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Atlanta Falcons vs Buffalo Bills Predictions, Odds, and Best Bets for Week 6 MNF of the 2025-26 NFL Season

Eric Divakaran
American Football / NFL
14/10/2025 – 00:15
Atlanta Falcons
VS
00:15
14/10/2025
Buffalo Bills
Odds updated on October 13, 2025 at 4:41 pm

The Atlanta Falcons are set to face the Buffalo Bills for Week 6’s Monday Night Football action live from Mercedes-Benz Stadium, home of the Falcons. The Falcons coming into this game with a 2-2 record, with a bye week in Week 5. They, under Michael Penix Jr, have been a bit of a confusing team this season, ranking No.1 in total defense and 7th in total offense. However, they were completely shut out against a bottom ranked team in Carolina Panthers in Week 3, but won against the Washington Commanders in Week 4. Are they a playoff contending team? We cannot say just yet.

The Buffalo Bills on the other hand, were undefeated until Week 5 but lost to the New England Patriots last week. They are 4-1 for the season, thanks to their homefield advantage and Josh Allen’s continued success after his MVP campaign last season. In Week 5 we saw a significant hole for the Bills and came to a conclusion that if the Bills do not score the ball enough, they will always be in danger to lose the match. Bills rank No.3 in total offense and have been stellar, but struggle with defensive inconsistency. While Bills are some of the best teams, they have the same problem as last season, which makes us question their playoff chances.

Recommended Bets and Updated Odds

Recommended BetsFanDuelBetMGM
Bijan Robinson anytime touchdown scorer-180-175
James Cook anytime touchdown scorer-155-175
Total TDs over 5.5 -148-120
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Rationale and Analysis

The Buffalo Bills are one of the worst teams in the NFL in terms of rushing defense and the Falcons will look to exploit this using thier running back, Bijan Robinson. Robinson has rushed for 314 yards already, but has one TD in this season, coming in Week 4 against the Commanders. Hence, it is a safe bet to assume Robinson will score at least one TD.

James Cook is a threat to score at anytime looking at the number of touches he gets during a game. He’s had 13 or more rush attempts in every game so far, and has had 3 games over 100 rushing yards. He’s scored in every game except in Week 5 and looking at him as the primary go-to weapon, it is safe to assume that Cook will score a TD in this game.

Both the Buffalo Bills and the Atlanta Falcons are one of the best teams offensively, with the Falcons ranking 7th in total offense, 13th in passing offense, and 6th in rushing offense. While the Buffalo Bills rank 2nd in rushing offense, 7th in passing offense, and 3rd in total offense.

Falcons vs Bills Predictions

We expect the Buffalo Bills to take down the Atlanta Falcons, because of their offensive surge, and looking at the Falcons’ inconsistent offense. While defensively, the Bills are very vulnerable, their offense should be enough to take down the Falcons. However, we expect this game to be extremely close.

Prediction: Buffalo Bills win the game 35-28

Week 6 MNF Falcons vs Bills Spread and Betting Odds

Looking at the spread and the moneyline, the Buffalo Bills are the favorites to win the game against the Atlanta Falcons, as per BetMGM

TeamsSpreadTotal PointsMoneyline
Bills -4 (-110)50 (-110)-210
Falcons+4 (-110)50 (-110)+170
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Falcons vs Bills Best Bets

Here are over/under and best player bets for the Atlanta Falcons and the Buffalo Bills, as per BetMGM

Atlanta Falcons Over/Under Odds

Listed below are some of the over/under odds for the Atlanta Falcons, as per BetMGM

Over/Under BetsOverUnder
Michael Penix Jr. passing yards 227.5 (-115)227.5 (-115)
Drake London receiving yards 72.5 (-118)72.5 (-115)
Bijan Robinson rushing yards74.5 (-115)74.5 (-115)

Atlanta Falcons Best Player Bets

Here are some of the best player bets for the Atlanta Falcons, as per BetMGM

  • Michael Penix Jr. under 1.5 passing TDs: -155
  • Bijan Robinson anytime TD scorer: -175
  • Drake London anytime TD scorer: +150

Buffalo Bills Over/Under Odds

Here are over/under for the Buffalo Bills, as per BetMGM

Over/Under BetsOverUnder
Josh Allen passing yards 227.5 (-115)227.5 (-115)
James Cook rushing yards 71.5 (-118)71.5 (-110)
Khalil Shakir receiving yards47.5 (-110)47.5 (-118)

Buffalo Bills Best Player Bets

Below listed are some of the best player bets for the Buffalo Bills, as per BetMGM

  • Josh Allen over 1.5 passing touchdowns: -130
  • Josh Allen under 0.5 interception thrown: -145
  • James Cook anytime TD scorer: -175
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FAQs

Who is favored to win between the Bills vs Falcons?
The Bills are 4-point favorites to win the matchup against the Falcons.

What is the over/under total for the game?
The over/under for total points is set at 50.

What is the predicted score for the Bills vs Falcons game?
We expect the Bills to take down the Falcons, and the Final score to be 35-28

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I cover the National Football League and things cannot get better than that. I always dreamed to play football or basketball professionally since I’m built like a Running Back. But now that I can’t, since I’m technically in the “Unc” age, I thought why not pick a career in sports industry? So here I am, doing what I love, and hoping that the Commanders win the Super Bowl. I give love to players when it’s due, but can be critical about their performances at the same time. Enough about me, now let my articles do all the talking. 

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