NFL Divisional Round Lookahead – Denver Broncos vs Buffalo Bills Rams Opening Odds, Early Picks & Predictions

The Bills are the slight favorites against the Broncos in this Divisional round matchup.

The first game of the Divisional round pits the Denver Broncos against the Buffalo Bills in what should be an exciting matchup between two top AFC teams.

On one side, the Broncos are coming into the game off a bye as the number one seed in the AFC, while the Bills are coming into the game on the back of a thrilling road win against the Jacksonville Jaguars in the Wild Card round.

The key to this exciting matchup will be Denver’s dominant defense against Buffalo’s offensive prowess, led by Josh Allen under center.

What are the opening odds for the Broncos vs Bills?

The table below gives the opening odds for the Broncos vs Bills matchup as per FanDuel.

	Spread	Moneyline	Total
Denver Broncos	+1.5 (-110)	+104	O 46.5 (-110)
Buffalo Bills	-1.5 (-110)	-122	U 46.5 (-110)

The opening odds for the Broncos vs Bills Divisional round matchup show that the Bills are the slight favorite to win the game.

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Officially official.#BUFvsDEN will kick off this Saturday at 2:30pm MT on CBS! pic.twitter.com/WTfCOY13bt
— Denver Broncos (@Broncos) January 13, 2026

Early picks & predictions for Broncos vs Bills

Here are our early picks for the Divisional game between the Broncos and the Bills.

Early spread lean: Buffalo Bills -1.5 (-110)
Early total lean: Over 46.5 (-110)
Early player prop: James Cook Under 81.5 rushing yards (-114)

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Early leans & betting predictions

Early spread lean: Buffalo Bills -1.5 (-110)

For the Broncos vs Bills Divisional game, we are leaning towards the Bills to win and cover the spread despite being on the road. The Broncos are one of the elite teams on defense, but the offense hasn’t lived up to the same standards. Second-year quarterback Bo Nix has done well to do what is required to get wins, but it may not be enough against this Bills team.

Buffalo, on the other hand, runs its offense through Josh Allen and running back James Cook. The Bills’ quarterback has had another fine season as a dual-threat passer with 25 passing and 14 rushing touchdowns this season.

In the previous game against the Jaguars, Allen once again showed why he is the reigning MVP with a total of 3 touchdowns. The defense, however, hasn’t been as sharp this season, allowing 21.5 points per game.

Early total lean: Over 46.5 (-110)

While the Broncos are one of the best defensive units in the game, they are going up against one of the top scoring offenses in the league. In fact, the Bills’ offense regularly put up more than 25 points a game, averaging 28.3 throughout the season.

Buffalo was also impressive against Jacksonville as the offense scored 3 touchdowns and put up 27 points in their win. Denver’s offense has also averaged just a little under 24 points per game this season.

Early player prop: James Cook Under 81.5 rushing yards (-114)

For the early player prop in this Broncos vs Bills game, we are leaning towards James Cook being held to under 81.5 rushing yards in the upcoming game. The main reason for this is the Denver run defense, which ranks second in the league, allowing just a tad over 91 rushing yards per game.

Additionally, Cook has not crossed 80 rushing yards in his last three games and was even held to just 46 yards on the ground against Jacksonville.

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Trends to Monitor

Here are some of the key trends to monitor for the Broncos’ Divisional game against the Bills.

The Broncos are 8-9 ATS this season.
Denver is 6-3 ATS at home this season.
The Bills are 5-4 ATS on the road this season.
Buffalo is 8-10 ATS this season.
The Under for the Broncos is 10-7 this season.
The Under for the Bills is 10-8 this season.

Early prediction summary

As the number one seed in the AFC, the Denver Broncos clearly have the added advantage of extra rest and home-field support. Moreover, the Broncos have an elite defense that led the league in total sacks on the year. However, the offense will need to step up if it is to win the game.

As for the Bills, they are on the road this year after losing their AFC East crown to the Patriots. However, that didn’t stop them from taking care of business against the Jaguars in the last game. Josh Allen is the man to pay attention to. If the Broncos can stop him, they can stop the Bills.

Our prediction: Buffalo Bills win

The date and time is set. 👀@NorthtownAuto | #BillsMafia pic.twitter.com/e5jOAXWcoK
— Buffalo Bills (@BuffaloBills) January 13, 2026

How to watch Broncos vs Bills

The details for the Broncos vs Bills AFC Divisional round game are as follows.

Game Details	Information
Date	Saturday, January 17, 2026
Kickoff	4:30 p.m. ET
Location	Empower Field at Mile High, Denver, Colorado
TV	CBS
Streaming	Paramount+, NFL+ (mobile)

What time is Broncos vs Bills?

The Denver Broncos take on the Buffalo Bills on Saturday, January 17, 2026 at 4:30 p.m. ET.

Where is the Broncos vs Bills game being played?

This Divisional round matchup between the Broncos and the Bills will take place at Empower Field at Mile High, Denver, Colorado.

How can I watch Broncos vs Bills on TV and live stream?

The Broncos vs Bills game will be telecast on CBS with live streaming available on platforms such as FuboTV, Paramount+, YouTube TV (with NFL Sunday Ticket), and on NFL+ (mobiles and tablets).

The above odds are sourced from FanDuel. Use FanDuel to ace your betting game in all sports!

Mandatory Credit: Imagn Images [Corey Perrine/Florida Times-Union]

Devavrat Kulkarni

nfl

I am a content writer for the NFL team, and joined The Playoffs after working with Sportskeeda and NFL Analysis as an NFL writer. After starting my professional career as a French-to-English translator, working as a content writer is a new adventure for me. I started out in the sports media field for two main reasons: my love for sports in general, especially the NFL, NBA, and Tennis, as well as my passion for writing. The best part of this job is that I get to write a variety of pieces with the freedom to explore content from various angles. It also enables me to stay up to date with the sporting world, which otherwise can be difficult to do in the day-to-day grind. In a world full of chaos, sports unite and entertain like nothing else!