Inter Milan will host Pisa at San Siro on Friday, January 23, 2026, as Serie A Gameweek 22 opens with a fixture that could significantly shape the title race. The league leaders return to domestic action following a demanding Champions League defeat to Arsenal. They’ll be facing a Pisa side entrenched in the relegation battle but stubbornly competitive away from home.
Inter are entering this match with an opportunity to apply pressure on AC Milan and Napoli. Both teams will face difficult fixtures later in this round. The Nerazzurri boast one of the league’s most efficient defensive records and have dominated this fixture historically. However, Pisa’s away resilience and Inter’s tight turnaround from European duty add intrigue.
Matchday, 𝗡𝗘𝗪 𝗖𝗢𝗡𝗗𝗜𝗧𝗜𝗢𝗡𝗦 🏔️ Performance starts on the pitch ⚽️
You can find more of our soccer predictions on our main picks hub. Here’s how we’re betting Inter Milan vs Pisa tonight, including our Best Bet, a Same-Game Parlay, and key trends to know.
Inter Milan vs Pisa Match Details
Competition: Serie A
Date & kickoff: Friday, January 23, 2026 – 2:45 PM ET / 7:45 PM GT
Venue: San Siro Stadium, Milan, Italy
Expected XIs: Inter Milan 3-5-2 vs Pisa 3-4-2-1
Best Bet for Inter Milan vs Pisa
Our best bet for Inter Milan vs Pisa is Both Teams to Score: No at -190 (BetMGM) / -166 (FanDuel).
Backing Both Teams to Score: No aligns with Inter’s defensive profile and Pisa’s struggles in chance creation against elite opposition. Across Inter’s last 10 Serie A matches, they have conceded fewer than one expected goal per game on average. Their back three are consistently limiting high-quality shots in central zones.
At San Siro, Inter have allowed just two goals in their last five league home fixtures. They’ve kept clean sheets against teams operating in the bottom half. Pisa’s away record appears resilient on the surface, but underlying metrics reveal a different story. They’ve drawn in six of their last seven away matches. Even so, Pisa averaged under 1.0 xG per away game.
They also rely heavily on transition moments rather than sustained pressure. Pisa have scored multiple goals on the road. But they came largely against mid-table opponents rather than title contenders. Inter’s midfield structure, even without Hakan Calhanoglu, remains effective at controlling territory.
Whereas, Alessandro Bastoni and Benjamin Pavard rank among the league leaders in interceptions and aerial duel success. Given Inter’s ability to suppress shots and Pisa’s limited attacking depth due to injuries, a one-sided scoreline or clean-sheet win is the most probable outcome.
Inter Milan vs Pisa Prediction
Our pick: Inter Milan to Win at -450 (BetMGM) / -550 (FanDuel)
The heavily favored moneyline reflects both Inter’s dominance in this matchup and the current disparity in squad quality. Inter have won six consecutive meetings against Pisa in Serie A. It includes a controlled 2-0 away win earlier this season. Historically, Inter have not lost this fixture since 1987.
From a form perspective, Inter have won six of their last seven league matches. They’ve generated over 2.0 xG in five of those contests. Lautaro Martínez remains the attacking focal point. And Marcus Thuram’s off-ball movement and pressing have contributed to Inter ranking among Serie A’s top sides for shots created from high turnovers.
Meanwhile, Pisa are sitting 19th and have managed just one win in their last 21 league games. While their away draws show grit, they often come at the cost of attacking ambition. Inter’s depth, tactical clarity under Cristian Chivu, and motivation to capitalize on rivals’ tougher fixtures make the short odds justified. Anything other than a home win would be a major shock.
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Same-Game Parlay (Bet Builder) for Inter Milan vs Pisa
Bet $100 to Win $177.80 (FanDuel) Total Goals Over 1.5 (-650) + Both Teams to Score: No (-166) + Lautaro Martinez to either score or assist (-190)
This parlay continues to lean into Inter’s dominance at San Siro while shifting the player prop to their most reliable end-product contributor. Over 1.5 goals remains a conservative anchor. Especially given Inter’s consistent chance volume at home.
