The clash between Liverpool and Real Madrid at Anfield looms large as another marquee encounter in this season’s Champions League campaign. The Reds, after halting their domestic slide with a 2-0 win against Aston Villa, now face a Real side that could give them the fight of the season this early.
Los Blancos are currently operating like a finely-tuned machine under their former player-turned-coach. The Reds are arriving with the weight of recent inconsistency. But the loyal Anfield atmosphere may yet propel them against a Real Madrid outfit brimming with confidence and in remarkable form since the turn of the season.
| Bets | Status | Moneyline |
| Total Goals | Under 3.5 | -135 |
| Total Shots | Over 29.5 | Evens |
| Total Shots on Target | Over 9.5 | -163 |
| Total Corners | Under 10.5 | -125 |
| Total Cards | Under 4.5 | -154 |
| Liverpool Saves | Over 4.5 | +180 |
| Real Madrid Saves | Over 3.5 | +140 |
Arne Slot has greeted a welcome boost as midfielder Ryan Gravenberch returns from injury. He will provide more stability in the middle. However, major absentees remain. Goalkeeper Alisson Becker, right-back Jeremie Frimpong, and forward Alexander Isak are all expected to miss out yet again due to injuries. Meanwhile, Alexis Mac Allister and Andy Robertson should retain their places given the recent win. There’s little indication of major changes to the side that ended the domestic slump.
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Xabi Alonso’s Real Madrid continue to roll forward. However, they are short in defence. Dani Carvajal, Antonio Rudiger, and David Alaba are all sidelined due to injuries. In terms of personnel returning, Trent Alexander-Arnold is fit again. However, he is likely to start on the bench. Fede Valverde may be redeployed at right-back if Alonso doubts Alexander-Arnold’s match readiness.
Given both clubs’ statuses as heavyweight European sides, a matchup like this might suggest an open, high-scoring spectacle. But with current form and stature of the two clubs, a tight game makes more sense on closer inspection. Liverpool’s recent domestic run has been patchy despite their weekend win.
The Reds had won just two of their last eight across all competitions. Meanwhile, Real Madrid are efficient and clinical rather than free-scoring. They’ve recorded wins such as 1-0 against Juventus and 4-0 over Valencia while staying disciplined. In such a high-profile clash, expect caution, tactical discipline, and possibly a narrow margin. Hence under 3.5 goals is a realistic bet.
When it comes to standout threats, Kylian Mbappe ticks all the boxes for this prediction. He has been red-hot in front of goal. He’s currently on a scoring run that extends into eight straight La Liga matches. It’s a feat previously achieved only by Cristiano Ronaldo at Real Madrid.
Mbppe’s Champions League record remains elite, with 60 goals in 89 appearances. It places him firmly among the competition’s most lethal forwards. Given his form and the pressure on Liverpool’s defence, betting on Mbappe to score anytime at +100 holds strong value.
On the Liverpool side, Hugo Ekitike emerges as a tempting prop. The French forward joined Liverpool in the summer of 2025 after an impressive 15-goal Bundesliga season-long performance with Eintracht Frankfurt. He arrived with genuine expectation and has already shown he can contribute.
Three goals came from his first handful of appearances for the Reds. Despite Liverpool’s struggles and the formidable opposition, Ekitike’s involvement in attack by scoring or assisting, looks probable. Thus the ‘score or assist anytime’ at -110 is justified.
| Picks | Moneyline |
| Kylian Mbappe to score first | +440 |
| Hugo Ekitike to score anytime | +155 |
| Arda Guler to assist anytime | +310 |
| Alexis Mac Allister to either score or assist | +260 |
| Vinicius Jr to see a card | +160 |
| Virgil Van Dijk to foul at least once | -122 |
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Liverpool are entering this clash buoyed by their recent 2-0 win. Yet the broader context tells a more worrying story. They’re suffering from some inconsistent domestic form and lingering injuries to key players. Real Madrid, by contrast, are hitting their stride. They’re unbeaten in their Champions League group so far and leading La Liga comfortably.
Anfield may provide a platform for Liverpool to challenge. Even so, Real’s superior momentum and individual quality should carry the day. A predicted 1-2 away win feels plausible. Liverpool will push and likely find one goal, but Real should edge it by getting the decisive second.
The Liverpool vs Real Madrid Champions League clash is on November 4, 2025, at the Anfield Stadium, Liverpool, England.
Real Madrid are favorites to win with a moneyline at +145, to draw at +280 and for Liverpool to win at +155.
Kylian Mbappe to score anytime: -110
Arda Guler to assist anytime: +300
Hugo Ekitike to either score or assist: +108
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