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Holger Rune vs. Francisco Comesana Head to Head Record, Preview and Prediction for ATP Italian Open 2025 Round-2

Sankalp Harikrishnan

Rune won the Barcelona Open 2025 title.

Fresh off his Barcelona Open Banc Sabadell title charge, Holger Rune is set to entertain fans at the 2025 Italian Open in Rome. The Danish prodigy begins his campaign with a tricky encounter against Francisco Comesana of Argentina. The 24-year-old beat Daniel Altmaier 6-1 7-5 in Round-1. On the other hand, Rune was forced to retire from the Madrid Masters due to a right quad injury – making his Foro Italico return a crucial pit stop before Roland Garros.

Holger Rune has captured a solitary title in 2025 – the Barcelona Open. The 22-year-old Dane outplayed World No. 3 Carlos Alcaraz in the final. Rune was also the runner-up at Indian Wells this year, falling short vs newly crowned World No. 5 Jack Draper in the summit clash. He has a 15-8 record this year. Rune was the finalist at the Internazionali d’Italia in 2023, but lost in Round-3 to Sebastian Baez last year.

READ ALSO: 2025 Italian Open Hit With Withdrawal Bombshells as Two Former World No. 2s Pull Out

The Italian Open could promise to be a happy hunting ground for Francisco Comesana. The World No. 63 made the Spanish crowd stand up and take notice when he overpowered Pedro Martinez and Arthur Fils en route to a Round of 32 showing in Madrid. Comesana reached the final at the Oeiras Open 4, and made the semifinal in Rio this year.

Holger Rune vs Francisco Comesana Head to Head Record

Holger Rune and Francisco Comesana share a 0-0 head to head record so far. The Italian Open Round of 64 clash will be the first time these two stars take to court against each other.

Holger Rune vs Francisco Comesana Title Comparison

Holger RuneCategoryFrancisco Comesana
0Grand Slams0
5ATP Singles Titles0
0ATP Doubles Titles0
1Masters-1000 Titles0
1ATP-500 Titles0
Olympics Best Performance
No. 10Current World RankingNo. 63

Holger Rune vs Francisco Comesana Italian Open 2025 Prediction

Under the warm conditions in Rome, this match-up will be a test of endurance for both players. We saw Rune using the backhand to forehand drop shot tactic brilliantly against Karen Khachanov in Barcelona. The No. 9 seed will look to dictate play from the back of the court. Provided he is to pull off an epic upset, Comesana must attack the Rune serve and stretch those quad muscles.

Prediction: Holger Rune in straight sets.

READ MORE: ‘Fallen’ Casper Ruud Saluted By Former World No. 1 for Return to Form Amid Mental Health Concerns

Holger Rune vs Francisco Comesana Italian Open 2025 Betting Odds

Holger Rune Win: 2/7

Francisco Comesana Win: 3/1

A passionate sports fan through and through, I am currently pursuing my MA in Global Sports Journalism. I specialise in tennis and football writing at The PlayOffs, and I have prior experience working at EssentiallySports and Sportskeeda. Born and raised in Bengaluru, India, sport was my safe space right from my childhood. After trying my hand at multiple sports and representing my educational institutions in cricket, badminton and table tennis, I found sports media to be my calling.

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