Liverpool will return to Champions League duty on Wednesday as they face Eintracht Frankfurt at the Deutsche Bank Park. Both sides are looking to recover from recent setbacks. Frankfurt were dismantled 5-1 by Atletico Madrid, while Liverpool fell 1-0 to Galatasaray.
Both clubs are sitting in the lower half of the league-phase standings with three points each. It makes this a crucial contest to revive their European campaigns. Frankfurt’s defensive struggles have been glaring. Meanwhile, Liverpool’s own inconsistency and leaky backline leave plenty of room for improvement.
| Bets | Status | Moneyline |
| Total Goals | Under 3.5 | -110 |
| Total Shots | Over 26.5 | -118 |
| Total Shots on Target | Over 8.5 | -182 |
| Total Corners | Under 8.5 | +125 |
| Total Cards | Under 3.5 | -125 |
| Eintracht Frankfurt Goalkeeper Total Saves | Over 4.5 | +290 |
| Liverpool Goalkeeper Total Saves | Over 3.5 | +240 |
Eintracht Frankfurt have endured a turbulent few weeks. They’ve conceded 18 goals in their last five matches and suffered four defeats in seven outings. Manager Dino Toppmoller will once again rely on teenage sensation Can Uzun. He leads the team with six goals, to provide attacking inspiration alongside striker Jonathan Burkardt.
In midfield, Ellyes Skhiri and Hugo Larsson are expected to form the double pivot. Especially since the latter is currently attracting Premier League attention. At the back, Robin Koch and Arthur Theate should continue despite recent criticism. Frankfurt are seeking to end a run of three home losses in all competitions.
Also Read: Real Madrid vs Juventus Preview, Betting Odds and Predictions – 22/10/25
Liverpool are entering this fixture following a disappointing 2-1 defeat to Manchester United and a concerning defensive trend. They’ve conceded 16 goals in 11 matches this term. Ryan Gravenberch remains doubtful with an ankle injury. That could open the door for Curtis Jones.
Alexis Mac Allister is expected to keep his place despite inconsistent form. Andrew Robertson is set to return to the starting lineup at left-back, replacing Milos Kerkez, while Joe Gomez may step in for Ibrahima Konate. Up front, Hugo Ekitike’s recent form could earn him a start ahead of Alexander Isak.
The clash between Eintracht Frankfurt and Liverpool has all the makings of a wild European evening. So, the betting market favours a tighter affair. Liverpool, despite their pedigree, arrive in Germany struggling through a four-game losing streak. Frankfurt themselves are far from solid at the back.
They’ve shipped 18 goals in their last five matches. Given both sides’ current defensive issues and tendency to concede, the suggestion is that this fixture avoids turning into a goal-fest. As such, backing fewer than 3.5 goals seems sensible given the circumstances.
The French striker Hugo Ekitike presents value for an anytime goal bet in this contest. He arrived at Liverpool after an impressive stint at Frankfurt and his familiarity with the opposition may play in his favour. Liverpool are looking to arrest their slide and Frankfurt offering more space than usual in their defence. So, Ekitike could exploit the visitors’ transitional moments. A straight-forward goal-scorer pick, he fits the profile for a key attacking moment in this match.
In much better-known territory is Mohamed Salah, who despite recent struggles still brings elite-level attacking output. His underwhelming start with three goals and three assists in 11 appearances hasn’t diminished his overall value. Even in a misfiring Liverpool side, Salah remains the go-to in match-defining moments, especially in big European ties. With Frankfurt’s defence vulnerable, the Egyptian’s ability either to finish or create a goal makes this market worth consideration.
| Picks | Moneyline |
| Hugo Ekitike to score first | +430 |
| Mohamed Salah to score anytime | -135 |
| Alexis Mac Allister to assist anytime | +350 |
| Cody Gakpo to either score or assist | -135 |
| Robin Koch to see a card | +190 |
| Arthur Theate to Commit One Foul or More | -200 |
Also Read: Chelsea vs Ajax Preview, Betting Odds and Predictions – 22/10/25
This match appears poised to be close-fought rather than one-sided. Frankfurt have shown flashes of attacking promise but remain porous at the back. They’ve conceded 18 goals in five games which shows the problem. Meanwhile, Liverpool though superior on paper, are in a lull and will likely grind out a narrow win rather than dominate.
Considering both teams’ defence issues and Liverpool’s need for a confidence-boosting result, a 2-1 away win seems the most plausible outcome. Liverpool are expected to edge it and Frankfurt to get on the scoresheet again owing to their defensive leaks. The 1-2 prediction aligns with the anticipated dynamics.
The Eintracht Frankfurt vs Liverpool Champions League clash is on October 22, 2025, at the Deutsche Bank Park, Frankfurt, Germany.
Liverpool are favorites to win with a moneyline at -175, to draw at +360 and for Eintracht Frankfurt to win at +400.
Hugo Ekitike to score anytime: -110
Florian Wirtz to assist anytime: +210
Mohamed Salah to either score or assist: -250
soccer 
