Novak Djokovic vs. Francesco Maestrelli Prediction, Odds and Best Bets (Australian Open 2026, Round of 64, January 22)

24-time Grand Slam champion is hunting down another success down under.

After a dominant performance in the Round of 128 at the Australian Open 2026, 24-time Grand Slam champion Novak Djokovic faces Francesco Maestrelli of Italy on Thursday. The 38-year-old Serbian has been on the quest for an elusive 25th major for over two years, and has to navigate through a tough draw to get there. Meanwhile, Maestrelli has stunned fans at Melbourne Park with an outstanding level since the qualifying event.

Djokovic was initially slated to play the Adelaide International 2026, but pulled out due to the lack of match fitness. Yet, he looked the part in a straight sets rout of Pedro Martinez in Round-1. The World No. 4 has now achieved 100 wins at three out of the four Grand Slams, with the US Open (95) being the last one standing. In 2025, Djokovic won the Hellenic Championship in Athens, before withdrawing from the Nitto ATP Finals. He was also the runner-up in Miami, and made the semis at all the majors.

21 years difference and Novak Djokovic hasn't changed… 🤸 pic.twitter.com/kzyeTSQGYu
— TNT Sports (@tntsports) January 19, 2026

Having completed one of the best performances of his life, Maestrelli was a 6-4 3-6 6-7(4) 6-1 6-1 victor against Terence Atmane in his opener. Entering AO as the 24th seed in qualifying, three solid wins ensured a main draw entry for the 23-year-old Italian. Already his best outing at a Grand Slam, Maestrelli is certain to rise from his ranking of No. 141 in the world. He is a four-time champion on the ATP Challenger Tour as well as a two-time ITF Tour WTT winner.

According to the tennis betting odds, Novak Djokovic is the favorite with odds of -10000 on BetMGM. Francesco Maestrelli is the underdog with odds of +1500 via BetMGM. Here’s how we are betting on Djokovic vs Maestrelli at the Australian Open 2026, including our best bets, supporting odds and a set-score prop for bigger prices.

Tournament & Round: Australian Open 2026, Round of 64
Surface: Outdoor Hard Court
Format: Men’s Singles, Best of Five Sets
Date & Start Time: January 22, Not Before 13:30 Local
Court: Rod Laver Arena, Melbourne
Best Bet: Novak Djokovic 3-0 @ -285 as per BetMGM

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Novak Djokovic vs Francesco Maestrelli Betting Odds

Given below are the latest odds for Novak Djokovic vs Francesco Maestrelli from the top sportsbooks. We are looking at the match money line, game handicap and total games, plus some set betting markets where available.

Market	BetMGM	FanDuel
Moneyline	Djokovic (-10000), Maestrelli (+1500)	Djokovic (-10000), Maestrelli (+2200)
Game Handicap	Djokovic -9.5 (-107), Maestrelli +9.5 (-121)
Total Games	>27.5 (-117), <27.5 (-112)
Set Betting	Djokovic 3-0 (-285)

Novak Djokovic vs Francesco Maestrelli Prediction & Picks

Our Pick: Novak Djokovic to Win 3-0 at -285

Djokovic has an astonishing record in the second round of Grand Slams. Even in terms of ranking, the 10-time Australian Open champ is 137 spots higher than his opponent. The Italian likes to go out wide on the deuce court, and down the middle on the ad court due to the nature of his service motion. But against Djokovic, this will fall to his dominant forehand from where he hits a high percentage of return winners.

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Fatigue could also play a major role in determining the outcome of Thursday’s fixture. While Nole has only been on court for two hours, Maestrelli has already encountered four draining battles at this year’s Australian Open. With a career record of 1163-233 and over 10,000 service games played on this surface throughout his ATP stint, Djokovic is an outright favorite. Due to the one-sided look of the betting market ahead of this clash, Djokovic 3-0 becomes a best bet at -285 odds.

Novak Djokovic Recent Form

Hellenic Championship 2025: Winner
Shanghai Masters 2025: Semifinal
US Open 2025: Semifinal
Wimbledon 2025: Semifinal
Roland Garros 2025: Semifinal

Francesco Meastrelli Recent Form

Hong Kong Tennis Open 2026: Qualifying
US Open 2025: Qualifying
Wimbledon 2025: Qualifying

Novak Djokovic vs Francesco Maestrelli Head to Head Record

There is no available head-to-head record between Novak Djokovic and Francesco Maestrelli at the moment. The rivalry stands at 0-0 ahead of the Australian Open 2026 Round of 64.

How to Watch Novak Djokovic vs Francesco Maestrelli at the Australian Open 2026?

Novak Djokovic is the only player in history with 100+ Grand Slam wins on all three surfaces 💪 pic.twitter.com/AIHhSmJaUE
— TNT Sports (@tntsports) January 19, 2026

The Australian Open 2026 can be viewed live on a variety of streaming platforms and TV channels across the world. This includes Tennis Channel, Stan Sport, ESPN International, TSN, beIN Sports, SuperSport, Canal+, Sony Sports, Eurosport and TNT Sports – depending on where you are watching from.

Date	January 22, 2026
Time	Not Before 13:30 Local
Tournament	Australian Open 2026, Round of 64
Surface	Outdoor Hard Court
Court	Rod Laver Arena, Melbourne
TV/Streaming	Tennis Channel, Stan Sport, ESPN International, TSN, beIN Sports, SuperSport, Canal+, Sony Sports, Eurosport, TNT Sports

(Image Credits: Geoff Burke, Imagn Images)

Sankalp Harikrishnan

A passionate sports fan through and through, I am currently pursuing my MA in Global Sports Journalism. I specialise in tennis and football writing at The Playoffs News, and I have prior experience working at EssentiallySports and Sportskeeda. Born and raised in Bengaluru, India, sport was my safe space right from my childhood. After trying my hand at multiple sports and representing my educational institutions in cricket, badminton and table tennis, I found sports media to be my calling.

Novak Djokovic vs. Francesco Maestrelli Prediction, Odds and Best Bets (Australian Open 2026, Round of 64, January 22)

Novak Djokovic vs Francesco Maestrelli Betting Odds

Novak Djokovic vs Francesco Maestrelli Prediction & Picks

Novak Djokovic Recent Form

Francesco Meastrelli Recent Form

Novak Djokovic vs Francesco Maestrelli Head to Head Record

How to Watch Novak Djokovic vs Francesco Maestrelli at the Australian Open 2026?

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