Mandatory Credit: Brett Davis-Imagn Images

Week 12 Monday Night Football – Where to Watch 49ers vs Panthers Game Tonight?

Mandatory Credit: Brett Davis-Imagn Images

The Carolina Panthers make the long journey to the West Coast as they go up against the San Francisco 49ers in tonight’s Week 12 Monday Night Football (MNF). Tonight’s game will mark the end of yet another week of football games as we start to inch closer to the conclusion of the 2025-26 NFL regular season.

The San Francisco 49ers are coming into tonight’s game with an impressive 7-4 record despite their multiple injury issues over the course of the season. The Panthers, on the other hand, are 6-5, needing a win to take control of the AFC South with the Buccaneers losing last night.

What Time Do The 49ers Play the Panthers on Monday Night Football Tonight?

The San Francisco 49ers are set to take on the Carolina Panthers in Week 12 of Monday Night Football at 8:15 p.m. ET. The game will be played at Levi’s Stadium in Santa Clara, California.

Grind don’t stop 😤 pic.twitter.com/OjmwHjnuY4
— San Francisco 49ers (@49ers) November 21, 2025

Where to Watch the 49ers vs Panthers Tonight?

The broadcasting rights for all Monday Night Football games belong to ESPN. Therefore, tonight’s game between the 49ers and the Panthers will be telecast on ESPN. Locals residing in the Bay Area can also watch the game on ESPN’s sister channel, ABC.

Streaming options for the 49ers vs Panthers game include the Watch ESPN app as well as other services such as YouTube TV, Fubo, Hulu+, and NFL+ for mobiles or tablets.

49ers vs Panthers Head-to-Head Record Ahead of MNF

The San Francisco 49ers and the Carolina Panthers have played a total of 23 times, with the Panthers holding a 13-10 lead in their head-to-head record. The two teams met for the first time on November 5, 1995, in a low-scoring game that finished 13-7 in favor of the Panthers.

Since the two teams belong to different divisions, they generally do not play each other for multiple seasons in between. Thus, the last meeting between the two teams came in October 2022 when the 49ers blew out the Panthers 37-15.

🏈 Panthers fans! Ticketmaster is giving away FREE Terrace tickets to home games this season!

Enter ➡️ https://t.co/NDreoVweh6 @Ticketmaster | #KeepPounding pic.twitter.com/QmWetOsCVP
— Carolina Panthers (@Panthers) November 22, 2025

Week 12 Monday Night Football Result Prediction

The 2025-26 season has been quite a turnaround for the Panthers. Although there is still plenty to improve upon, this season has seen a marked improvement in the quarterback play and the overall offense. That said, the 49ers will be a tough opponent to take down on the road.

San Francisco has dealt with a plethora of injury problems to key players on both sides of the ball. They also lost several quality players in the offseason, and yet they are still in contention for the postseason. The 49ers are a strong unit led by a smart coaching staff.

Week 12 MNF Kick-Off Time: 8:15 PM ET
Location: Levi’s Stadium, Santa Clara, California

Our Prediction: San Francisco 49ers to win.

Mandatory Credit: Brett Davis-Imagn Images

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Devavrat Kulkarni

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I am a content writer for the NFL team, and joined The Playoffs after working with Sportskeeda and NFL Analysis as an NFL writer. After starting my professional career as a French-to-English translator, working as a content writer is a new adventure for me. I started out in the sports media field for two main reasons: my love for sports in general, especially the NFL, NBA, and Tennis, as well as my passion for writing. The best part of this job is that I get to write a variety of pieces with the freedom to explore content from various angles. It also enables me to stay up to date with the sporting world, which otherwise can be difficult to do in the day-to-day grind. In a world full of chaos, sports unite and entertain like nothing else!