Philadelphia Eagles vs Denver Broncos Preview, Prediction, and Betting Odds – Week 5 NFL 2025-26 Season

The Philadelphia Eagles are set to take on the Denver Broncos for Week 5’s AFC West vs NFC East matchup. The Eagles are still undefeated going into this matchup, while the Broncos are currently at .500, winning two games and losing two. It’s a battle of quarterbacks as Broncos Bo Nix will face Eagles’ Jalen Hurts.

Eyes on Denver@TJUHospital | #FlyEaglesFly pic.twitter.com/p20IEODB9N
— Philadelphia Eagles (@Eagles) October 2, 2025

The Eagles have been rolling this season, and despite some of their internal issues, they have not slowed down. They have faced tough competition thus far and have come out on top every single time, showing why they are the Super Bowl champs. Meanwhile, the Broncos, are coming into this game after thoroughly beating the Cincinnati Bengals, holding them to just 3 points.

Recommended Bets	FanDuel	BetMGM
Saquon Barkley Anytime TD scorer	-155	-175
Bo Nix over 214.5 passing yards	-114	-115
Total Touchdowns under 4.5	+128	+100

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Rationale and Analysis

While Saquon Barkley has had a very slow start to his 2025/26 season, he has scored TDs in 3 out of 4 games so far, totaling 3 touchdowns for the season so far. The Broncos have been excellent defensively so far, but their rushing defense is still out of top 10, ranking 11th in the league. The amount of touches Barkley gets, and that he’s the Eagles’ go-to option on most drives, makes him a threat to score a TD at anytime.

The Eagles have not been the same team defensively, like they were last season which allowed them to win the Super Bowl. Bo Nix is coming off a 326 yards performance against the Bengals, and while you may think that it’s the “Eagles,” the champs currently rank 22nd in total defense and 15th in passing defense. And if the game gets close, you can expect Nix to go in all-out passing mode, potentially crossing 214.5 passing yards.

The Broncos are elite defensively, ranking 8th in total defense, 8th in passing defense, 11th in rushing defense, and 2nd in scoring defense. While the Eagles rank 3rd in red zone defense, 15th in scoring defense, 15th in passing defense. Both teams are known for their defensive pressure, which is why we believe total TDs will be under 4.5.

Eagles vs Broncos Preview

The Eagles are set to take on the Broncos for their Week 5 matchup. And we will see Saquon Barkley and Jalen Hurts try to lead their team to a 5-0 start for the season. Meanwhile, the Broncos and Bo Nix are 2-2 for the season, coming off a dominant win in Week 4, but losing to the Chargers in Week 3. Both teams are known for their defense, and it will be interesting to see who takes home the victory, while expecting a low scoring game.

Final prep before wheels up 🏈 pic.twitter.com/VSGwz8Hwo4
— Denver Broncos (@Broncos) October 3, 2025

Eagles vs Broncos Prediction

As the defending Super Bowl champions enter undefeated but have show vulnerabilities, particularly in their passing game and inconsistent second-half performances, though they’ve won close games via defense, turnovers, and special teams.

While the Broncos have been excellent defensively, their offense ranks low in efficiency, but momentum from last week could help against Philly’s secondary. While the Betting odds favors the Eagles, Philly has struggled with their defense, A.J. Brown’s frustration with lack of involvement, adds intrigue to this matchup.

Prediction: Eagles win 24-17

Eagles vs Broncos Betting Odds

Here are over/under and best player bets for the Philadelphia Eagles and the Denver Broncos, according to BetMGM

Philadelphia Eagles Over/Under Odds

Below listed are over/under for the Philadelphia Eagles, as per BetMGM

Over/Under Bets	Over	Under
Jalen Hurts Passing Yards	193.5 (-118)	193.5 (-115)
A.J. Brown Receiving yards	58.5 (-115)	58.5 (-115)
Saquon Barkley Rushing Yards	79.5 (-115)	79.5 (-115)

Philadelphia Eagles Best Player Bets

Here are some of the best player bets for the Philadelphia Eagles, according to BetMGM

Saquon Barkley anytime TD scorer: -175
Jalen Hurts Under 1.5 passing TDs: -275
Jalen Hurts interceptions thrown under 0.5: -190

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Denver Broncos Over/Under Odds

Below listed are over/under for the Denver Broncos, according to BetMGM

Over/Under Bets	Over	Under
Bo Nix Passing Yards	214.5 (-115)	214.5 (-115)
J.K. Dobbins Rushing Yards	49.5 (-115)	49.5 (-115)
Courtland Sutton Receiving Yards	56.5 (-115)	56.5 (-115)

Denver Broncos Best Player Bets

Here are some of the Best Player Bets for the Denver Broncos, according to BetMGM

Bo Nix 1.5 passing touchdowns: -190
Bo Nix over 0.5 interception thrown: -150
Courtland Sutton under 4.5 reception made: -125

Eagles vs Broncos Spread and Betting Odds

Looking at the spread and the moneyline, the Eagles are the slight favorites to win the matchup against the Denver Broncos, according to BetMGM

Teams	Spread	Total Points	Moneyline
Broncos	+4 (-110)	43.5 (-110)	+180
Eagles	-4 (-110)	43.5 (-110)	-220

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FAQs

Who is favored to win between the Eagles and the Broncos?
The Philadelphia Eagles are 4-point favorites to win the matchup against the Broncos

What is the over/under total for the game?
The over/under for total points is set at 43.5.

What is the predicted score for the Eagles vs Broncos game?
Eagles are predicted to win the game, 24-17.

Eric Divakaran

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I cover the National Football League and things cannot get better than that. I always dreamed to play football or basketball professionally since I’m built like a Running Back. But now that I can’t, since I’m technically in the “Unc” age, I thought why not pick a career in sports industry? So here I am, doing what I love, and hoping that the Commanders win the Super Bowl. I give love to players when it’s due, but can be critical about their performances at the same time. Enough about me, now let my articles do all the talking.