The Jacksonville Jaguars are set to take on the Kansas City Chiefs for Week 5’s Monday Night Football, in this AFC South vs AFC West matchup. The Jaguars have surprised a lot this season, winning 3 of their first four games, only losing against the Cincinnati Bengals so far. The offseason addition have worked for them so far and they are currently sitting at 2nd place in AFC South.
Meanwhile, the Kansas City Chiefs, after a slow start to their season, are starting to come to life, winning their last two matchups against the Ravens and the Giants in Week 3 and 4. In this AFC clash, expect a low scoring game as both teams as ranked in the top 15 defensively.
| Recommended Bets | FanDuel | BetMGM |
|---|---|---|
| Travis Etienne Anytime TD scorer | +110 | -110 |
| Xavier Worthy Over 58.5 receiving yards | -114 | -110 |
| Patrick Mahomes Over 21.5 rushing yards | -114 | -118 |
We’ve tested multiple sportsbooks to create our ranking of the top NFL betting sites in 2025.
Travis Etienne Jr has been heating up in the last two games, scoring two TDs in Week 3 against the Texans, and 4 against the 49ers. The Jaguars running back also managed to get 124 yards last game on season high 19 rushing attempts last game. The Jaguars may continue to use Etienne similarly in this game against the Chiefs to keep his momentum going, and looking at the Chiefs’ 22nd ranked rush defense, we believe that Etienne can score a TD in this game.
Chiefs’ wideout Xavier Worthy made his return last game against the Ravens in Week 4 and wasted no time in making his presence felt. In 5 receptions, Worthy went off for 83 receiving yards and 38 rushing yards. While he did not score a TD, Worthy’s presence certainly elevated the Chiefs’ passing game, gaining essential yardage on third downs. The Jaguars rank 24th in passing defense and Worthy should be able to cross 58.5 receiving yards with ease.
Patrick Mahomes this season is already over 100 rushing yards. The Chiefs are outside the top-10 passing offense this season, and rank 19th in rushing offense. While Mahomes typically is a pass first QB, he has taken matter in his own hands if all of his players are covered. Looking at the Chiefs’ wobbly offense, Mahomes may decide to run with the football more often in this game, crossing 21.5 rushing yards.
The Kansas City Chiefs (2-2) visit the Jacksonville Jaguars (3-1) at EverBank Stadium for Monday Night Football, kicking off at 8:15 p.m. ET. The Chiefs, fresh off a dominant win over Baltimore, rely on Patrick Mahomes’ precision passing, while the Jaguars boast a league-leading 13 takeaways and a top rushing attack led by Travis Etienne Jr. While injuries linger for the Jaguars, this will be a great clash between the two AFC teams.
We expect the Kansas City Chiefs to win the contest, even though the Jaguars have been very impressive, especially on the defensive side of the field. The Chiefs attack led by Patrick Mahomes, despite their struggles earlier on, are starting to slowly but steadily come back. With Xavier Worthy back in the lineup, the Chiefs looked incredible against the Baltimore Ravens last week. Expect a close Chiefs victory in this one.
Prediction: Chiefs win the game 24-21
Here are some of the best player bets and over/under for the Jacksonville Jaguars and the Kansas City Chiefs, as per BetMGM
Given below are over/under for the Jacksonville Jaguars, as per BetMGM
| Over/Under Bets | Over | Under |
|---|---|---|
| Trevor Lawrence passing yards | 219.5 (-115) | 219.5 (-115) |
| Brian Thomas Jr. receiving yards | 56.5 (-115) | 56.5 (-115) |
| Travis Etienne Jr. rushing yards | 60.5 (-118) | 60.5 (-110) |
Here are some of the best player bets for the Jacksonville Jaguars, as per BetMGM
Listed below are over/under odds for the Kansas City Chiefs, according to BetMGM
| Over/Under Bets | Over | Under |
|---|---|---|
| Patrick Mahomes passing yards | 254.5 (-115) | 254.5 (-115) |
| Xavier Worthy receiving yards | 58.5 (-110) | 58.5 (-118) |
| Isiah Pacheco rushing yards | 29.5 (-110) | 29.5 (-120) |
Here are some of the best player bets for the Kansas City Chiefs, as per BetMGM
Looking at the spread and the moneyline, the Chiefs are the slight favorites to win the matchup against the Jaguars, according to BetMGM
| Teams | Spread | Total Points | Moneyline |
|---|---|---|---|
| Chiefs | -3.5 (-105) | 45.5 (-110) | -185 |
| Jaguars | +3.5 (-115) | 45.5 (-110) | +150 |
(According to BetMGM: BetMGM offers exclusive promo codes, bonus deals and accurate odds for users upon signing up. Use BetMGM to ace your betting game in all sports!)
Who is favored to win between the Jaguars and the Chiefs?
The Chiefs are the slight 3.5-point favorites to win the matchup against the Jaguars.
What is the over/under total for the game?
The over/under for total points is set at 45.5.
What is the predicted score for the Jaguars vs Chiefs game?
We expect the Chiefs to take home the victory with a close victory over the Jaguars, with the finals score being 24-21.
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