NFL Week 4 Los Angeles Chargers vs New York Giants Preview, Betting Odds, and Predictions – 2025-26 Season

Rookie quarterback Jaxson Dart set to make his debut as a starter for the Giants in week 4 against the Chargers!

Los Angeles Chargers vs New York Giants Preview, Betting Odds, and Predictions for the 2025-26 NFL Season Week 4

The Los Angeles Chargers are on the road for this early afternoon game against the New York Giants at MetLife Stadium in East Rutherford, New Jersey. This week 4 clash pits two teams heading in the opposite direction as the 3-0 Chargers take on the 0-3 Giants.

Recommended bets and updated odds

Recommended Bets	FanDuel	BetMGM
Justin Herbert 250+ passing yards	-140	-129
Quentin Johnston 50+ receiving yards	-128	-127
Chargers to win	-295	-295

Analysis and Rationale

Justin Herbert has 860 passing yards in three games so far and is averaging a little over 285 yards per game. The improved offensive line for the Chargers is working wonders even in the passing game. Additionally, the Giants have given up a ton of yards in the air on defense.

Quentin Johnstone has been a big revelation at the start of this season. Johnstone has been the main deep threat for the Chargers’ passing game and already has 239 receiving yards and 3 touchdowns in three games. That means he is averaging nearly 80 receiving yards per game, making this bet worth considering.

The Chargers are heading into this match a perfect 3-0 through 3 weeks of football. The Giants, on the other hand, are 0-3, and it will also be the debut of rookie Jaxson Dart under center. There is a good possibility that he may struggle in his first game against one of the better defenses in the league.

The stage is set. pic.twitter.com/M1G8QDt4X0
— New York Giants (@Giants) September 22, 2025

Los Angeles Chargers vs New York Giants Preview

The Los Angeles Chargers are currently the team to beat in the AFC West. They have defeated all three of their divisional opponents within the first three weeks and are looking quite comfortable at the top. Quarterback Justin Herbert and his offensive line are on top of their game.

The Giants are dealing with plenty of problems. They are still winless through three games and have now made the change under center. Rookie Jaxson Dart is set to make his debut as the starter and will be going up against a confident Chargers’ defensive unit.

Los Angeles Chargers Best Bets – Over/Under and Player Bets

Below are some of the best player bets for the Los Angeles Chargers as sourced from FanDuel.

Los Angeles Chargers Over/Under Bets

Over/ Under Bets	Over	Under
Justin Herbert Passing Yards	257.5 (-114)	257.5 (-114)
Omarion Hampton Rushing Attempts	17.5 (+106)	17.5 (-140)
Keenan Allen Receiving Yards	47.5 (-114)	47.5 (-114)

Los Angeles Chargers Best Player Bets

Below are some of the best player bets for the Los Angeles Chargers as sourced from FanDuel.

Justin Herbert 2+ Passing Touchdowns: -146
Omarion Hampton 50+ Rushing Yards: –275
Ladd McConkey 50+ Receiving Yards: -240

this on repeat. literally. pic.twitter.com/wAK1Zz8SO1
— Los Angeles Chargers (@chargers) September 23, 2025

New York Giants Best Bets – Over/Under and Player Bets

Here is a look at the over/under and player bets for the New York Giants as per FanDuel.

New York Giants Over/Under Bets

Over/ Under Bets	Over	Under
Jaxson Dart Passing Yards	189.5 (-114)	189.5 (-114)
Cam Skattebo Rushing Yards	57.5 (-114)	57.5 (-114)
Wan’Dale Robinson Receiving Yards	37.5 (-114)	37.5 (-114)

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New York Giants Best Player Bets

Below are some of the best player bets for the New York Giants as sourced from FanDuel.

Jaxon Dart Interception: -160
Cam Skattebo 50+ Rushing Yards: -188
Malik Nabers 70+ Yards: +114

Coach Daboll confirms Jaxson Dart has been named the starting QB pic.twitter.com/cgR2Qs8Cvz
— New York Giants (@Giants) September 24, 2025

Week 4 Chargers vs Giants Predictions for NFL 2025-26

Justin Herbert and the Chargers offense are clicking well. A solid offensive line is allowing them time to make quality plays down the field, and third-year receiver Quentin Johnston has shown vast improvements in his game. The defense is equally strong and ranks within the top 10 in passing and rushing defense through three weeks.

The Giants have struggled on both sides of the ball. Apart from the game against divisional rivals, the Dallas Cowboys, New York hasn’t managed to put many points on the board. The defensive line up front has the ability to cause problems, but overall, the defensive unit hasn’t been too impressive.

Our Prediction: Chargers to win and cover the spread.

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Chargers vs Giants Betting Odds and Spread

The moneyline and spread show the Los Angeles Chargers are the favorites in this matchup against the New York Giants, as sourced from FanDuel.

	Moneyline	Spread	Total Points
Los Angeles Chargers	-290	-6.5 (-110)	O 43.5 (-110)
New York Giants	+240	+6.5 (-110)	U 43.5 (-110)

The above odds are sourced from FanDuel. Use FanDuel to ace your betting game in all sports!

FAQs

What is the over/under for total points for the Chargers vs Giants game?

The over/under for total points in the Chargers vs Giants game is set at 43.5.

What is the point spread for the Chargers vs Giants game on Sunday?

The Chargers come into the game as 6.5-point favorites over the Giants.

What is the moneyline for the Chargers vs Giants game in week 2?

The Chargers are the favorites with a moneyline of -290, while the Giants are the underdogs at +240.

Mandatory Credit: Jayne Kamin-Oncea-Imagn Images

Devavrat Kulkarni

nfl

I am a content writer for the NFL team, and joined The Playoffs after working with Sportskeeda and NFL Analysis as an NFL writer. After starting my professional career as a French-to-English translator, working as a content writer is a new adventure for me. I started out in the sports media field for two main reasons: my love for sports in general, especially the NFL, NBA, and Tennis, as well as my passion for writing. The best part of this job is that I get to write a variety of pieces with the freedom to explore content from various angles. It also enables me to stay up to date with the sporting world, which otherwise can be difficult to do in the day-to-day grind. In a world full of chaos, sports unite and entertain like nothing else!