Buffalo Bills vs New England Patriots Preview, Predictions, and Betting Odds – Week 5 SNF 2025-26 NFL Season

The Buffalo Bills are set to take on the New England Patriots for their Week 5 Sunday Night Football action on NBC. The Bills are off to a blazing start towards their 2025 season, winning all of their matchups so far and going 4-0, thanks to their amazing offensive unit. Meanwhile, the New England Patriots are .500, going 2-2 for their season so far, winning their last matchup against the Carolina Panthers.

❄️ WHITE OUT ALERT ❄️#BillsMafia | More info: https://t.co/YBgz7FXIc9 pic.twitter.com/jH3btn3DAT
— Buffalo Bills (@BuffaloBills) September 30, 2025

Recommended Bets	FanDuel	BetMGM
James Cook anytime TD scorer	-230	-210
Josh Allen anyime TD scorer	-125	-120
Drake Maye Over 0.5 INTs thrown	-114	-118

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Rationale and Analysis

James Cook is one of Bills most dangerous weapons. He had already put up 401 rushing yards for the season, with 75 rushing attempts. The Bills have utilized him a lot in their offense, and the best part, it’s working. To go along with his yardage for the season, Cook also has 5 TDs this season, scoring in every game so far. While the Pats are great in rushing defense (2nd), they rank 10th in scoring defense, leaving room for Cook to score.

Josh Allen has already accounted for 7 touchdowns this season, and has scored in every game except one. He’s coming off a 2 TD performance against the Saints and the reigning MVP has been the locomotive for the Bills’ offense. Whether it’s rushing with the ball or passing, Allen is a threat to score every game.

Drake Maye over 0.5 INTs is a great bet, as the Bills are No.1 in passing defense this season. While Maye has had a great start to the season and thrown only one interception, looking at the Bills’ passing defense, we believe that Maye could thrown an interception for the game.

Bills vs Patriots Preview

The Buffalo Bills are set to face the New England Patriots at Highmark Stadium, for Week 5 Sunday Night Football action. The Bills are 4-0 to start their season, and their offense is functioning through the roof, ranking 2nd in the league in total offense, scoring 16 TDs for the season. Josh Allen, James Cook, Khalil Shakir, and the rest of the group have looked unstoppable so far, but their winning streak also comes having an easier schedule than the rest.

Meanwhile, Drake Maye and the Pats are 2-2 to start their season, and they have shown a lot of improvements this season. Surprisingly, their WR Stefon Diggs has not scored a TD this season and is still adjusting to head coach Mike Vrabel’s system. While the Pats still have a long way to go, they are coming off a dominant win over the dominant win over the Panthers in Week 4, trying to build further momentum in this AFC East showdown.

The Nor’easter is here.

Introducing the Patriots 𝙉𝙁𝙇 𝙉𝙞𝙠𝙚 𝙍𝙞𝙫𝙖𝙡𝙧𝙞𝙚𝙨 uniform. pic.twitter.com/gQw1P1px3I
— New England Patriots (@Patriots) August 28, 2025

Bills vs Patriots Prediction

While the Patriots have shown improvement along with QB Drake Maye’s growth, they are still far from perfect, dropping games against the Steelers and the Raiders in Weeks 3 and 1. Looking at this we believe that the Bills will take home the victory as their offense talent is just too overwhelming for most teams to overcome.

Prediction: Bills win the game 31-21

Bills vs Patriots Betting Odds

Here are over/under and best player bets for the Buffalo Bills and the New England Patriots according to BetMGM

Buffalo Bills Over/Under Odds

Below listed are over/under odds for the Buffalo Bills, as per BetMGM

Over/Under Odds	Over	Under
Josh Allen passing yards	233.5 (-118)	233.5 (-115)
Khalil Shakir receiving yards	42.5 (-110)	42.5 (-118)
James Cook rushing yards	78.5 (-115)	78.5 (-115)

Buffalo Bills Best Player Bets

Here are some of the best player bets for the Buffalo Bills, according to BetMGM

James Cook anytime TD scorer: -210
Josh Allen anytime TD scorer: -140
Josh Allen under 0.5 INTs thrown: -150

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New England Patriots Over/Under Odds

Listed below are over/under odds for the New England Patriots, according to BetMGM

Over/Under Bets	Over	Under
Drake Maye passing yards	223.5 (-115)	223.5 (-115)
Stefon Diggs receiving yards	47.5 (-115)	47.5 (-118)
Rhamondre Stevenson rushing yards	30.5 (-110)	30.5 (-118)

New England Patriots Best Player Bets

Here are some of the best player bets for the New England Patriots, according to BetMGM

Drake Maye over 0.5 INTs thrown: -118
Drake Maye under 1.5 passing TDs: -145
Stefon Diggs under 4.5 receptions made: -135

Bills vs Patriots Spread and Betting Odds

Looking at the spread and the moneyline, the Bills are the huge favorites to take down the New England Patriots, as per BetMGM

Teams	Spread	Total Points	Moneyline
Patriots	+8 (-110)	49.5 (-110)	+350
Bills	-8 (-110)	49.5 (-110)	-450

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(According to BetMGM: BetMGM offers exclusive promo codes, bonus deals and accurate odds for users upon signing up. Use BetMGM to ace your betting game in all sports!)

FAQs

Who is favored to win between the Bills and the Patriots?
The Bills are the huge 8-point favorites to win the matchup against the Patriots.

What is the over/under total for the game?
The over/under for total points is set at 49.5.

What is the predicted score for the Bills vs Patriots game?
We predict the score to be 31-21 in favor of the Bills.

Eric Divakaran

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I cover the National Football League and things cannot get better than that. I always dreamed to play football or basketball professionally since I’m built like a Running Back. But now that I can’t, since I’m technically in the “Unc” age, I thought why not pick a career in sports industry? So here I am, doing what I love, and hoping that the Commanders win the Super Bowl. I give love to players when it’s due, but can be critical about their performances at the same time. Enough about me, now let my articles do all the talking.