As NFL Week 6 kicks off this Sunday, the league’s landscape continues to shift with injuries, breakout performances, and strategic showdowns that are reshaping divisions. Teams are hitting their strides, or stumbling, midway through the season, where every game carries more stakes for playoff positioning.
In Week 5 we witnessed some upsets, like the Jaguars vs Chiefs game, where rising contenders are now clashing with established powerhouses. This NFL season has also gotten us some under-the-radar talents emerging, and coaches adapting on the fly. Week 6’s Sunday Night Football features a prime time clash between the Chiefs and the Lions, which will gather all the attention and the eyes. However, there’s many more games that we will discuss today and who may potentially come out on top. Stay tuned for what promises to be a pivotal weekend in pro football.
Listed below are all the odds and predictions for the games taking place on Sunday, October 12, 2025, as per BetMGM
To start off Sunday NFL games the New York Jets will take on the Denver Broncos at Northumberland Development Project at London. The Jets, under Aaron Glenn, are off to a 0-5 start to their season so far. Despite changing Aaron Rodgers for Justin Fields, nothing has changed for them even after 5 weeks of NFL football. While the Denver Broncos, 3-2 for the season, shocked the world with a huge win against the Philadelphia Eagles who were undefeated before meeting them.
Prediction: Broncos win the game
The Pittsburgh Steelers who are 3-1 for the season, and are coming off a bye week, will take on the Cleveland Browns. The Steelers, under Aaron Rodgers, have lost only to the Seahawks so far and their offense has been stellar to start the season. Meanwhile, the Browns (1-4) recently traded Joe Flacco to the Bengals and are putting their trust and faith and two rookie QBs in Dillon Gabriel (starter) and backup QB Shedeur Sanders.
Prediction: Steelers win the game
The Indianapolis Colts will take on the Arizona Cardinals for Week 6 action. The Colts have been red hot to start the season (4-1), thanks to Daniel Jones’ breakout year he’s having this season, along with Jonathan Taylor’s rushing game. While the Cardinals are 2-3 for the season, struggling to gather momentum with their QB Kyler Murray leading the way.
| Teams | Spread | Total Points | Moneyline |
|---|---|---|---|
| Cardinals | +7.5 (-110) | 47.5 (-110) | +300 |
| Colts | -7.5 (-110) | 47.5 (-110) | -375 |
Prediction: Colts win the game
The Miami Dolphins will host the Los Angeles Chargers for their Week 6 action. The Dolphins (1-4) are off to a rough start this season, with WR Tyreek Hill’s leg injury that will sideline him for the rest of the year. While the Los Angeles Chargers, after starting out hot, have lost back-to-back games against the Giants and the Commanders.
Prediction: Dolphins win the game
The New Orleans Saints will host the New England Patriots for their Week 6 matchup. The Saints managed to get their first win of the season in Week 5 against the Giants, but other than that, they’ve had a disappointing start to their season with Spencer Rattler leading the way. Meanwhile, the New England Patriots are 3-2 for the season, beating the unbeaten Buffalo Bills in Week 5. The Pats might have found the franchise QB they are looking for in Drake Maye, after his spectacular thrown in Week 5 to WR Stefon Diggs, making things exciting for Patriots fans yet again.
| Teams | Spread | Total Points | Moneyline |
|---|---|---|---|
| Patriots | -3.5 (-110) | 46 (-110) | -190 |
| Saints | +3.5 (-110) | 46 (-110) | +155 |
Prediction: Patriots win the game
The Carolina Panthers are set to take on the Dallas Cowboys for their Week 6 action. The Panthers are 2-3 to start their season and are coming off a Week 5 victory against the Miami Dolphins. With Bryce Young as their QB1, they have yet to find any sort of rhythm so far. Meanwhile the Dallas Cowboys are 2-2-1 this season, winning their last matchup against the New York Jets. They have the best offense in the league statistically, but are on the other end of the spectrum looking at their defense. Dak Prescott is having a great season, but that has not translated to overall team success so far.
Prediction: Panthers win the game
The Jaguars will host the Seahawks for their Week 5 clash. The Jaguars are currently off to a hot start, losing only against the Cincinnati Bengals so far and going 4-1 for the season. They’re coming off an upsetting win over the Kansas City Chiefs, despite the Chiefs’ best efforts with Mahomes leading the way. Meanwhile, the Seattle Seahawks lost to the Tampa Bay Buccaneers in Week 5 as the favorites, and are currently 3-2 for the season.
