Picks
Sportsbooks
Casino
Promos
Prediction Markets
Lottery
Guide
NFL NFL
Picks Sportsbooks Casino Promos Prediction Markets Lottery Guide
Gambling is prohibited for underage individuals | Commercial content | Regional restrictions may apply | T&Cs apply | Play responsibly

NFL Week 12 Picks, Spreads, and Predictions – Lines, Spreads, and Betting Odds for Every Team ahead of 2025-26 Season Week 12

Devavrat Kulkarni

The Ravens and Seahawks come into their week 12 games as massive favorites!

After yet another eventful week in the NFL came to an end with the Dallas Cowboys crushing the Las Vegas Raiders on Monday Night Football’s (MNF) prime time slot, it is now time to turn our attention to Week 12 of the season.  

Once again, there will be some key matchups along the 14-game slate spread over three days, including Thursday Night Football (TNF), the Sunday games, and the MNF game for the week, featuring the San Francisco 49ers and the Carolina Panthers. 

NFL Week 12 Team Picks

Here are some of the best picks ahead of the full slate of Week 12 games as per the odds on FanDuel.

  • New England Patriots win and cover the spread (-7.5) against the Cincinnati Bengals: -118
  • Chicago Bears win and cover the spread (-2.5) against the Pittsburgh Steelers: -120
  • Jacksonville Jaguars win over Arizona Cardinals: -146
  • Philadelphia Eagles win and cover the spread (-3.4) against the Dallas Cowboys: -102

NFL Week 12 Spreads

Looking at the spreads for week 12, both the Baltimore Ravens and the Seattle Seahawks are massive favorites in their respective games. The Ravens have a 13.5-point advantage over the New York Jets, while the Seahawks hold the same advantage over the Tennessee Titans. The Detroit Lions are also huge favorites over the New York Giants with a spread of -10.5. 

On the other hand, the Falcons vs Saints game is nearly a coin flip, with a spread differential of just 1.5 points, favoring the Saints.

Moneylines and Betting Odds for Week 12

Once again, the Ravens and the Seahawks are massive favorites over the Jets and the Titans, respectively, with both teams holding moneyline odds of -1150. The Lions are the next best team with a -600 moneyline over the Giants. 

Let us now take a look at the betting odds as per FanDuel for all week 8 matchups, along with the predictions.

Buffalo Bills (7-3) vs Houston Texans (5-5)

Josh Allen is coming off one of the best games of his career with a 6-touchdown performance over the Buccaneers. The Bills are strolling along quite well with a 7-3 record and are the favorites in this game. The Texans started the season slowly, but have managed to come up to .500. Key injuries have hurt their campaign this season.   

MoneylineSpreadTotal Points
Buffalo Bills-275-5.5 (-122)O 43.5 (-110)
Houston Texans+225+5.5 (+100)U 43.5 (-110)

Prediction: Buffalo Bills to win.

Indianapolis Colts (8-2) vs Kansas City Chiefs (5-5)

The Colts are coming off a bye week and are one of the best teams in the league this season. Jonathan Taylor is having a career year, while Daniel Jones is a completely different player from his Giants days. The Chiefs, on the other hand, have lost 2 straight and now find themselves in a near must-win situation.

MoneylineSpreadTotal Points
Indianapolis Colts+152+3.5 (-120)O 49.5 (-115)
Kansas City Chiefs-180-3.5 (-102)U 49.5 (-105)

Prediction: Indianapolis Colts to win.

New England Patriots (9-2) vs Cincinnati Bengals (3-7)

What a turnaround the Patriots are having in Mike Vrabel’s first year in charge of the team. Drake Maye is in the running for the MVP in just his second season. It’s a completely different story in Cincinnati, with the Bengals just very close to missing out on a playoff berth.

MoneylineSpreadTotal Points
New England Patriots-420-7.5 (-118)O 49.5 (-110)
Cincinnati Bengals+330+7.5 (-104)U 49.5 (-110)

Prediction: New England Patriots to win and cover the spread.

