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The Bills are the slight favorites against the Broncos in this Divisional round matchup.
The first game of the Divisional round pits the Denver Broncos against the Buffalo Bills in what should be an exciting matchup between two top AFC teams.
On one side, the Broncos are coming into the game off a bye as the number one seed in the AFC, while the Bills are coming into the game on the back of a thrilling road win against the Jacksonville Jaguars in the Wild Card round.
The key to this exciting matchup will be Denver’s dominant defense against Buffalo’s offensive prowess, led by Josh Allen under center.
The table below gives the opening odds for the Broncos vs Bills matchup as per FanDuel.
| Spread | Moneyline | Total | |
|---|---|---|---|
| Denver Broncos | +1.5 (-110) | +104 | O 46.5 (-110) |
| Buffalo Bills | -1.5 (-110) | -122 | U 46.5 (-110) |
The opening odds for the Broncos vs Bills Divisional round matchup show that the Bills are the slight favorite to win the game.
Here are our early picks for the Divisional game between the Broncos and the Bills.
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For the Broncos vs Bills Divisional game, we are leaning towards the Bills to win and cover the spread despite being on the road. The Broncos are one of the elite teams on defense, but the offense hasn’t lived up to the same standards. Second-year quarterback Bo Nix has done well to do what is required to get wins, but it may not be enough against this Bills team.
Buffalo, on the other hand, runs its offense through Josh Allen and running back James Cook. The Bills’ quarterback has had another fine season as a dual-threat passer with 25 passing and 14 rushing touchdowns this season.
In the previous game against the Jaguars, Allen once again showed why he is the reigning MVP with a total of 3 touchdowns. The defense, however, hasn’t been as sharp this season, allowing 21.5 points per game.
While the Broncos are one of the best defensive units in the game, they are going up against one of the top scoring offenses in the league. In fact, the Bills’ offense regularly put up more than 25 points a game, averaging 28.3 throughout the season.
Buffalo was also impressive against Jacksonville as the offense scored 3 touchdowns and put up 27 points in their win. Denver’s offense has also averaged just a little under 24 points per game this season.
For the early player prop in this Broncos vs Bills game, we are leaning towards James Cook being held to under 81.5 rushing yards in the upcoming game. The main reason for this is the Denver run defense, which ranks second in the league, allowing just a tad over 91 rushing yards per game.
Additionally, Cook has not crossed 80 rushing yards in his last three games and was even held to just 46 yards on the ground against Jacksonville.
Here are some of the key trends to monitor for the Broncos’ Divisional game against the Bills.
As the number one seed in the AFC, the Denver Broncos clearly have the added advantage of extra rest and home-field support. Moreover, the Broncos have an elite defense that led the league in total sacks on the year. However, the offense will need to step up if it is to win the game.
As for the Bills, they are on the road this year after losing their AFC East crown to the Patriots. However, that didn’t stop them from taking care of business against the Jaguars in the last game. Josh Allen is the man to pay attention to. If the Broncos can stop him, they can stop the Bills.
Our prediction: Buffalo Bills win
The details for the Broncos vs Bills AFC Divisional round game are as follows.
| Game Details | Information |
|---|---|
| Date | Saturday, January 17, 2026 |
| Kickoff | 4:30 p.m. ET |
| Location | Empower Field at Mile High, Denver, Colorado |
| TV | CBS |
| Streaming | Paramount+, NFL+ (mobile) |
The Denver Broncos take on the Buffalo Bills on Saturday, January 17, 2026 at 4:30 p.m. ET.
This Divisional round matchup between the Broncos and the Bills will take place at Empower Field at Mile High, Denver, Colorado.
The Broncos vs Bills game will be telecast on CBS with live streaming available on platforms such as FuboTV, Paramount+, YouTube TV (with NFL Sunday Ticket), and on NFL+ (mobiles and tablets).
The above odds are sourced from FanDuel. Use FanDuel to ace your betting game in all sports!
Mandatory Credit: Imagn Images [Corey Perrine/Florida Times-Union]
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