Prediction: Jaguars win the game
The Baltimore Ravens will take on the L.A Rams for their Week 6 action. The Ravens are now 1-4 and are in serious trouble as they could potentially miss the playoffs, which is unheard of for a team that has been dominant for the past few years under Lamar Jackson. With Jackson still out for this week with a hamstring injury, they will face the L.A. Rams (3-2) who managed to choke a lead last week against the injury riddled San Francisco 49ers.
| Teams | Spread | Total Points | Moneyline |
|---|---|---|---|
| L.A. Rams | -7.5 (-102) | 44.5 (-110) | -400 |
| Baltimore Ravens | +7.5 (-118) | 44.5 (-110) | +310 |
Prediction: L.A Rams win the game
The Tennessee Titans will take on the Las Vegas Raiders for their week 5 matchup. There’s nothing much to say here. Both teams have struggled heavily with Geno Smith leading the league in INTs thrown and Cam Ward still trying to find his way through a tough rookie season. Both teams are 1-4 to start their season and things cannot go any worse for either teams.
| Teams | Spread | Total Points | Moneyline |
|---|---|---|---|
| Titans | +4.5 (-115) | 41.5 (-110) | +180 |
| Raiders | -4.5 (-105) | 41.5 (-110) | -220 |
Prediction: Raiders win the matchup
The Green Bay Packers are set to take on the Cincinnati Bengals. The Packers (2-1-1) started their season strong with a 2-0 start but then lost against the Cleveland Browns and the drew against the Dallas Cowboys in Week 4. While their defense has been stout, their offense with Jordan Love, has looked inconsistent at times. Meanwhile the Bengals (2-3) traded for Joe Flacco after experimenting with backup QB Jake Browning, which led to three straight losses for them.
| Teams | Spread | Total Points | Moneyline |
|---|---|---|---|
| Bengals | +14.5 (-110) | 44.5 (-110) | +775 |
| Packers | -14.5 (-110) | 44.5 (-110) | -1200 |
Prediction: Packers win the game
The Buccaneers face the 49ers for their Week 6 clash. Both the teams are 4-1 for the season and are leading their respective divisions. The 49ers pull off an amazing win against the L.A. Rams in Week 5, despite their injury riddled roster. Meanwhile the Buccaneers are also coming off a win, beating the Seattle Seahawks in a high scoring game. Both the teams have remained resilient this season and are yet to get off their high horse.
| Teams | Spread | Total Points | Moneyline |
|---|---|---|---|
| 49ers | +3.5 (-115) | 47.5 (-105) | +150 |
| Buccaneers | -3.5 (-105) | 47.5 (-115) | -180 |
Prediction: Buccaneers win the game
The Kansas City Chiefs will take on the Detroit Lions for their Week 6 Sunday Night Football matchup. The Chiefs are coming off an upsetting loss to the Jaguars in Week 5 and despite Pat Mahomes’ efforts and Xavier Worthy coming back, they have struggled so far, particularly with inconsistency and lapses on offense and defense. Meanwhile the Lions, after a Week 1 loss to the Packers, have looked unstoppable so far with Jared Goff leading the way. While their defense is still getting polished, their offense is on another level and are looking like serious contenders for Super Bowl this season.
| Teams | Spread | Total Points | Moneyline |
|---|---|---|---|
| Lions | +2.5 (-115) | 53 (-110) | +115 |
| Chiefs | -2.5 (-115) | 53 (-110) | -135 |
Prediction: Lions win the game
If you’re looking for a complete guide to the best NFL betting sites, we’ve got you covered.
Here are some of the best underdog picks for Week 6, according to BetMGM.
The Miami Dolphins can pull off an upset against the L.A. Chargers simply because the Chargers are on a two game losing streak, to the Commanders in Week 5 and to the New York Giants in Week 4. Their loss against the Giants was very strange and odd to see, even though the Chargers had every weapon at their disposal and still could not get the job done. Justin Herbert, as great as he is, can be inconsistent with his production, and if the Dolphins manage to contain the Chargers’ passing game, it might just be enough.
If Bryce Young is able to produce and not turn the ball over, the Panthers have a solid chance to beat the Dallas Cowboys. While the Cowboys are excellent offensively, defensively they are the worst team in the NFL currently, ranking 32nd in total defense and 32nd in passing defense. The Panthers on the other hand are top 10 in passing defense and 12th in total defense, which could help them potentially contain Dak Prescott’s offensive game.
The Detroit Lions have been a far superior team this season, compared to the Kansas City Chiefs, who started off 0-2, won the next two games, and again dropped a game in Week 5 to the Jaguars. Defensive and offensive inconsistency has killed their rhythm so far, and there is no reason for us to believe that will change tonight, especially against one of the best teams in the NFL currently. Expect the Lions to take home the victory, with their offense being far superior to the Chiefs.
| Teams | Spread | Total Points | Moneyline |
|---|---|---|---|
| Lions | +2.5 (-115) | 53 (-110) | +115 |
| Chiefs | -2.5 (-115) | 53 (-110) | -135 |
(According to BetMGM: BetMGM offers exclusive promo codes, bonus deals and accurate odds for users upon signing up. Use BetMGM to ace your betting game in all sports!)
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