Mandatory Credit: Jayne Kamin-Oncea-Imagn Images

Stefanos Tsitsipas vs. Lorenzo Musetti Head-to-Head Record, Preview and Prediction for ATP Madrid Open 2025 Round of 16

Tsitsipas and Musetti clash for ATP Madrid Open 2025 Quarterfinals

Mandatory Credit: Jayne Kamin-Oncea-Imagn Images

Stefanos Tsitsipas will be facing Lorenzo Musetti at the 2025 ATP Madrid Open’s round of 16 at the Caja Magica in Madrid, Spain. After receiving a bye in the first round, 10th seed Lorenzo Musetti and 17th seed Stefanos Tsitsipas both advanced to the second round. In that round, Musetti defeated Tomas Martin Etcheverry in straight sets, while Tsitsipas won over Jan-Lennard Struff after losing the first set.

Tsitsipas has experienced a mix of highs and lows this season, with an early exit at the Australian Open followed by a quarterfinal finish at ATP Rotterdam. He did win the Dubai Tennis Championship title, defeating Felix Auger-Aliassime in straight sets. But his form dipped afterward with back-to-back quarterfinal exits, first at the Monte Carlo Masters, upset by Musetti, and then at the Barcelona Open, losing to Arthur Fils.

Stay for the @paulabadosa reaction 😲😂@steftsitsipas books a clash with Musetti 3-6 6-4 6-3 past Struff@MutuaMadridOpen | #MMOpen pic.twitter.com/lzpm4ZBp9E
— ATP Tour (@atptour) April 26, 2025

In contrast, Musetti is in peak form, achieving a career-high ATP ranking of No. 11 after his run to the Monte Carlo Masters final. Although he lost to Carlos Alcaraz in the final, Musetti’s climb included notable wins over Alex de Minaur, Tsitsipas, and Matteo Berrettini.

Stefanos Tsitsipas vs. Lorenzo Musetti Head-to-Head Record

Stefanos Tsitsipas leads the head-to-head against Lorenzo Musetti with a record of 5-1. Their rivalry began at the 2021 Abierto Mexicano Telcel (Acapulco) semifinal, where Tsitsipas defeated Musetti in a dominant straight-set victory. A few months later, at the Open Parc Auvergne-Rhône-Alpes Lyon semifinal, Tsitsipas won again, this time in a comeback win after losing the first set.

The following year, Italian looked driven to take the lead at the French Open’s Round of 128, as Tsitsipas dropped the first two sets, but in a stunning turnaround, Tsitsipas won the next three sets. Their rivalry continued in 2023, with the Greek securing wins at both the ATP Masters 1000 Rome’s Round of 16 and the Barcelona Open Banc Sabadell semifinals.

Lorenzo Musetti becomes the first player born in 2002 to reach a Masters 1000 semifinal, defeats 3-time champ Stefanos Tsitsipas 1-6, 6-3, 6-4 to reach the last four in Monte-Carlo.

Having an incredible week.

He will face Alex De Minaur tomorrow for a place in the final. pic.twitter.com/ugwi9ZGCW5
— José Morgado (@josemorgado) April 11, 2025

However, at the 2025 ATP Masters 1000 Monte-Carlo, Musetti finally turned the tide, securing his first win over Tsitsipas in a thrilling quarterfinal, winning 6-1, 3-6, 6-4.

Year	Event	Round	Winner	Score
2025	ATP Masters 1000 Monte-Carlo	Quarterfinal	Lorenzo Musetti	6-1, 3-6, 6-4
2023	ATP Masters 1000 Rome	Round of 16	Stefanos Tsitsipas	7-5, 7-5
2023	Barcelona	Semifinal	Stefanos Tsitsipas	6-4, 5-7, 6-3
2022	Roland Garros	Round of 128	Stefanos Tsitsipas	5-7, 4-6, 6-2, 6-3, 6-2
2021	Lyon	Semifinal	Stefanos Tsitsipas	4-6, 6-3, 6-0
2021	Acapulco	Semifinal	Stefanos Tsitsipas	6-1, 6-3

Stefanos Tsitsipas vs. Lorenzo Musetti Comparison

Stefanos Tsitsipas	Category	Lorenzo Musetti
18	ATP Ranking	11
360-173	Career W-L	144-116
15-8	YTD W-L	12-5
12	Career Titles	2
0	Grand Slams	0
1	YTD Titles	0

Stefanos Tsitsipas vs. Lorenzo Musetti Prediction

Given his 118-37 career win-loss record on clay, Tsitsipas will be counting on his strong clay-court game at the Madrid Open. However, Musetti is not far behind either, as he is currently in the middle of his best season to date and has a strong 7-1 clay court record.

Prediction: Lorenzo Musetti in straight sets