Pittsburgh Steelers (6-4) vs Chicago Bears (7-3)

Pittsburgh is having a so-so season with 6 wins and 4 losses. At times, they have played well, while in other games they have looked flat. The Bears started shaky but have tallied multiple wins lately and are currently in good form. 

MoneylineSpreadTotal Points
Pittsburgh Steelers+124+2.5 (-102)O 44.5 (-120)
Chicago Bears-146-2.5 (-120)U 44.5 (-102)

Prediction: Chicago Bears to win and cover the spread.

FanDuel
Star full
Star full
Star full
Star full
Star full
check
High total bonus ceiling
check
Daily second-chance bet protection
check
No promo code required
Click to reveal code
COPIED
F A N D U V I P
Claim now arrow
New customers only. Must be 21+ in most jurisdictions, but 18+ in DC, KY, and WY. Offer is valid only in eligible regulated states/jurisdictions and not available in AR; void where prohibited. First online real-money wager only; cashed-out or bonus-funded bets are excluded.

New York Jets (2-8) vs Baltimore Ravens (5-5)

After starting the season 1-4, the Ravens are suddenly closing in on the Steelers in the AFC North by winning 4 of the last 5 games. As for the Jets, their season is over, and they are playing only for pride.

MoneylineSpreadTotal Points
New York Jets+730+13.5 (-110)O 44.5 (-110)
Baltimore Ravens-1150-13.5 (-110)U 44.5 (-110)

Prediction: Baltimore Ravens to win.

Seattle Seahawks (7-3) vs Tennessee Titans (1-9)

The Titans have the worst record in the league and are the worst team in multiple areas. Going up against the Seahawks, this is a David vs Goliath type of game. There is absolutely no reason for Seattle not to win this game and improve to 8-3 on the year. 

MoneylineSpreadTotal Points
Seattle Seahawks-1150-13.5 (-108)O 40.5 (-114)
Tennessee Titans+730+13.5 (-112)U 40.5 (-106)

Prediction: Seattle Seahawks to win.

New York Giants (2-9) vs Detroit Lions (6-4)

This is a big game for the Lions. While they are easily the favorites over the Giants, any slip-up here will have them struggling to make up ground in the race to the postseason. New York’s season has been horrendous, with key players getting injured as well as the sacking of former head coach Brian Daboll. 

MoneylineSpreadTotal Points
New York Giants+450+6.5 (-108)O 49.5 (-115)
Detroit Lions-600-6.5 (-112)U 49.5 (-105)

Prediction: Detroit Lions to win.

If you’re looking for a complete guide to the best NFL betting sites, we’ve got you covered 

Minnesota Vikings (4-6) vs Green Bay Packers (6-3-1)

This divisional matchup is important for both teams since the NFC North is a tight division. A win for the Packers will help them keep pace with the Bears at the top, while a win for the Vikings will only make things even more interesting. 

MoneylineSpreadTotal Points
Minnesota Vikings+250+6.5 (-108)O 41.5 (-105)
Green Bay Packers-310-6.5 (-112)U 41.5 (-115)

Prediction: Green Bay Packers to win.

Cleveland Browns (2-8) vs Las Vegas Raiders (2-8)

A game at this stage of the season does not matter much. Both the Browns and Raiders are as good as out of the playoffs. But Cleveland has a top defense, which should provide a tough test for Geno Smith and the Raiders’ offense.  

MoneylineSpreadTotal Points
Cleveland Browns+152+3.5 (-120)O 36.5 (-104)
Las Vegas Raiders-180-3.5 (-102)U 36.5 (-118)

Prediction: Cleveland Browns to win.

FanDuel
Star full
Star full
Star full
Star full
Star full
check
High total bonus ceiling
check
Daily second-chance bet protection
check
No promo code required
Click to reveal code
COPIED
F A N D U V I P
Claim now arrow
New customers only. Must be 21+ in most jurisdictions, but 18+ in DC, KY, and WY. Offer is valid only in eligible regulated states/jurisdictions and not available in AR; void where prohibited. First online real-money wager only; cashed-out or bonus-funded bets are excluded.

