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Seahawks vs Cardinals Predictions, Odds and Best Bets For Week 10 of the 2025-26 NFL Season

Devavrat Kulkarni

Seahawks favored in NFC West divisional game against the Cardinals in Week 10!

American Football / NFL
09/11/2025 – 22:05
Seattle Seahawks
VS
22:05
09/11/2025
Arizona Cardinals
Odds updated on November 7, 2025 at 12:50 pm

Seahawks vs Cardinals Predictions, Odds and Best Bets For Week 10 of the 2025-26 NFL Season

This game brings us an NFC West showdown between the Seattle Seahawks and the Arizona Cardinals. The Seahawks are currently at the top of the division with a 6-2 record. They are on a 3-game win streak, whereas the Cardinals are at the bottom of the NFC West with a 3-5 record.

Game Details:

  • Time: 4:25 p.m. ET
  • Date: Sunday, November 09, 2025
  • Location: Lumen Field, Seattle, Washington
  • TV Channel: FOX
  • Streaming: Hulu + Live TV, Fubo, and DIRECTV

Recommended bets and updated odds

Recommended BetsFanDuelBetMGM
Sam Darnold 250+ Passing Yards -144-134
Jaxon Smith-Njigba 90+ Receiving Yards-144-139
Jacoby Brissett Over 35.5 Pass Attempts-108-132
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Analysis and Rationale

Sam Darnold is currently 8th in the league with 2,084 passing yards from 8 games for an average of 260 yards per game. He has surpassed 250 passing yards in 2 of his last 3 games and has the best receiver in the game at the moment in Jaxon Smith-Njigba. Moreover, the Cardinals’ pass defense is its weak link, meaning Darnold could have a field day on Sunday.

Jaxon Smith-Njigba has been on a tear this season and is in line to cross 2,000 receiving yards by the end of the regular season. He has 6 games of over 100 receiving yards, including the last 4 in a row. 

Jacoby Brissett has attempted 35 or more pass attempts in 2 of his 3 starts so far this season. Moreover, the Seahawks’ run defense is number 2 in the league in terms of yards allowed per game, giving up a shade under 86 yards per game. A lot of the Cardinals’ offense may have to rely on Brissett and the passing game. 

Seahawks vs Cardinals Prediction

The Seattle Seahawks are playing top-quality football this season, with Jaxon Smith-Njigba a leading candidate for the offensive player of the year. Riding a 3-game win streak, the Seahawks are strong on both sides of the ball. 

Arizona, on the other hand, has struggled to win games after starting 2-0 on the year. After 5 straight losses, the Cardinals pulled off an emphatic win over the Cowboys on Monday Night Football last week, but the Seahawks will pose a much tougher challenge.  

Prediction: Seattle Seahawks to win.  

Week 10 Seahawks vs Cardinals Betting Odds and Spread

The moneyline and spread show the Seattle Seahawks are the favorites in this matchup against the Arizona Cardinals. (Sourced from FanDuel)

MoneylineSpreadTotal Points
Seattle Seahawks-300-6.5 (-115)O 44.5 (-118)
Arizona Cardinals+245+6.5 (-105)U 44.5 (-104)

Seahawks vs Cardinals Best Bets

Here are the over/under and best player bets for the Seattle Seahawks and the Arizona Cardinals, as per FanDuel.

Seattle Seahawks Over/Under Odds

Below are some of the best over/under bets for the Seattle Seahawks.

Over/ Under BetsOver Under
Sam Darnold Passing Touchdowns1.5 (-172)1.5 (+128)
Rashid Shaheed Total Receptions3.5 (+120)3.5 (-160)
Kenneth Walker III Rush Attempts12.5 (-130)12.5 (-102)
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Seattle Seahawks Best Player Bets

Below are some of the best player bets for the Seattle Seahawks.

  • Sam Darnold 250+ Passing Yards: -144
  • Jaxon Smith-Njigba 90+ Receiving Yards: -144
  • Kenneth Walker III 50+ Rushing Yards: -154

If you’re looking for a complete guide to the best NFL betting sites, we’ve got you covered 

Arizona Cardinals Over/Under Odds

Below are some of the best over/under bets for the Arizona Cardinals.

Over/ Under BetsOver Under
Jacoby Brissett Passing Touchdowns1.5 (+134)1.5 (-180)
Marvin Harrison Jr. Total Receptions4.5 (-106)4.5 (-125)
Trey McBride Total Receptions6.5 (-136)6.5 (+102)

Arizona Cardinals Best Player Bets

Below are some of the best player bets for the Arizona Cardinals.

  • Jacoby Brissett 225+ Passing Yards: -158
  • Marvin Harrison Jr. 40+ Receiving Yards: -270
  • Emari Demercado 30+ Rushing Yards: -188

The above odds are sourced from FanDuel. Use FanDuel to ace your betting game in all sports!

FAQs

What is the over/under for total points for the Seahawks vs Cardinals game?

The over/under for total points in the Seahawks vs Cardinals game is set at 44.5.

What is the point spread for the Seahawks vs Cardinals game?

The Seahawks come into the game as 6.5-point favorites over the Cardinals.

What is the moneyline for the Seahawks vs Cardinals game?

The Seahawks are the favorites with a moneyline of -300, while the Cardinals are the underdogs at +245.

Mandatory Credit: Morgan Tencza-Imagn Images

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I am a content writer for the NFL team, and joined The Playoffs after working with Sportskeeda and NFL Analysis as an NFL writer. After starting my professional career as a French-to-English translator, working as a content writer is a new adventure for me. I started out in the sports media field for two main reasons: my love for sports in general, especially the NFL, NBA, and Tennis, as well as my passion for writing. The best part of this job is that I get to write a variety of pieces with the freedom to explore content from various angles. It also enables me to stay up to date with the sporting world, which otherwise can be difficult to do in the day-to-day grind. In a world full of chaos, sports unite and entertain like nothing else!

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