Cincinnati Bengals vs Detroit Lions Preview, Predictions, and Betting Odds – Week 5 NFL 2025-26 Season

The Cincinnati Bengals will host the Detroit Lions for Week 5’s Sunday action. The Cincinnati Bengals, after starting out their season 2-0, are now 2-2 for the season, ever since Joe Burrow went down with his turf toe injury. Things are looking bleak for the Bengals, as after each game, their chance to make the playoffs is going down further. Meanwhile, the Lions are red hot to start their season, and even with the loss of their coordinators, they have continued to dominate in the NFC.

Happy birthday to Mike Gesicki and T.J. Slaton 🎉 pic.twitter.com/j4pyH15mbX
— Cincinnati Bengals (@Bengals) October 3, 2025

Recommended Bets	FanDuel	BetMGM
Jahmyr Gibbs anytime TD scorer	-230	-220
Total TDs over 5.5	-134	-120
Jahmry Gibbs Over 15.5 rushing attempts	-108	-130

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Rationale and Analysis

After going scoreless in the first game against the Packers, Jahmyr Gibbs has looked to be unstoppable so far, scoring 4 touchdowns in 4 games. The Lions are utilizing him a lot this season, and is already at 58 rushing attempts for the season. Looking at the Bengals’ rush defense (26th) and scoring defense (27th), it’s easy to bet on Gibbs scoring at least one TD.

The game between the Bengals and the Lions is bound to go over 5.5 TDs, due to each team’s defense. While the Lions are a force to deal with on the offensive end, their defense still requires some work, and could be inconsistent at times. Meanwhile, the Bengals have been horrible defensively and are one of the worst teams at moment on that side of the field. Looking at both teams’ defensive lapses, we predict that the TDs 5.5 is possible.

In the last two games against the Baltimore Ravens and the Cleveland Browns, Jahmyr Gibbs has 22 and 15 rush attempts respectively. Going into this lopsided matchup, we expect the Lions to run with the football a lot more than pass, making the over 15.5 rush attempts bet safe.

Bengals vs Lions Preview

The Cincinnati Bengals are set to take on the Detroit Lions for this Week 5 matchup. The Bengals, despite their 2-2 record, are on pace to be one of the worst teams this season, looking at their last two games without Joe Burrow. The Bengals suffered their worst franchise loss against the Vikings, and lost 3-28 against the Broncos.

On the other hand, the Lions have not slowed down this season. Jahmyr Gibbs, David Montgomery, Jared Goff, Aiden Hutchinson, and Amon Ra-St. Brown have all been playing tremendously, and if the Lions improve on their defense a little more than they are, they are looking like a serious threat as a Super Bowl contender.

Happy Caturday before the clash of the big cats pic.twitter.com/BITUkhJpBn
— Detroit Lions (@Lions) October 4, 2025

Bengals vs Lions Prediction

We expect the Lions to blow out the Bengals in this Week 5, AFC vs NFC clash. Bengals seriously need a quarterback, and Jake Browning, their current starting QB, has not been helping the team with all the turnovers he’s caused. The Lions are one of the top teams in the NFL yet again this season, and have no reason to slow down against the Bengals.

Prediction: Lions win the game 35-10

Bengals vs Lions Betting Odds

Here are some of the best player bets and over/under for the Cincinnati Bengals and the Detroit Lions, according to BetMGM

Cincinnati Bengals Over/Under Odds

Below listed are over/under odds for the Cincinnati Bengals, according to BetMGM

Over/Under Bets	Over	Under
Jake Browning passing yards	223.5 (-115)	223.5 (-115)
Ja’Marr Chase receiving yards	64.5 (-115)	64.5 (-115)
Chase Brown rushing yards	49.5 (-118)	49.5 (-110)

Cincinnati Bengals Best Player Bets

Here are some of the best player bets for the Cincinnati Bengals, according to BetMGM

Chase Brown under 14.5 rushing attempts: -125
Jake Browning to thrown over 0.5 INTs: -175
Jake Browning under 1.5 passing TDs: -210

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Detroit Lions Over/Under Odds

Below listed are over/under for the Detroit Lions, according to BetMGM

Over/Under Bets	Over	Under
Jared Goff passing yards	245.5 (-115)	245.5 (-115)
Amon-Ra St. Brown receiving yards	72.5 (-115)	72.5 (-115)
Jahmyr Gibbs	78.5 (-115)	78.5 (-115)

Detroit Lions Best Player Bets

Here are some of the best player bets for the Detroit Lions, according to BetMGM

Jared Goff over 1.5 passing TDs: -185
Jared Goff under 0.5 INTs thrown: -185
Jahmyr Gibbs anytime TD scorer: -220
David Montgomery anytime TD scorer: -185

Bengals vs Lions Spread and Betting Odds

Looking at the spread and the moneyline, the Lions are the overwhelming favorites to win the matchup against the Bengals, according to BetMGM

Teams	Spread	Total Points	Moneyline
Lions	-10.5 (-105)	49.5 (-110)	-600
Bengals	+10.5 (-115)	49.5 (-110)	+425

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FAQs

Who is favored to win between the Bengals and the Lions?
The Lions are the 10.5-point favorites to win the game against the Bengals.

What is the over/under total for the game?
The over/under for total points is set at 49.5.

What is the predicted score for the Bengals vs Lions game?
The Predicted score is 35-10 in favor of the Lions.

Eric Divakaran

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I cover the National Football League and things cannot get better than that. I always dreamed to play football or basketball professionally since I’m built like a Running Back. But now that I can’t, since I’m technically in the “Unc” age, I thought why not pick a career in sports industry? So here I am, doing what I love, and hoping that the Commanders win the Super Bowl. I give love to players when it’s due, but can be critical about their performances at the same time. Enough about me, now let my articles do all the talking.