Aug 25, 2025; Flushing, NY, USA; Venus Williams (USA)after losing to Karolina Muchova (Czech)(not pictured) on day two of the 2025 U.S. Open tennis tournament at the USTA Billie Jean King National Tennis Center.

tennis-predictions

Leylah Fernandez/Venus Williams vs. Ekaterina Alexandrova/Shuai Zhang Preview, Prediction and Betting Odds for US Open 2025 Round of 16

The American icon is looking to win her 15th women’s doubles major.

The dream pairing of Leylah Fernandez and Venus Williams will square off against 12th seeds Ekaterina Alexandrova and Shuai Zhang in the US Open 2025 women’s doubles Round of 16. It is set to be the first time these two pairs face one another on the professional circuit. While the Canadian-American duo has stunned the Billie Jean King Tennis Center with their firepower, can they hold strong against the doubles veterans? With the help of BetMGM, we look to break down this pre-quarterfinal on Louis Armstrong Stadium.

Fernandez/Williams vs Alexandrova/Zhang Match Preview

At the age of 45, Venus Williams continues to impress the world with her passion and fighting spirit. The 14-time Grand Slam doubles champion also took part in the singles and mixed doubles events at Flushing Meadows – losing in Round-1. A three-time Olympic gold medalist in women’s doubles, she partnered Leylah Fernandez to become the star attraction this week. They upset No. 6 seeds Kichenok/Perez in Round-1, before defeating Eikeri/Hozumi in their next bout. However, their relative inexperience as a pair means that they will be the minnows on Monday.

Another Venus Williams twirl ❤️

Venus Williams and Leylah Fernandez are advancing in US Open women's doubles 👏 pic.twitter.com/0ocRioren6
— espnW (@espnW) August 30, 2025

The team of Shuai Zhang and Ekaterina Alexandrova has everything it takes for Grand Slam success. The Chinese superstar is a two-time Grand Slam champion and former World No. 2 in women’s doubles. Meanwhile, her Russian partner has improved significantly on the doubles circuit this year. Together, they are the perfect balance of fierce power and deft touch. The 12th seeds beat Cristian/Moratelli in the Round of 64. They followed it up with a thrilling three set victory over the British pairing of Boulter/Kartal.

partner props from Zhang to Alexandrova 💚#PorscheTennis pic.twitter.com/pEEGeVrV2K
— wta (@WTA) April 20, 2025

The head-to-head record between these two pairs is currently 0-0. The US Open 2025 Round of 16 will be their first meeting on tour.

Fernandez/Williams vs Alexandrova/Zhang Doubles Career Comparison

Fernandez / Williams	Category	Alexandrova / Zhang
73 / 582	Current Doubles Ranking	45 / 9
92-71 / 188-39	Career Doubles W-L Record	70-96 / 396-305
8-12 / 3-1	YTD Doubles W-L Record	14-12 / 38-17
0 / 22	Career Doubles Titles	1 / 15
0 / 0	YTD Doubles Titles	0 / 1
0 / 14	Doubles Grand Slams	0 / 2

Fernandez/Williams vs Alexandrova/Zhang US Open 2025 Prediction

A lot will depend on what time the players walk onto Louis Armstrong Stadium for this women’s doubles pre-quarterfinal. The later the time, the slower and lower it gets in terms of court conditions. While Williams and Fernandez have performed exceedingly well, there are still minor coordination issues and blips when it comes to fast-paced exchanges. With a masterful doubles specialist like Zhang handling the net and Alexandrova striking from the baseline, it will be difficult for the supposed ‘home team’ to dominate proceedings.

Prediction: Alexandrova/Zhang in three sets.

Fernandez/Williams vs Alexandrova/Zhang US Open 2025 Betting Odds

The odds are almost evenly poised for this Round of 16 battle between Fernandez/Williams and Alexandrova/Zhang. Here’s what you need to know about the match result odds (as per BetMGM):

Fernandez/Williams Win: 19/20
Alexandrova/Zhang Win: 4/5

(According to BetMGM: BetMGM offers exclusive promo codes, bonus deals and accurate odds for users upon signing up. Use BetMGM to ace your betting game in all sports!)

(Image Credits: Robert Deutsch, Imagn Images)

Betting

Ekaterina Alexandrova

Leylah Fernandez

Serena Williams

Tennis

US Open 2025

Venus Williams

WTA

Zhang Shuai

Sankalp Harikrishnan

A passionate sports fan through and through, I am currently pursuing my MA in Global Sports Journalism. I specialise in tennis and football writing at The Playoffs News, and I have prior experience working at EssentiallySports and Sportskeeda. Born and raised in Bengaluru, India, sport was my safe space right from my childhood. After trying my hand at multiple sports and representing my educational institutions in cricket, badminton and table tennis, I found sports media to be my calling.