Credit: @ChampionsLeague / X

Lyon vs Manchester United Europa League Head to Head: Who Holds the Edge Overall Head to Head?

Both sides will aiming to grab a crucial first-leg advantage before the return fixture at Old Trafford next week.

Credit: @ChampionsLeague / X

Manchester United head to the Groupama Stadium on Thursday night to take on Lyon in the first leg of their Europa League quarter-final clash. The Red Devils played out a goalless draw against rivals Manchester City in the Premier League on Sunday. Manchester United currently sit 13th in the Premier League, with their Europa League campaign being their last hope of securing a European spot for next season.

On the other hand, Lyon will be riding high after staging a comeback to beat Lille 2-1 in Ligue 1. Both sides will aiming to grab a crucial first-leg advantage before the return fixture at Old Trafford next week.

Quarter-finals loading 📶#MUFC || #UEL pic.twitter.com/FwGYOkkMEW
— Manchester United (@ManUtd) April 9, 2025

Lyon vs Manchester United Head to Head Record

Previous meetings: 4
Draws: 2
Man Utd wins: 2
Lyon wins: 0

ALSO READ: Andre Onana vs Nemanja Matic Ahead of the Manchester United and Lyon UEL Clash

Lyon and Manchester United have met four times in Champions League, with the Red Devils holding the edge. Manchester United have won twice and drawn the other two encounters against the French side.

Lyon vs Manchester United Recent Head to Head Scores

Home Team	Away Team	Date	Scoreline	Competition
Lyon	Manchester United	Sep 15, 2004	Lyon 2-2 Man Utd	Champions League Group Stage
Manchester United	Lyon	Nov 23, 2004	Man Utd 2-1 Lyon	Champions League Group Stage
Lyon	Manchester United	Feb 20, 2008	Lyon 1-1 Man Utd	Champions League Last 16 Second Leg
Manchester United	Lyon	Mar 04, 2008	Man Utd 1-0 Lyon	Champions League Last 16 First Leg

Lyon vs Manchester United Europa League Team News

Lyon Team News

Lyon have been dealt a significant injury setback ahead of Thursday’s clash, with winger Ernest Nuamah ruled out for the rest of the season after suffering an ACL injury during last weekend’s win over Lille. The French side will also be without Malick Fofana, who is sidelined with a knee issue. Nuamah’s absence opens the door for highly-rated forward Rayan Cherki.

Manchester United Team News

Manchester United continue to struggle with injury concerns. Lisandro Martinez (knee), Amad Diallo, Ayden Heaven (both ankle), and Jonny Evans (back) all remain unavailable, while Matthijs de Ligt (ankle) and Kobbie Mainoo (calf) will face late fitness tests.

ALSO READ: Manchester United Set Sight On Serie A Sensation in Transfer Window

Luke Shaw is back in the squad after a four-month layoff with a hamstring issue, though Patrick Dorgu is expected to keep his place at left wing-back. Harry Maguire, who was forced off early in the Manchester derby, is fit and ready to start at centre-back. Mason Mount is also in contention and could slot into midfield. Manager Ruben Amorim will have a decision to make up front, choosing between Rasmus Hojlund and Joshua Zirkzee.

🚨 Ruben has named a 23-man travelling squad for United’s trip to Lyon 📋🇫🇷#MUFC || #UEL
— Manchester United (@ManUtd) April 9, 2025

Lyon vs Manchester United Europa League Betting Odds

Odds via BetMGM.

Teams	Moneyline	Total Goals
Lyon	Win: +150 Draw: +240	Over 2.5: -121 Under 2.5: -104
Manchester United	Win: +170 Draw: +240	Over 3.5: +220 Under 3.5: -286

Europa League

Lyon

Lyon vs Manchester United

Manchester United

UEFA Europa League

Abhinav Goel

soccer

I am a soccer writer at The PlayOffs, covering everything from match analysis to transfer buzz and tactical deep dives. Ever since I was a kid, soccer has been more than just a sport to me—it’s been an obsession. Playing and watching the game from a young age fueled my passion, eventually leading me into the world of sports media and betting. Now, I get to analyze the sport I love and bring the latest updates to fans worldwide.