Injury-hit Bucs and 49ers face off in high-stakes Week 6 clash
This Sunday’s clash between the Tampa Bay Buccaneers (4-1) and the San Francisco 49ers (4-1) at Raymond James Stadium promises to be one of the marquee matchups of Week 6. Tampa Bay comes in riding high after a thrilling 38-35 shootout win over the Seattle Seahawks, once again showing its poise in crunch-time situations. But while momentum is on their side, the challenges keep getting tougher, and this one might be their biggest test yet.
The Buccaneers have quietly turned heads across the NFC with their balanced play under pressure. Baker Mayfield has been composed and confident, leading an offense that has found rhythm despite injuries to key pieces. Tampa Bay’s passing game remains potent, and the defense has delivered in big moments. Yet facing a well-coached, physical San Francisco squad will serve as a measuring stick for how far this team has really come in the 2025 campaign.
Meanwhile, the 49ers enter Tampa off a gritty 26-23 overtime win against the Los Angeles Rams on Thursday Night Football, a victory that reinforced their status atop the bruising NFC West. Even amid mounting injuries, Kyle Shanahan’s crew continues to showcase its depth, poise, and a defense that can still change games. San Francisco has taken the last three meetings against Tampa Bay, but with the Bucs closing the gap each season, Sunday’s showdown feels less like a mismatch and more like a true NFC power battle.
Both sides have their injury concerns heading into the week. Below is a complete breakdown of the NFL Week 6 injury report for both teams ahead of this crucial Sunday matchup.
Injuries continue to test San Francisco’s depth heading into Week 6. Quarterback Brock Purdy (toe) and receiver Ricky Pearsall (knee) are both ruled out, joining a list that already includes Yetur Gross-Matos and Kevin Givens from the defensive line. The uncertainty around Jauan Jennings and Kalia Davis adds to the concern. Though Christian McCaffrey and Trent Williams are resting, Kyle Shanahan’s side must once again lean on its versatility and system discipline to stay afloat against Tampa Bay.
Recently, ESPN’s Adam Schefter reported that both wide receiver Jauan Jennings and quarterback Mac Jones are expected to suit up despite being listed as questionable earlier. Jennings has been managing an ankle and rib injury, while Jones was dealing with oblique and knee issues. However, the latest update suggests both are “expected to play,” easing concerns for the offense ahead of kickoff.
Below is the injury report for the San Francisco 49ers for Week 6 action against the Tampa Bay Buccaneers.
| Player | Position | Injury | Status |
|---|---|---|---|
| Robert Beal Jr. | DL | Ankle | Waived |
| Yetur Gross-Matos | DL | Knee/Hamstring | Out |
| Ricky Pearsall | WR | Knee | Out |
| Brock Purdy | QB | Toe | Out |
| Jordan Watkins | WR | Calf | Out |
| Kevin Givens | DL | Hand | Out |
| Alfred Collins | DL | Knee | Questionable |
| Kalia Davis | DL | Hand | Questionable |
| Upton Stout | CB | Ankle | Questionable |
| Malik Mustapha | S | Knee | Questionable |
| Christian McCaffrey | RB | Rest | – |
| Trent Williams | T | Rest | – |
| C.J. West | DL | Thumb | – |
| Kendrick Bourne | WR | Rib | – |
| Thomas Morstead | P | Back | – |
| Mykell Williams | DE | Wrist/Oblique | – |
The Buccaneers are facing one of their toughest personnel weeks of the season. Star receivers Mike Evans (hamstring) and Chris Godwin Jr. (fibula) headline a long injury list that could drastically affect Tampa’s passing game. Rookie back Bucky Irving (foot/shoulder) is also sidelined, further limiting depth on offense. Defensively, Zyon McCollum and Benjamin Morrison will miss time, while Christian Izien remains questionable. With so many key absences, Baker Mayfield’s margin for error just got narrower.
Below is the injury report for the Tampa Bay Buccaneers for Week 6 action against the San Francisco 49ers.
| Player | Position | Injury | Status |
|---|---|---|---|
| Mike Evans | WR | Hamstring | Out |
| Chris Godwin Jr. | WR | Fibula | Out |
| Bucky Irving | RB | Foot/Shoulder | Out |
| Zyon McCollum | CB | Thumb | Out |
| Benjamin Morrison | CB | Hamstring | Out |
| Josh Williams | RB | Concussion | Out |
| Christian Izien | DB | Quad | Questionable |
| Teddy Bridgewater | QB | Right shoulder | – |
| Lavonte David | LB | Knee | – |
| Jamel Dean | CB | Hip | – |
| Tristan Wirfs | T | Knee | – |
No, Ricky Pearsall will not play against the Tampa Bay Buccaneers. The rookie wide receiver has been ruled out with a knee injury, adding another blow to San Francisco’s receiving corps.
No, Brock Purdy has been ruled out for Sunday’s matchup due to a toe injury. Purdy’s absence is significant, as he’s been central to San Francisco’s rhythm and efficiency this season, leaving a major question mark under center.
No, Mike Evans has been ruled out of Sunday’s clash with a hamstring injury. The veteran wideout’s absence is a major setback for Baker Mayfield, who loses his most trusted deep-ball threat and red-zone weapon.
No, Chris Godwin Jr. is also out due to a fibula injury, compounding Tampa Bay’s offensive struggles. Basically, the Bucs are now without both of their top receivers.
Mandatory Credit: Kirby Lee-Imagn Images
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