The Indiana Pacers (15‑54) travel to Frost Bank Center to face the red‑hot San Antonio Spurs (46‑23) on Saturday night in a matchup that looks heavily tilted toward the home team. Indiana has lost 15 straight and continues to struggle on both ends of the floor, ranking 28th in scoring and 25th in defense.
San Antonio, meanwhile, has won nine of their last ten and four straight, powered by Victor Wembanyama’s dominance and De’Aaron Fox’s scoring. The Spurs average 123.6 points per game while holding opponents to just 110.2, showcasing their balance.
Injuries loom large: Indiana is dealing with a long list of day‑to‑day players including Tyrese Haliburton, Pascal Siakam, and Obi Toppin, while San Antonio is monitoring Stephon Castle and David Jones. Oddsmakers have San Antonio favored by 18.5 points, with the total set at 233.
Best Bet: Spurs -18.5 (-110) at BetMGM Sportsbook
San Antonio’s dominance and Indiana’s struggles make the Spurs the sharper side to back. The Spurs have won 11 of their last 12 at home and are 9‑1 SU in their last 10 overall. Their offense ranks sixth in scoring at 118.5 points per game, while Indiana’s defense ranks 25th, allowing nearly 119 points per contest.
The Pacers have lost 10 straight SU and are 0‑8 ATS in their last eight road games, making them difficult to trust even with a large spread. While the total of 233 leans toward the over given Indiana’s recent trends, San Antonio’s defensive efficiency suggests the under could be in play.
Still, the spread is the sharper angle, and Spurs -18.5 is the best bet given their momentum, ATS trends, and Indiana’s inability to compete against elite teams.
This safer parlay leans on both stars to hit their averages while banking on the under, which ties in with San Antonio’s defensive strength and Indiana’s offensive inconsistency.
The longshot parlay hinges on Wembanyama stretching the floor, Castle facilitating at a high level, and San Antonio pulling away late. Given Indiana’s recent form, this scenario is plausible.
| Team | Spread | Moneyline | Total |
|---|---|---|---|
| Pacers | +18.5 (-110) | +1200 | O 233 (-110) |
| Spurs | -18.5 (-110) | -3000 | U 233 (-110) |
Odds updated: March 21, 2026 – 1:00 p.m. ET. Lines may move throughout the day.
| Team | Player | Injury | Status |
|---|---|---|---|
| Pacers | T.J. McConnell | Hamstring | Day to day |
| Pacers | Pascal Siakam | Knee | Day to day |
| Pacers | Ivica Zubac | Rib | Day to day |
| Pacers | Obi Toppin | Foot | Day to day |
| Pacers | Tyrese Haliburton | Achilles | Day to day |
| Pacers | Aaron Nesmith | Ankle | Day to day |
| Pacers | Micah Potter | Triceps | Day to day |
| Pacers | Andrew Nembhard | Calf | Day to day |
| Pacers | Quenton Jackson | Calf | Day to day |
| Pacers | Ben Sheppard | Ankle | Day to day |
| Pacers | Johnny Furphy | ACL | Day to day |
| Spurs | Stephon Castle | Hip | Day to day |
| Spurs | David Jones | Ankle | Day to day |
The game tips off at 8:00 p.m. ET on Saturday, March 21, 2026.
The matchup will be held at Frost Bank Center in San Antonio, Texas.
The game will be broadcast nationally on ESPN, with streaming available via NBA League Pass.
| Detail | Info |
|---|---|
| Date | Saturday, March 21, 2026 |
| Time | 8:00 p.m. ET |
| Arena | Frost Bank Center, San Antonio, TX |
| TV/Streaming | ESPN / NBA League Pass |
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