49ers vs Panthers Predictions, Odds and Best Bets For Week 12 of the 2025-26 NFL Season

The 49ers take on the Panthers in a big game for both teams looking to compete for a place in the playoffs

49ers vs Panthers Predictions, Odds and Best Bets For Week 12 of the 2025-26 NFL Season

Week 12’s Monday Night Football (MNF) will see the Carolina Panthers travel to the West Coast to take on the San Francisco 49ers. Both teams will be desperate for a win, as their chances of progressing to the postseason could take a massive hit following a loss. The 49ers are 7-4, whereas the Panthers come into the game with a 6-5 record.

Game Details:

Time: 8:15 p.m. ET
Date: Monday, November 24, 2025
Location: Levi’s Stadium, Santa Clara, California
TV Channel: ESPN
Streaming: Fubo, Hulu+ Live TV, NFL+, YouTube TV

Recommended bets and updated odds

Recommended Bets	FanDuel	BetMGM
Brock Purdy Over 1.5 Passing Touchdowns	-174	-167
Cristian McCaffrey Anytime TD Scorer	-380	-385
Tota Score Under 49.5	-115	-117

Analysis and Rationale

Brock Purdy has only played three games this season after missing plenty of time due to injury. Nevertheless, whenever he has played, he has looked sharp, especially in the endzone. He has thrown for 2 touchdowns or more in all three games and has a total of 7 passing touchdowns.

The majority of the offensive workload had fallen on the shoulders of Christian McCaffrey with injuries to key pass catchers on offense. McCaffrey has done a splendid job carrying the offense, and he is a top prospect to score a touchdown either on the ground or in the air. McCaffrey currently has 11 touchdowns in 11 games this season.

The total score under 49.5 seems to be a good bet as both defenses are allowing roughly 23 points per game. Having said that, the Panthers haven’t been as consistent on offense and are averaging just under 19 points per game, while the 49ers are scoring under 24.

He's elite 🌟 pic.twitter.com/crklN6A1me
— San Francisco 49ers (@49ers) November 21, 2025

49ers vs Panthers Prediction

It is quite a wonder how the 49ers are 7-4 this year despite the plethora of injury problems the team has faced since the start of the season. That is a testament to the excellent coaching staff in San Francisco as well as the players who have performed admirably.

The Panthers, on the other hand, are in a situation they have not been in for the past few years. At 6-5, they aren’t in the playoffs just yet, but they have a chance to finish this season on a high, and just maybe they find themselves in the playoffs.

Prediction: San Francisco 49ers to win.

Week 12 49ers vs Panthers Betting Odds and Spread

The moneyline and spread show the San Francisco 49ers are the favorites in this matchup against the Carolina Panthers. (Sourced from FanDuel).

	Moneyline	Spread	Total Points
San Francisco 49ers	-370	-7 (-110)	O 49.5 (-105)
Carolina Panthers	+295	+7 (-110)	U 49.5 (-115)

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49ers vs Panthers Best Bets

Here are the over/under and best player bets for the San Francisco 49ers and the Carolina Panthers, as per FanDuel.

San Francisco 49ers Over/Under Odds

Below are some of the best over/under bets for the San Francisco 49ers.

Over/ Under Bets	Over	Under
Brock Purdy Pass Attempts	32.5 (-108)	32.5 (-120)
George Kittle Total Receptions	4.5 (-138)	4.5 (+104)
Christian McCaffrey Rush Attempts	17.5 (-118)	17.5 (-112)

San Francisco 49ers Best Player Bets

Below are some of the best player bets for the San Francisco 49ers.

Brock Purdy 225+ Passing Yards: -225
Christian McCaffrey Over 119.5 Total scrimmage yards: -114
Jauan Jennings 50+ Receiving Yards: +116

If you’re looking for a complete guide to the best NFL betting sites, we’ve got you covered

A little something special for primetime pic.twitter.com/CMV5K6lrfY
— Carolina Panthers (@Panthers) November 20, 2025

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Carolina Panthers Over/Under Odds

Below are some of the best over/under bets for the Carolina Panthers.

Over/ Under Bets	Over	Under
Bryce Young Pass Attempts	33.5 (-114)	33.5 (-114)
Tetairoa McMillan Total Receptions	4.5 (-172)	4.5 (+128)
Rico Dowdle Rush Attempts	18.5 (+102)	18.5 (-136)

Carolina Panthers Best Player Bets

Below are some of the best player bets for the Carolina Panthers.

Bryce Young 200+ Passing Yards: -130
Rico Dowdle 60+ Rushing Yards: -245
Tetairoa McMillan 50+ Receiving Yards: -240

The above odds are sourced from FanDuel. Use FanDuel to ace your betting game in all sports!

FAQs

What is the over/under for total points for the 49ers vs Panthers game?

The over/under for total points in the 49ers vs Panthers game is set at 49.5.

What is the point spread for the 49ers vs Panthers game?

The 49ers come into the game as 7-point favorites over the Panthers.

What is the moneyline for the 49ers vs Panthers game?

The 49ers are the favorites with a moneyline of -370, while the Panthers are the underdogs at +295.

Mandatory Credit: Imagn Images

Devavrat Kulkarni

nfl

I am a content writer for the NFL team, and joined The Playoffs after working with Sportskeeda and NFL Analysis as an NFL writer. After starting my professional career as a French-to-English translator, working as a content writer is a new adventure for me. I started out in the sports media field for two main reasons: my love for sports in general, especially the NFL, NBA, and Tennis, as well as my passion for writing. The best part of this job is that I get to write a variety of pieces with the freedom to explore content from various angles. It also enables me to stay up to date with the sporting world, which otherwise can be difficult to do in the day-to-day grind. In a world full of chaos, sports unite and entertain like nothing else!