Mandatory Credit: Aaron Doster-Imagn Images

Holger Rune vs. Botic van de Zandschulp Head-to-Head, Preview, Prediction, and Betting Odds for US Open 2025 Round – 1

Rune favored in the US Open round 1, though Zandschulp carries upset potential.

Mandatory Credit: Aaron Doster-Imagn Images

The 11th seed, Holger Rune, opens his US Open campaign against unseeded Botic van de Zandschulp in the first round. Rune’s year has swung between promise and setbacks. He reached a career-best fourth round in Melbourne before retiring in Acapulco with food poisoning. The Dane then surged to the Indian Wells final, falling to Jack Draper, and later snapped a slump with a Barcelona title run highlighted by wins over Carlos Alcaraz, Karen Khachanov, and Casper Ruud. Since then, consistency has eluded him. He withdrew from Washington with back pain but made quarterfinals in London and Cincinnati. Rune has struck 185 aces this season, winning 71% of first-serve points while converting 43% of 266 break points.

Rune 👉 R16

2024 semi-finalist @holgerrune2003 handles Michelsen 7-6 6-3. #CincyTennis pic.twitter.com/QqmhOTJtbQ
— Tennis TV (@TennisTV) August 11, 2025

Zandschulp arrives with momentum from his third career ATP final, and first on hard courts, in Winston-Salem, where he fell to Marton Fucsovics. Though results this year have otherwise been modest, with most campaigns ending in the opening rounds. Still, he owns a season highlight in upsetting Novak Djokovic at Indian Wells, alongside Challenger quarterfinals in Braunschweig and Hagen and a semifinal in Kitzbuhel. Injury withdrawals in Monte Carlo, Libema, and Bonn have disrupted his rhythm, but he remains a tricky opponent. He has delivered 132 aces, winning 72% of first serves and converting 39% of 194 break-point chances.

Got there in the end 🙌

Botic van de Zandschulp defeats Bu 6-3 5-7 6-3 and will pull double duty as he takes on Mtpetshi Perricard tonight in the semifinals!#WSOpen pic.twitter.com/Wci05XtLy1
— Tennis TV (@TennisTV) August 22, 2025

Holger Rune vs. Botic van de Zandschulp Head-to-Head Record

Holger Rune holds a 2-0 edge in his head-to-head against Botic van de Zandschulp, with both wins coming in Munich finals. Their first meeting ended abruptly when Zandschulp was forced to retire due to chest pain, giving Rune the walkover. The Dane backed it up in 2023, though, needing three sets and a tiebreak to secure the victory, a reminder that Zandschulp has the tools to make things difficult.

Year	Event	Round	Winner	Score
2023	Munich	Finals	Holger Rune	6-4, 1-6, 7-6(3)
2022	Munich	Finals	Holger Rune	3-4, Ret.

Holger Rune vs. Botic van de Zandschulp Comparison

Holger Rune	Category	Botic van de Zandschulp
11	Current Ranking	73
166-101	Career W-L	109-105
27-16	YTD W-L	14-14
5	Career Titles	0
0	Grand Slams	0
1	YTD Titles	0

Holger Rune vs. Botic van de Zandschulp Prediction

Rune’s highs and lows leave the door open, and Zandschulp’s Winston-Salem run shows he can push top players. Expect a tighter contest than the odds suggest.

Holger Rune at practice at the US Open 🎾 pic.twitter.com/sPUPRNBWMh
— Mario Boccardi (@boccardi_marioo) August 17, 2025

Prediction: Holger Rune in straight sets

Holger Rune vs. Botic van de Zandschulp US Open 2025 Betting Odds

Bookmakers back Rune at 1/3 to advance, with Zandschulp a 21/10 underdog. The numbers lean heavily toward the Dane moving on.

Here are the betting odds according to BetMGM:

Holger Rune: 1/3

Botic van de Zandschulp: 21/10

Here are the odds for total games as well as total sets for both players (sourced via BetMGM):

Total Sets Under 4.5: 7/25

Total Sets Over 4.5: 13/5

Total Games Under 34.5: 6/5

Total Game Over 34.5: 16/25

Rune Set 1 Winner: 12/25

Zandshulp Set 1 Winner: 8/5

(According to BetMGM: BetMGM offers exclusive promo codes, bonus deals and accurate odds for users upon signing up. Use BetMGM to ace your betting game in all sports!)

Mandatory image Credit: Aaron Doster-Imagn Images

Botic van de Zandschulp

Holger Rune

US Open 2025

Rudra Dubey

nfl

mma

I’m an academic turned sports writer from Raipur, India, specializing in the NFL, MMA, and tennis at The Playoffs. I previously wrote for Sportskeeda and hold a B.A. and M.A. in History. My journey into sports media began far from the field, rooted in the arts and sciences. Funny enough, I didn’t grow up a sports fan; I used to see it all as just noise. But a fateful writing job introduced me to the world of sports, and what began as a gig quickly became a passion. I understood those voices aren’t noise; they’re emotions of true sports fans, and now I am one of them, writing with the same energy I once questioned.