Pisa also have a tendency to concede territorial control against elite sides. Including Both Teams to Score: No reflects Inter’s defensive strength and Pisa’s limited attacking efficiency against top-four opponents. Lautaro Martinez is the focal point in Inter’s scoring output, so he should lead the line again.
The Argentine striker has delivered 11 Serie A goals this season. Eight of them have directly decided matches. His movement between the lines, pressing intensity, and sharp finishing make him Inter’s most likely player to influence the scoreboard, either through a goal or a final pass in a controlled home win.
This builder maintains strong correlation by centering on Inter’s core strengths. Matches against relegation-threatened teams at San Siro rarely remain low-scoring. Meanwhile, Pisa’s attacking limitations reduce the likelihood of both teams finding the net. Lautaro Martinez’s inclusion enhances reliability.
He remains Inter’s primary attacking reference point. His league-leading tally of match-winning goals and strong home scoring record support his probability of contributing decisively without requiring a high-scoring shootout. This combination balances risk and value effectively for bettors seeking steadier exposure.
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Over 2.5: -200 / Under 2.5: +145 Over 3.5: +120 / Under 3.5: -165
Over 2.5: -210 / Under 2.5: +168 Over 3.5: +124 / Under 3.5: -152
BTTS
Yes: +110 / No: -160
Yes: -102 / No: -124
Asian Handicap
Inter Milan -1.25: -238 / -1.50: -175 Pisa +1.25: +188
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Draw No Bet
Inter Milan: -1600 Pisa: +725
Inter Milan: -3000 Pisa: +1000
Double Chance
Inter Milan or Draw: -2000 Pisa or Draw: +310
Inter Milan or Draw: -2500 Pisa or Draw: +330
Trends to Know for Inter Milan vs Pisa
Head-to-Head: Inter have won six straight Serie A meetings and are unbeaten in this fixture since 1987.
Home Strength: Inter have conceded among the fewest home goals in the league, with elite xGA metrics at San Siro.
Pisa Away Form: Six draws in their last seven away matches highlight resilience, but underlying xG remains low.
Clean Sheets: Inter have kept multiple clean sheets in their last 10 league games, especially versus bottom-six teams.
Goal Involvement: Marcus Thuram and Lautaro Martínez account for a significant share of Inter’s goal contributions, reinforcing player-prop value.
Latest Injuries & Lineup News for Inter Milan vs Pisa
In soccer, injuries and rotations can drastically alter how a match plays out, especially when it comes to BTTS, totals, and goalscorer markets. Navigating through a few key injuries in this clash, both coaches will look to lineup their strongest XI. Here are the players who are either doubtful or are set to miss out:
Team
Player
Status
Notes
Inter Milan
Hakan Calhanoglu
Out
Calf
Inter Milan
Raffaele Di Gennaro
Out
Hand
Inter Milan
Denzel Dumfries
Out
Ankle
Inter Milan
Tomas Palacios
Out
Thigh
Pisa
Juan Cuadrado
Out
Thigh
Pisa
Raul Albiol
Out
Thigh
Pisa
Calvin Stengs
Out
Thigh
Pisa
Mateus Lusuardi
Out
Knee
Pisa
Daniel Denoon
Out
Ankle
Pisa
Isak Vural
Out
Knee
Reminder: Always check confirmed lineups 60–75 minutes before kickoff, especially for goalscorer and BTTS markets.
How to watch – quick Q&A
What time is Inter Milan vs Pisa?
Inter Milan vs Pisa kicks off at 2:45 ET on Friday, January 23, 2026 (7:45 PM local UK time).
Where is the match being played?
The match will be played at the San Siro Stadium in Milan, Italy.
How can I watch on TV / stream?
Broadcast rights vary by territory. In the US, the Serie A can be telecast on Paramount+. The match will be telecast on TNT Sports 2 and DAZN UK in the UK. The match will also be available to stream on these broadcasters’ official websites.
Football writer at The Playoffs. I’ve been obsessed with the beautiful game since I was a kid.. Eventually, I realized I could combine my passion for writing with my love for football, and I’ve never looked back. My favorite part of the job is everything—when you’re doing what you love, even a late-night deadline feels like extra time in a thrilling cup final. Lastly, Lionel Messi is the GOAT.
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