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Broncos vs Bills Predictions, Odds, Picks & Best Bets for NFL Divisional Round

Devavrat Kulkarni

The Broncos are slight favorites at home in their Divisional round matchup against the Bills

American Football / NFL
17/01/2026 – 22:30
Denver Broncos
VS
22:30
17/01/2026
Buffalo Bills
Odds updated on January 15, 2026 at 1:23 pm

The Divisional round of the NFL season kicks off with the AFC’s number one seed, the Denver Broncos, hosting the Buffalo Bills on Saturday. This will be an interesting matchup between two teams with opposing strengths. 

To start with the home team, the Broncos are superior on the defensive side of the ball, with Sean Payton’s team leading the league in sacks (49) during the regular season. 

On the other hand, the Bills’ defense hasn’t been great, but the offense has carried the team to this point, more specifically with the performances of Josh Allen and James Cook. 

Best Bet for Denver Broncos vs Buffalo Bills

Best Bet: 

Our best bet for the Broncos vs Bills is RJ Harvey Anytime TD: (-135), (Sourced from FanDuel).

With JK Dobbins missing the final third of the season due to an injury, rookie running back RJ Harvey has taken over the Broncos’ ground game. Averaging double-digit carries in 6 of his last 7 games, Harvey has become a key part of the Broncos’ scoring options. 

With a total of 12 touchdowns this season, his dual threat ability has also been a boon for the Broncos near the endzone as he has 7 touchdowns on the ground and 5 through the air. The rookie has scored 4 touchdowns in his last 5 games. 

Additionally, the Bills are the worst team as far as allowing touchdowns on the ground. In 17 regular season games, Buffalo was tied for last place in the league, having given away 24 rushing touchdowns. 

Same-Game Parlay Picks for Broncos vs Bills

This is our pick for a 3-leg same game parlay for the Broncos vs Bills Divisional round game (Sourced from FanDuel)

  • Total Point Over 46.5: (-105)
  • Courtland Sutton 5+ Receptions: (+144)
  • James Cook Under 76.5 Rushing Yards: (-114)

Combined Odds: +609

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Total Point Over 46.5: (-105)

For the 3-leg same-game parlay, our first bet is the Over on 46.5 points. We feel this is a good bet considering both teams have high-scoring offenses. Through the 17-game regular season, the Broncos averaged 23.6 points per game, whereas the Bills put up 28.3. 

The Bills also put up 27 points against the Jacksonville Jaguars in the Wild Card game. Although Denver has one of the better defenses in the league, Josh Allen finds a way to put points on the board on the big occasions. 

Courtland Sutton 5+ Receptions: (+144)

For the second leg of the parlay, we are taking Broncos’ receiver Courtland Sutton to have 5 or more receptions in the game. The Bills’ pass defense is near mid-table, and with Sutton being the primary target for Bo Nix, there is a good possibility he will see plenty of action. 

Furthermore, Sutton has been targeted 10 or more times in 4 of his last 5 games, catching an average of nearly 6 passes in those games. 

James Cook Under 76.5 Rushing Yards: (-114) 

For the third leg, we are going with Bills’ running back James Cook rushing under 76.5 yards. Cook will be up against a strong defensive front and one of the better teams against the run. In fact, in the regular season, the Denver defense finished second in the league, allowing only 91.1 rushing yards per game. 

Cook also struggled in the Wild Card game against the Jaguars last week when he finished with just 46 yards and has not topped 75 yards in his last three games. 

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Broncos vs Bills Game Predictions by Market

Here is a look at the line, spread, and points Over/Under for the Broncos vs Bills Divisional round game, as per FanDuel.

Moneyline Prediction

The line for this game sits at (-116) for the Broncos and (-102) for the Bills. This game is expected to be a close one with neither team having an obvious advantage. The one factor in Buffalo’s favor is their recent playoff experience, which is something the Broncos aren’t too familiar with. 

Spread Prediction

The Broncos are slight favorites with a -1.5 spread over the Bills. Denver has the added advantage of extra rest as well as home-field, but that should not deter the Bills at all. Denver is also the healthier team at this moment. 

Over/Under (Total) Prediction   

The over/under for the total points in the Broncos vs Bills game is set at 46.5. On one hand, Denver’s defense is one of the best in the league, whereas the Bills’ defense is near the middle of the pack.   

However, both teams are averaging well over 20 points a game, with Denver putting up nearly 24 and Buffalo putting up around 28 a game. We are taking the Over in this one. 

Broncos vs Bills Odds

Here, we take a look at the latest Broncos vs Bills odds from a couple of our favourite sportsbooks, namely, FanDuel and BetMGM.

Spread FanDuelBetMGM
Denver Broncos-1.5 (-105)-1.5 (-103)
Buffalo Bills+1.5 (-115)+1.5 (-120)
MoneylineFanDuelBetMGM
Denver Broncos-116-110
Buffalo Bills-102-108
Total FanDuelBetMGM
Over 46.5-105-104
Under 46.5-115-117
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Trends to Know for Broncos vs Bills

  • The Broncos Over record is 4-5 at home.
  • Denver is 8-1 at home this season. 
  • Denver is 6-1 as the home favorite this year. 
  • Buffalo is 6-3 on the road this season. 
  • Buffalo is 3-0 as the underdog.
  • The Bills are 5-4 ATS on the road. 

Latest Injuries for Broncos vs Bills

There are no real injury concerns for the Broncos as linebacker Dre Greenlaw could make his return in this game. For the Bills, four players, including cornerback Maxwell Hairston, running back Ty Johnson, safety Jordan Poyer, and wide receiver Tyrell Shavers, did not practice as per the latest injury reports on Wednesday. 

Weather Report for Denver Broncos vs Buffalo Bills

As per the weather forecast by AccuWeather, the temperature is expected to be at a high of 55 degrees and a low of 35 degrees. Meteorologist Chris Bianchi of 9News expects the temperature to be around 45 degrees at the time of kick off with wind around 15-25 MPH. 

What time is the Broncos vs Bills Divisional Game?

The Divisional game between the Broncos and the Bills is slated for a late afternoon window on Saturday with kickoff at 4:30 p.m. ET. 

Where is the Broncos vs Bills game being played?

The Broncos take on the Bills in the first Divisional game on Saturday at Empower Field at Mile High in Denver, Colorado. 

How can I watch the Denver Broncos vs Buffalo Bills?

This Divisional matchup between the Broncos and the Bills will be telecast on CBS with live streaming available on Paramount+, Fubo, Hulu + Live TV, and YouTube TV (with NFL Sunday Ticket). The NFL App or NFL+ will also have streaming options for mobile users. 

The above odds are sourced from FanDuel. Use FanDuel to ace your betting game in all sports!

Mandatory Credit: Imagn Images [Corey Perrine/Florida Times-Union]

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I am a content writer for the NFL team, and joined The Playoffs after working with Sportskeeda and NFL Analysis as an NFL writer. After starting my professional career as a French-to-English translator, working as a content writer is a new adventure for me. I started out in the sports media field for two main reasons: my love for sports in general, especially the NFL, NBA, and Tennis, as well as my passion for writing. The best part of this job is that I get to write a variety of pieces with the freedom to explore content from various angles. It also enables me to stay up to date with the sporting world, which otherwise can be difficult to do in the day-to-day grind. In a world full of chaos, sports unite and entertain like nothing else!

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