomi Osaka vs. Amanda Anisimova Comparison

Naomi Osaka	Category	Amanda Anisimova
24	Current Ranking	9
314-178	Career W-L	194-113
27-12	YTD W-L	33-15
7	Career Titles	3
4	Grand Slams	0
0	YTD Titles	1

Naomi Osaka vs. Amanda Anisimova Prediction

With both Osaka and Anisimova surprising the court, Osaka’s proven ability to rise in big matches could give her the edge to finally return to a Grand Slam final after four and a half years.

Naomi Osaka will be back to #14 in the world when the new rankings come out.

And she could go even higher.

Coming back stronger than ever.

🇯🇵❤️ pic.twitter.com/sUEJd0WbTo
— The Tennis Letter (@TheTennisLetter) September 4, 2025

Prediction: Naomi Osaka in straight sets

Naomi Osaka vs. Amanda Anisimova US Open 2025 Betting Odds

Oddsmakers have Osaka at 22/25 and Anisimova at 49/50, making the Japanese star the narrow favorite with around a 53 percent chance of advancing.

Here are the betting odds according to BetMGM:

Naomi Osaka: 22/25

Amanda Anisimova: 49/50

Here are the odds for total games as well as total sets for both players (sourced via BetMGM):

Total Sets Under 2.5: 8/13

Total Sets Over 2.5: 13/10

Total Games Under 19.5: 37/20

Total Game Over 19.5: 21/50

Osaka Set 1 Winner: 22/25

Anisimova Set 1 Winner: 19/20

(According to BetMGM: BetMGM offers exclusive promo codes, bonus deals and accurate odds for users upon signing up. Use BetMGM to ace your betting game in all sports!)

Mandatory Image Credit: Geoff Burke-Imagn Images

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Rudra Dubey

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I’m an academic turned sports writer from Raipur, India, specializing in the NFL, MMA, and tennis at The Playoffs. I previously wrote for Sportskeeda and hold a B.A. and M.A. in History. My journey into sports media began far from the field, rooted in the arts and sciences. Funny enough, I didn’t grow up a sports fan; I used to see it all as just noise. But a fateful writing job introduced me to the world of sports, and what began as a gig quickly became a passion. I understood those voices aren’t noise; they’re emotions of true sports fans, and now I am one of them, writing with the same energy I once questioned.