Mandatory Credit: Darren Yamashita-Imagn Images

Rams vs 49ers Injury Report – Big Questions on Purdy and Pearsall’s Injury, 2 of LA Rams Starters Sidelined

The 49ers are facing a whole bunch of injury worries ahead of the game against the Rams!

Mandatory Credit: Darren Yamashita-Imagn Images

Week 5 of the NFL season is set to kick off with the Los Angeles Rams taking on their divisional opponents, the San Francisco 49ers, on Thursday Night Football (TNF). Both teams are heading into the game with a 3-1 record, with the winner taking the lead in the NFC West at least for the time being.

The San Francisco 49ers have been battling injury problems ever since the start of the season. Multiple starters are missing games, but that hasn’t held them back from winning the first three of their four games.

In any case, let us now take a look at the latest injury report updates from both teams ahead of their week 5 clash on Thursday.

California showdown on TNF 😎

SFvsLAR– Thursday 8:15pm ET on Prime Video
Also streaming on @NFLPlus pic.twitter.com/AVpQOzLgLC
— NFL (@NFL) September 30, 2025

Los Angeles Rams Injury Report for Game versus San Francisco 49ers

As per the Rams’ latest injury report, only five players are listed, with three of them being full participants. Tight end Tyler Higbee and offensive lineman Rob Havenstein both did not practice.

Higbee is struggling with a hip injury, while Havenstein is dealing with an ankle issue. Steve Avila, Colby Parkinson, and Kamren Kinchens were all full participants in practice and should be ready for the game on Thursday.

Player	Position	Injury	Practice status	Game Status
Tyler Higbee	TE	Hip	DNP	Unspecified
Rob Havenstein	OL	Ankle	DNP	Unspecified
Steve Avila	OL	Ankle	FP	Unspecified
Colby Parkinson	TE	Shoulder	FP	Unspecified
Kamren Kinchens	S	Shoulder	FP	Unspecified

*Note: DNP – Did not practice, FP – Full participant

Those are pretty good ratings. 🤝 pic.twitter.com/WqITZh5sl5
— Los Angeles Rams (@RamsNFL) October 1, 2025

San Francisco 49ers Injury Report for Game versus Los Angeles Rams

The injury report for the 49ers lists a total of 12 players. Seven players did not practice as per the team’s latest update, while three were limited participants and only two were full participants. As per the latest reports, quarterback Brock Purdy and wide receivers Ricky Pearsall and Jauan Jennings have been ruled out for Thursday Night Football. With Purdy sidelined, Mac Jones is set to make his third start of the season under center.

Player	Position	Injury	Practice status	Game Status
Robert Beal Jr.	DL	Ankle	DNP	Unspecified
Renardo Green	CB	Neck	LP	Unspecified
Yetur Gross-Matos	DL	Knee	DNP	Unspecified
Jauan Jennings	WR	Ankle, Rib	DNP	Out
Mac Jones	QB	Knee	FP	Unspecified
Colton McKivitz	OL	Calf	FP	Unspecified
Ricky Pearsall	WR	Knee	DNP	Out
Brock Purdy	QB	Toe	DNP	Out
Jordan Watkins	WR	Calf	DNP	Unspecified
CJ West	DL	Thumb	DNP	Unspecified
Mykel Williams	DL	Wrist, Oblique	LP	Unspecified
Dee Winters	LB	Knee	LP	Unspecified

*Note: DNP – Did not practice, LP – Limited participant, FP – Full participant

Heading into this matchup, it is quite clear that the Rams are the healthier of the two teams, and that should be advantageous for Los Angeles. Having said that, this being a divisional rivalry, anything can happen as both teams know each other very well.

Mandatory Credit: Darren Yamashita-Imagn Images

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Devavrat Kulkarni

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I am a content writer for the NFL team, and joined The Playoffs after working with Sportskeeda and NFL Analysis as an NFL writer. After starting my professional career as a French-to-English translator, working as a content writer is a new adventure for me. I started out in the sports media field for two main reasons: my love for sports in general, especially the NFL, NBA, and Tennis, as well as my passion for writing. The best part of this job is that I get to write a variety of pieces with the freedom to explore content from various angles. It also enables me to stay up to date with the sporting world, which otherwise can be difficult to do in the day-to-day grind. In a world full of chaos, sports unite and entertain like nothing else!