Lyon vs Manchester United Preview, Team News, Odds & Predictions – 04/10/2025

Lyon, officially known as Olympique Lyonnais, will host the 2016-17 UEFA Europa League Champions, Manchester United, at the Parc Olympique Lyonnais in Lyon on Thursday, April 10, for the first leg of the two-legged quarter-final in the 2024-25 Europa League.

The two clubs have met in European competitions on four occasions, with United unbeaten till now with a record of 2 wins and 2 draws against the French club.

Learn more about the odds, team news, picks, and predictions for the thrilling first leg of the UEFA Europa League quarter-final clash between Lyon and Manchester United:

Where to watch Lyon vs Manchester United

Here is when and where to watch the clash between Lyon and Manchester United.

Date: 04/10

Time: 3 pm ET

Location: Parc Olympique Lyonnais, Lyon

Where to watch: The match can be watched on Paramount+ and CBS Sports Network in the USA

Lyon vs Manchester United Preview

Manchester United head coach Ruben Amorim seems to have sorted out the issues with the formation and playing style as of late, but the Portuguese manager feels that it will be a different kind of battle on Thursday.

He said, “It’s going to be different against Lyon, because they play in a league that is so physical, like ours. We have to find different ways of winning those games and we’ll be ready for that.”

Lyon

Lyon started the 2024-25 Europa League season on a positive note with two consecutive wins, but a defeat and three draws in their subsequent six matches left them in the sixth position on the league standings. The French club was totally ruthless when they met FCSB in the Round of 16 and thrashed them 7-1 on aggregate, setting up a quarter-final against Amorim’s men.

Lyon is currently involved in an intense battle for the Champions League spots as only six points separate Marsielle in 2nd position and LOSC Lille in 7th position with only six matchdays left in the Ligue 1 season, leaving OL to divert their attention on both fronts over the coming weeks. Malick Fofana and Ernest Numuah will not feature in the home leg against Manchester United due to their respective injuries while A

Predicted Starting XI: Perri; Maitland-Niles, Mata, Niakhaté, Tagliafico; Tessman, Matić; Cherki, Tolisso, Almada; Mikautadze

Manchester United

The Red Devils were the only team to remain unbeaten throughout the league stage of the ongoing Europa League campaign, drawing their first three matches and then going on a five-match winning streak to finish third in the league standings. United then brushed aside the challenge from Real Sociedad as they beat the Spaniards 5-2 on aggregate in the Round of 16.

Amorim’s men are currently 13th in the league standings and won’t gain anything from fighting it out on the domestic front except for salvation as they would be looking to avoid a first bottom-half finish in Premier League history for the celebrated club. While Lisandro Martinez, Ayden Heaven, Jonny Evans, and Amad Diallo remain unavailable, Luke Shaw might feature for a few minutes after making it to the bench in the Manchester Derby.

Predicted Starting XI: Onana; Yoro, de Ligt, Maguire; Dalot, Casemiro, Fernandes, Dorgu; Zirkzee, Hojlund, Garnacho

Lyon vs Manchester United Under/Over Predictions

The Playoffs aim to facilitate the safest bets for the game. Have a look at the predictions for the game below.

Total goals Over 2.5 @ -121 (MGM Bet): Lyon has one of the best offensive records with Alexandre Lacazette, Georges Mikautadze, and Ryan Cherki banging in the goals for the French club, but United’s newly found defensive resilience might prove to be a factor on Thursday.

Lyon vs Manchester United Player Picks

Bruno Fernandes (To Score a Goal @ +225 as per MGM Bet): The leading goalscorer for Manchester United in the 2024-25 season, Bruno Fernandes has 7 goal contributions in 9 matches in Europe’s second-tier competition this season and Amorim would be hoping that his skipper can deliver the goods to help them secure a trophy at the end of the season.

Lyon vs Manchester United Prediction

Many fans and pundits would be backing Lyon, owing to their strong form in both league and Europe, but one can never discount the might of the Red Devils, who could still destroy oppositions on a good day.

Our Final Prediction: A 2-1 win for Lyon would set up the tie perfectly ahead of the second leg at Old Trafford and given the fact that Lyon has never lost to United at home certainly boost their chances for Thursday.

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Mohak Arora

A stand-up comedian and a sports journalist with speciality in writing prediction pieces and features on football, cricket, and badminton. Over the last few years, I have contributed pieces to iGaming giants like Parimatch, 1X News, and Melbet.