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Philadelphia 76ers vs Cleveland Cavaliers Predictions, Picks and Odds for Friday, January 16 

Garima Ranawat
Basketball / NBA
17/01/2026 – 01:00
Philadelphia 76ers
VS
01:00
17/01/2026
Cleveland Cavaliers
Odds updated on January 16, 2026 at 6:04 am

The Philadelphia 76ers will welcome the Cleveland Cavaliers in an anticipated rematch that took place on January 14. The game saw the Cavs handing a blowout loss to the Sixers, dropping their seasonal tally to 22-17. On the other hand, the Cavs moved to a 23-19 record, in the seventh spot of the standings. 

Bookmarkers have the Philadelphia 76ers 1.5 point favorites to win the game, with moneyline at -124 and a total around 235.5 points. These NBA odds tonight clearly suggest that the Sixers would avenge their recent defeat in a tightly-fought contest. We have got our best bet, a same-game parlay and a few player props for tonight. 

Here’s how we are betting Sixers vs Cavaliers on Friday. 

Best Bets for Philadelphia 76ers vs Cleveland Cavaliers 

Best Bet: Philadelphia 76ers -1.5 (-112)

Book: Best price at FanDuel

Both the Philadelphia 76ers and the Cleveland Cavaliers have been playing good basketball this season. After having a strong start, the Sixers are now 10-10 at home, with an average scoring of 116.8, an offensive rating of 114.7, and a defensive rating of 113.4. They allow their rivals to score 115.6 points per game, while forcing 15.0 turnovers. 

On the other hand, the Cavaliers have a top-racked offensive rating of 116.9, and a defensive rating of 114.2. While the Cavs have been thriving offensively, they let their opponents score as many as 117.5 points. It suggests that they have been struggling on the defensive end, and the Sixers hold advantage here. 

The spread at -1.5 fits the Sixers well considering they have recently lost a game to the Cavs, and their better defense. 

Considering the Sixers’ overall record, an upper hand in the defense as well as familiarity with the court, we are laying the -1.5 as our Best Bet and expect the hosts to cover the number tonight. 

Same-Game Parlay for Sixers vs Cavaliers 

3-Leg SGP (Safer) 

  • Leg 1: Philadelphia 76ers -2.5 (alternate spread)
  • Leg 2: Tyrese Maxey Over 26.5 points 
  • Leg 3: Joel Embiid Over 26.5 points 

Combined odds: +587

We have built this same-game parlay around the Philadelphia 76ers to record a narrow win at home. Tyrese Maxey is the leading Sixers’ scorer, dropping over 31 points per game, leading them to crucial wins. Joel Embiid plays efficiently when healthy and is scoring around 24 points per game. 

These legs correlate considering that the Sixers will make the most of their homecourt advantage and their stars would use their familiarity with the court to score for the hosts and fill the stat-sheet with high scores. 

Philadelphia 76ers vs Cleveland Cavaliers Odds and Top Player Props 

Given below are the latest Philadelphia 76ers vs Cleveland Cavaliers odds from FanDuel. Shop around for the best NBA odds before locking in your bets. 

Team Spread Moneyline Total 
Cleveland Cavaliers +1.5 (-108)+108O 235. 5 (-110)
Philadelphia 76ers -1.5 (-112)-124U 235.5 (-110)

Odds updated on Friday, January 16, 2026 at 4:03 am ET. Lines may move throughout the day. 

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Top Player Props for Sixers vs Cavaliers 

Given how prop-heavy NBA betting is, we are also eyeing these player props for Sixers vs Cavs on Friday. 

  • Donovan Mitchell Over 30.5 points (-102)
  • Evan Mobley Over 19.5 points (-106)
  • Jarrett Allen Over 8.5 rebounds (-138)

These legs fit well into usage and volume. Mitchell is leading the Cavs in scoring, dropping an average of around 30 points. He will once again take responsibility for offense against the Sixers on Friday. Mobley is also a reliable player, who scores whenever needed. We can expect both of them to come forward and score on Friday. Jarrett Allen dominates the board in the paint, and he is expected to do the same. 

Trends to Know for Philadelphia 76ers vs Cleveland Cavaliers 

Given below are a few betting trends that one must keep in mind for Sixers vs Cavaliers. 

  • The Cavaliers are 6-12 ATS on the road this season. 
  • The Philadelphia 76ers are 6-4-0 ATS in their last ten games. 
  • Over has hit the Cavaliers in 19 of their 42 games this far. 

Latest Injuries and NBA Injury Report for Philadelphia 76ers vs Cleveland Cavaliers 

Before betting this game, it’s important to check the NBA injury report, as late scratches and minutes limits can swing spreads and totals in a hurry.

Team Player Injury Status 
Philadelphia 76ers Paul George Knee Questionable 
Philadelphia 76ers Joel Embiid Knee Probable
Cleveland Cavaliers Dean Wade Knee Out 
Cleveland Cavaliers Sam Merrill Hand Out 
Cleveland Cavaliers Darius GarlandToe Out 
Cleveland Cavaliers Chris LivinstonKnee Out 
Cleveland Cavaliers Max Strus Foot Out 

In the NBA, late injury news and minutes restrictions have a huge impact on spreads and totals, so re-check the injury report and final inactives about an hour before tip-off.

What time is Philadelphia 76ers vs Cleveland Cavaliers tonight? 

The Philadelphia 76ers vs Cleveland Cavaliers is scheduled to tip off at 7 pm ET on Friday. 

Where is Philadelphia 76ers vs Cleveland Cavaliers being played? 

The Philadelphia 76ers vs Cleveland Cavaliers will be played at Xfinity Mobile Arena in Philadelphia 76ers, Pennsylvania. 

Where can I watch Philadelphia 76ers vs Cleveland Cavaliers on TV and live stream? 

You can watch Philadelphia 76ers vs Cleveland Cavaliers on ESPN, NBCS-PH, and FDSOH. The live stream will be accessible via NBA League Pass and Fubo. 

Detail Information
DateFriday, January 16, 2026
Time7 pm ET
VenueXfinity Mobile Arena in Philadelphia, Pennsylvania 
TV and Live Stream ESPN, NBCS-PH and FDSON / NBA League Pass, Fubo
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Garima is a sports writer with around two years of experience in Indian sports and a newfound interest in the NBA. Inspired by the leadership of cricketing legend MS Dhoni, she wishes to bring in newer perspectives to the NBA fanatics with her writing.

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