Mandatory Credit: Peter van den Berg-USA TODAY Sports

Karen Khachanov vs. Mackenzie McDonald Head to Head Record, Preview, Prediction and Betting Odds for 2025 Wimbledon First Round

Mackenzie McDonald can deliver another heroics of Hertogenbosch with clean footwork, and sharp take-backs.

Mandatory Credit: Peter van den Berg-USA TODAY Sports

Karen Khachanov will take on the American ace, Mackenzie McDonald in the opening round clash of the 2025 Wimbledon at Court No. 18. The Russian enter the tournament as the top-20 player and look to cross the quarterfinals this time. On the other hand, Mackenzie McDonald is ready to face Khachanov for the second time in the gap of three weeks.

Also Read: Andrey Rublev vs Laslo Djere Head-to-Head Record, Preview, Prediction, and Betting Odds for Wimbledon 2025 First Round

Karen Khachanov vs. Mackenzie McDonald Preview

Karen Khachanov has been a consistent player on grass court with a 6-2 record this year. The Russian ace had a semifinal run in Halle and quarterfinal run in Hertogenbosch. He overcame Novak Djokovic in straight sets at the exhibition last week which can boost his confidence ahead of the season’s third Grand-Slam.

Karen Khachanov defeated Novak Djokovic 7-6(4), 6-4 at the Hurlingham Classic in London. pic.twitter.com/4DZR3HSuDL
— José Morgado (@josemorgado) June 27, 2025

The 29-year-old’s best run at Wimbledon came in 2021 when he made into the quarterfinals. Khachanov reached the quarterfinals at all four Grand Slam events. The Russian ace is 5-0 in the first round of Wimbledon championship which also includes a victory over Mackenzie McDonald. However, he has gone 0-9 against top-20 players this year.

Mackenzie McDonald is coming through a recovery from the injury. He went out of the top 100 and then improved this year with a ranking of No. 90. The American ace is 6-4 on the grass court this year which includes the victory against Monfils and Bellucci. However, he is yet to win a game in the main-draw of a Grand Slam competition since 2023 US Open. His one first-round loss also came against Khachanov in 2021. He reached the round of 16 in 2018 Wimbledon but gone 1-4 in London since then.

NO WAY 🤯

An outrageous volley from Mackenzie McDonald as he snatches the second set against Khachanov, 7-5!@LibemaOpen | #LibemaOpen pic.twitter.com/Jizbz7Dli2
— ATP Tour (@atptour) June 11, 2025

Karen Khachanov vs. Mackenzie McDonald Head to Head Record

Karen Khachanov holds a dominating 5-0 lead over Mackenzie McDonald in the ATP H2H meetings. The Russian ace also defeated McDonald in the Wimbledon four years ago in a competitive four-set thriller. The duo also met in the round of 16 at Hertogenbosch this month and the winner was decided through tie-break in final set. Khachanov won both grass-court matchups against the American ace.

Year	Event	Round	Winner	Score
2025	Hertogenbosch	Round of 16	Karen Khachanov	6-3, 5-7, 7-6(4)
2023	Zhuhai	Quarterfinals	Karen Khachanov	4-6, 6-4, 6-4
2022	Doha	Round of 32	Karen Khachanov	7-6(3), 6-3
2021	Wimbledon	Round of 128	Karen Khachanov	3-6, 6-3, 6-4, 7-6(3)
2021	Marseille	Round of 16	Karen Khachanov	7-6(4), 6-4

Karen Khachanov vs. Mackenzie McDonald Career Comparison

Karen Khachanov	Category	Mackenzie McDonald
19	Ranking	90
299- 216	Career W-L	111–132
20-15	YTD W-L	22-16
7	Career Titles	0
0	Grand Slams	0
0	YTD Titles	0

Karen Khachanov vs. Mackenzie McDonald Wimbledon 2025 Prediction

Karen Khachanov has gone fearless against Mackenzie McDonald as he won all five matches against the American ace. The Russian star is pumped up and his groundstrokes on grass will trouble McDonald. However, the American ace came close to defeat Khachanov at Hertogenbosch but lost the decider set on tie-break. McDonald has solid grass instincts but Khachanov has the experience of handling the pressure.

Prediction: Khachanov to win in straight sets.

Karen Khachanov vs. Mackenzie McDonald Wimbledon 2025 Betting Odds

According to the implied probability on the money line, Karen Khachanov starts with a 70% chance of crack the opening round. Here are the odds for the match (as per BetMGM):

Madison Keys Win: 1/4
Mackenzie McDonald Win: 10/3

At 1/4, Karen Khachanov looks clear favorite, considering his H2H dominance and grass-court form. Mackenzie McDonald, at 10/3, can deliver another heroics of Hertogenbosch with clean footwork, and sharp take-backs. Still, the odds back the Russian ace to prevail.

Here are the odds for total games as well as total sets for both players (sourced via BetMGM):

Total Games Over 34.5: 21/50
Total Games Under 34.5: 7/4
Set 1 winner: Khachanov– 1/2, McDonald– 21/10
Set 2 winner: Khachanov– 5/12, McDonald– 2/1
Total Sets Under 2.5: 7/19
Total Sets Over 2.5: 5/2

(All Odds According to BetMGM: BetMGM offers exclusive promo codes, bonus deals and accurate odds for users upon signing up. Use BetMGM to ace your betting game in all sports!)

Mandatory Credit: Peter van den Berg-USA TODAY Sports

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