The Serie A Matchday 22 slate takes place between January 23 and January 26, 2026 with 10 games in the roster. It’s arriving at a critical juncture in Italy’s title race and European qualification picture. Inter Milan will open the round at San Siro with an opportunity to extend their lead at the summit.
Whereas, Juventus will host Napoli in a fixture with direct implications for the Scudetto chase. Elsewhere, Roma welcome AC Milan in a clash between two sides balancing domestic ambition with European considerations. Injuries, fixture congestion, and tactical mismatches have shaped market prices across the board.
For more analysis across Italy and Europe, visit our main soccer predictions and Serie A betting tips hub, but for now, scroll on for today’s best bets.
Odds from FanDuel and BetMGM, accurate as of Friday morning ET. Serie A lines can move quickly on matchday, so always check the latest prices before betting.
Best Bet #1 – Inter Milan vs Piss: Lautaro Martinez to Score or Assist
Inter Milan will host Pisa on January 23, 2026 at San Siro, returning to league action after a demanding Champions League fixture. Despite European distraction, Inter’s domestic form remains elite. Across their last 10 Serie A matches, they have taken 22 points. They’re also averaging approximately 1.95 expected goals per game.
They’ve conceded under 0.90 xGA as well. Their home numbers are even stronger, with sustained pressure and territorial dominance reflected in one of the league’s highest shot volumes inside the penalty area. Lautaro Martinez continues to function as the decisive figure in Inter’s attack.
He has scored 11 league goals this season. Eight of them have come at deciding moments. Over his last 10 league appearances, Martinez has produced six goals and two assists from just over five expected goals. He averages more than three shots per 90 minutes. Martinez also remains their primary penalty-box target during sustained possession phases.
Pisa’s defensive structure has held firm away from home in terms of results, but they’ve also shown vulnerability against elite attacks. They’ve allowed over 1.45 xGA per away match and struggled defending central channels. With multiple defensive injuries limiting rotation options, Pisa are facing sustained pressure.
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Juventus will host Napoli on January 25, 2026 in one of Matchday 22’s defining fixtures. The Bianconeri enter this contest with strong home form. They’ve lost just once at the Allianz Stadium in Serie A this season. Juventus have conceded 1.07 xGA per game so far this season, supported by a compact mid-block and improved ball security in midfield.
Their recent wins have been built on control rather than volume, limiting opponents to low-quality chances. Whereas, Napoli’s away performances have been inconsistent. While still capable of spells of attacking quality, they have averaged over 1.6 xG on the road. Defensive transition remains an issue against structured opponents.
Injuries in wide areas have reduced their ability to stretch play. It has forced them to play through more central buildup where Juventus are strongest defensively. Head-to-head meetings in Turin have favored Juventus in recent seasons. Especially in matches where Napoli struggle to dictate tempo. With Juventus benefiting from greater recovery time and home-field advantage, the evens price underrates their probability.
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Roma will face AC Milan on January 26, 2026 at the Stadio Olimpico in a matchup shaped by attacking depth and defensive volatility. Roma’s recent home fixtures have consistently featured goals at both ends. Across their last 10 league matches, Roma have scored 14 goals while conceding 7.
Roma are boasting an average combined xG exceeding 1.6 per game. Their aggressive pressing underpins chance creation but also leaves space behind the back line. AC Milan’s away profile supports the BTTS angle. Milan have generated nearly 1.3 xG per match on the road.
But they have also conceded in five of their last 10 league fixtures. They’ve struggled to maintain compactness when fullbacks push high. Rafael Leao’s ball-carrying and Christian Pulisic’s off-ball movement ensure Milan remain a consistent scoring threat regardless of venue.
Recent head-to-head meetings between these sides have frequently produced goals, driven by open midfield play and transitional moments. Both teams are competing for Champions League positions and neither are incentivized to settle for a draw. Hence, the -112 price seems probable in a matchup likely to feature chances for both attacks.
Serie A Best Bets for Matchday 22 Recap – January 23-26, 2026
Best Bet #1: Inter Milan vs Pisa – Lautaro Martinez to Score or Assist (-190 at FanDuel)
Best Bet #2: Juventus vs Napoli – Juventus to Win (Evens at BetMGM)
Best Bet #3: Roma vs AC Milan – Both Teams to Score: Yes (-112 at FanDuel)
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