Liverpool vs Southampton Preview, Betting Odds and Predictions – 23/09/25

Liverpool are set to kick off their EFL Cup campaign at Anfield against Championship side Southampton on Tuesday night. The Reds are entering the match in excellent form. They’re sitting top of the Premier League table with a perfect start to their 2025-26 season.

Arne Slot’s men have combined attacking flair with resilience. They’ve scored consistently but showed occasional defensive lapses. Despite those setbacks, they remain unbeaten across all competitions, and Anfield has proven a fortress once again. Liverpool now aim to carry that momentum into the domestic cup competition.

Liverpool vs Southampton Best Bets

Liverpool vs Southampton Preview

Liverpool

Arne Slot is expected to rotate his squad, resting several key players who have featured heavily so far. Dominik Szoboszlai, Mohamed Salah, Ryan Gravenberch, Ibrahima Konate and Virgil van Dijk are all expected to sit out. Giorgi Mamardashvili should start in goal.

He should be supported by Joe Gomez and Giovanni Leoni in defence. Teenage midfielder Trey Nyoni is in contention to partner Wataru Endo. Meanwhile Federico Chiesa could operate on the right flank. Slot is likely to use the tie to test depth options to maintain freshness across the squad.

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Southampton

Southampton boss Will Still is expected to set his side up with a back three in an attempt to keep Liverpool at bay. Ronnie Edwards, Nathan Wood and Jack Stephens should feature in central defence. Flynn Downes missed the Hull clash through illness but may return to regain sharpness in midfield.

The Saints’ form has been underwhelming so far. They’ve managed only one win from their last six matches. And they have also often struggled on the road. Nonetheless, last season’s EFL Cup quarter-finalists will look to rediscover momentum against top-flight opposition.

Liverpool vs Southampton Over/ Under Predictions

Total Goals Over 3.5 @ -130 as per BetMGM:

Liverpool’s attacking form this season supports expecting over 3.5 goals. They’ve scored 14 goals in their first six matches across competitions. They’ve also found the net in every Premier League game so far. Playing at home, the coach could opt for rotation.

Even so, still loaded with offensive talent, they are positioned to score freely. Southampton, from a lower division, have shown defensive frailties. They’ve conceded heavily in recent fixtures. Thus, making a high-scoring clash probable. At -130, this line reflects the possible scoreline justifiably. 

Liverpool vs Southampton Player Picks

Federico Chiesa to score anytime @ +115 as per FanDuel:

Federico Chiesa has delivered some encouraging early signs this season. He scored his first Premier League goal for Liverpool in the dramatic 4-2 win over Bournemouth. He netted late after coming off the bench. Some senior attackers will be set to rest in this game.

Hence, Chiesa could be pushed forward, especially on the right flank. Given that rotation, and his knack for impactful moments off the bench, +115 offers decent value for him to score anytime against Southampton.

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Alexander Isak to either score or assist anytime @ -270 as per FanDuel:

Isak, Liverpool’s big summer signing, hasn’t fully settled yet. However, his attacking presence has already been noted. With games crowded due to Liverpool’s fixture load, he is likely to get chances in forward positions. 

Given injuries or rest for others, Isak may lead the line. And his opportunity to score or set up a goal is strong. At -270, this odds reflects both confidence in Liverpool’s attack and Isak’s potential impact when given minutes in big matches.

Liverpool vs Southampton

Liverpool vs Southampton Predictions

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The Reds should dominate possession, generate multiple scoring chances, and capitalize on Southampton’s defensive lapses. It’s true that Liverpool’s defense has shown occasional wobbliness, having thrown away leads recently. However, they are unlikely to be kept off the scoresheet at home in this game. Southampton may manage a consolation goal, perhaps from counterattacks or set pieces.

Final Prediction: Liverpool 3-1 Southampton

Liverpool’s firepower at Anfield should be enough to pull clear with a convincing performance. Taking all this into account, a 3-1 win for Liverpool seems the likeliest outcome.

Moumita Dutta

soccer

Football writer at The Playoffs. I’ve been obsessed with the beautiful game since I was a kid.. Eventually, I realized I could combine my passion for writing with my love for football, and I’ve never looked back. My favorite part of the job is everything—when you’re doing what you love, even a late-night deadline feels like extra time in a thrilling cup final. Lastly, Lionel Messi is the GOAT.

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