Jacksonville Jaguars (6-4) vs Arizona Cardinals (3-7)

A crucial game for the Jaguars, as a win here will only help their case to push for a playoff spot. Jacksonville, at times, has looked very tough to beat, but at other times, they have not matched those expectations. As for the Cardinals, it’s another year of disappointments.

MoneylineSpreadTotal Points
Jacksonville Jaguars-146-2.5 (-112)O 47.5 (-105)
Arizona Cardinals+124+2.5 (-108)U 47.5 (-115)

Prediction: Jacksonville Jaguars to win.

Atlanta Falcons (3-7) vs New Orleans Saints (2-8)

The Falcons could have challenged the Buccaneers in the NFC South this season, but that has not been the case. Now, the latest development from Atlanta is that starting quarterback Michael Penix Jr. will miss the remainder of the season. The Saints are coming off their bye week and while also winning their Week 10 game against the Panthers. 

MoneylineSpreadTotal Points
Atlanta Falcons+108+1.5 (-110)O 39.5 (-105)
New Orleans Saints-126-1.5 (-110)U 39.5 (-115)

Prediction: New Orleans Saints to win.

Philadelphia Eagles (8-2) vs Dallas Cowboys (4-5-1)

This is one of the most critical games of the season for the Dallas Cowboys. With a 4-5-1 record, they need to stack wins. The Cowboys looked good last week, but that was against the Raiders. Philly will pose a much tougher challenge. As for the Eagles, they have had their struggles on offense, but they keep managing to win games. 

MoneylineSpreadTotal Points
Philadelphia Eagles-174-3.5 (-102)O 47.5 (-115)
Dallas Cowboys+146+3.5 (-120)U 47.5 (-105)

Prediction: Philadelphia Eagles to win and cover the spread.

Tampa Bay Buccaneers (6-4) vs Los Angeles Rams (8-2)

Tampa Bay started the season red hot, but the injury to Mike Evans was a huge blow. The Bucs are currently on a two-game losing streak, and they are up against an in-form Rams team that has won its last 5 games. Matthew Stafford is playing at a high level despite his age and back issues in the offseason. 

MoneylineSpreadTotal Points
Tampa Bay Buccaneers+265+6.5 (-102)O 49.5 (-110)
Los Angeles Rams-330-6.5 (-120)U 49.5 (-110)

Prediction: Los Angeles Rams to win.

FanDuel
Star full
Star full
Star full
Star full
Star full
check
High total bonus ceiling
check
Daily second-chance bet protection
check
No promo code required
Click to reveal code
COPIED
F A N D U V I P
Claim now arrow
New customers only. Must be 21+ in most jurisdictions, but 18+ in DC, KY, and WY. Offer is valid only in eligible regulated states/jurisdictions and not available in AR; void where prohibited. First online real-money wager only; cashed-out or bonus-funded bets are excluded.

Carolina Panthers (6-5) vs San Francisco 49ers (7-4)

The Panthers have done well to get to 6-5 at this stage of the season. Wins over the Cowboys and the Packers are the highlights of their season so far, but they are up against a resilient 49ers team that has been winning games despite several key starters missing games or having suffered season-ending injuries. 

MoneylineSpreadTotal Points
Carolina Panthers+275+7 (-110)O 48.5 (-105)
San Francisco 49ers-340-7 (-110)U 48.5 (-115)

Prediction: San Francisco 49ers to win.

All of the above odds are sourced from FanDuel. Use FanDuel to ace your betting game in all sports!

Mandatory Credit: Gary A. Vasquez-Imagn Images

nfl nfl

I am a content writer for the NFL team, and joined The Playoffs after working with Sportskeeda and NFL Analysis as an NFL writer. After starting my professional career as a French-to-English translator, working as a content writer is a new adventure for me. I started out in the sports media field for two main reasons: my love for sports in general, especially the NFL, NBA, and Tennis, as well as my passion for writing. The best part of this job is that I get to write a variety of pieces with the freedom to explore content from various angles. It also enables me to stay up to date with the sporting world, which otherwise can be difficult to do in the day-to-day grind. In a world full of chaos, sports unite and entertain like nothing else!

Read more