Madison Square Garden has hosted some of the most memorable fights in UFC history. The iconic venue brings out the best in fighters who understand the magnitude of competing under the bright lights. November 15 marks the promotion’s return to New York City for UFC 322, and the card is absolutely stacked from top to bottom. Two champion vs champion superfights headline the event, promising fireworks and potential upsets that could reshape multiple divisions.
Islam Makhachev (27-1)vacated his lightweight belt to chase welterweight gold against the powerful Australian champion. Meanwhile, Zhang Weili also gave up her strawweight title to challenge Valentina Shevchenko at flyweight. The main card features several crucial welterweight matchups that will determine future title challengers. Let’s break down the predictions and the betting odds for this fight card.
Here are the picks for the UFC 322 main card:
We are leaning toward Islam Makhachev despite the size jump. His elite grappling and fight IQ should translate well to welterweight. However,Della Maddalena can pull an upset based on his natural size and power advantage.
We are leaning towards Shevchenko given her experience at flyweight. Zhang’s striking prowess makes this competitive, but Valentina’s wellrounded game and championship experience give her the edge.
Brady’s wrestlingheavy style is dangerous. Morales brings dangerous striking but may struggle to keep it standing. However, Morales hits hard and Brady doesn’t respond well with getting hit. We are leaning towards Morales to win.
UFC 322 will feature 26 fighters:
— Ovin Vithanage (@OvinVithanage) November 3, 2025
🔹21 – Coming off wins
🔹14 – On win streaks
🔹9 – On 4+ win streaks
🔹4 – 4-1 in their last 5
🔹5 – 9-1 in their last 10
🔹3 – Undefeated
🔹6 – Unbeaten in the UFC
The quality of this card is insane!pic.twitter.com/WcpL4g7ZU1
We are leaning towards Prates to win. Edwards remains one of the division’s best strikers with excellent takedown defense. Prates has knockout power but faces a massive step up in competition. ‘Rocky’ has had a couple of setbacks and Prates may hold the key to win this one.
This lightweight clash features two grapplers who love to brawl. Dariush’s experience and submission skills make him the favorite, though BSD’s relentless pressure keeps things interesting. We are going with Beneil Dariush to take this one.
Here are the picks for the UFC 322 prelims and early prelims card:
Nickal’s wrestling pedigree gives him advantages everywhere. Vieira is dangerous on the ground but may struggle to get the fight there. We are going with Nickal to win
chega logo, UFC 322 pic.twitter.com/IcpIou26cg
— José Louis (@concatenarsim) November 4, 2025
A violent middleweight scrap that could end quickly. Rodrigues brings more reliable finishing ability and durability. He should walk through the fire and get his hand raised.
Blanchfield’s grappling should overwhelm Cortez once the fight hits the mat. Expect a dominant wrestling performance leading to a win for Blanchfield.
Wellmaker’s undefeated record isn’t a fluke. He’s well rounded and should handle the late replacement. We are going with Wellmaker to win.
These are two submission specialists and this makes for a chess match on the ground. Meerschaert’s experience gives him the slight edge in a competitive fight. And therefore, we are going with Meerschaert to take this one.
Sabatini’s grappling should control this fight from start to finish. Mariscal won’t have answers for the wrestling pressure. This is an easy pick for us.
Kline is younger and hungrier. Hill’s a veteran but facing a tough stylistic matchup here. We are going with Kline to win this matchup.
This one’s a good fight between two fighters looking to build their name in the UFC. Based on recent momentum and performances, we are going with Susurkaev to take this one.
Here are the current moneyline from FanDuel for the UFC 322 fight card:
Islam Makhachev (+215) vs Jack Della Maddalena (-290)
Valentina Shevchenko (-125) vs Zhang Weili (-102)
Sean Brady (-140) vs Michael Morales (+110)
Leon Edwards (+162) vs Carlos Prates (-210)
Beneil Dariush (+164) vs Benoit SaintDenis (-215)
Bo Nickal (-235) vs Rodolfo Vieira (+180)
Roman Kopylov (+130) vs Gregory Rodrigues (-166)
Erin Blanchfield (-210) vs Tracy Cortez (+162)
Malcolm Wellmaker (-150) vs Cody Haddon (+138)
Kyle Daukaus (-370) vs Gerald Meerschaert (+265)
Pat Sabatini (-136) vs Chepe Mariscal (+108)
Angela Hill (+310) vs Fatima Kline (-140)
Baisangur Susurkaev (-600) vs Eric McConico (+450)
(All odds taken from FanDuel. Bet on the most up-to-date MMA odds, lines, and spreads with FanDuel Sportsbook)
(Image Credit: Jasmin Frank – Imagn Images)
mma I am a dedicated MMA and Boxing content writer at The Playoffs. I was instantly hooked on MMA after watching the fight between Lyoto Machida vs. Gegard Mousasi back in 2014, and since then, i have been an avid writer with a deep love for the sport and its techniques, providing readers with a thorough understanding of the sport. My favorite aspect of working at The Playoffs is the creative freedom it provides. The diverse range of topics, from listicles and SEO to news articles, keeps me engaged and motivates me to continuously improve my skills! I aim to capture the excitement of the combat sports world in my writing, acting as the middleman between fighters and their die-hard fans. It is kind of like a referee, but with words!
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