Mandatory Credit: Dan Hamilton-Imagn Images

Holger Rune vs. Alexandre Muller Head-to-Head, Prediction, and Betting Odds for ATP National Bank Open 2025 Round of 32

Alexandre Muller had a breakthrough year and stormed into the top 50.

Mandatory Credit: Dan Hamilton-Imagn Images

No. 5 seed Holger Rune will be taking on 29th-seed Alexandre Muller in the round of 32 in the 2025 National Bank Open. Rune outclassed Giovanni Mpetshi Perricard in straight sets to kick off his hard-court campaign, while Alexandre Muller came from one-set down to beat Miomir Kecmanovic to reach the second round.

Holger Rune entered the National Bank Open with a first-round exit in the Wimbledon. The Danish ace had a late withdrawal in Washington so his actual North-American hard-court swing starts with National Bank Open. The 22-year-old had a runner-up finish in the Indian Wells this year. Overall, he had a tough season with a 23-14 record.

Holger Rune opens up on working with Andre Agassi 🎾… pic.twitter.com/tBMAD2YePA
— FirstSportz Tennis (@FS_Tennis1) July 31, 2025

Alexandre Muller had a breakthrough year and stormed into the top 50. He is just one win away to have his best run in the ATP Maters. However, the Frenchman posted a 0-4 record against the top-10 players on hard court which is a big concern. He won just one game against Moutet in the Citi DC Open last week. Muller faced Novak Djokovic in the first-round of the Wimbledon and managed to win one set.

Holger Rune vs. Alexandre Muller Head to Head Record

Holger Rune holds the 1-0 ATP H2H record against Alexandre Muller. Both players met in the Biella 7 quarterfinals four years back where the Danish ace clinched the game in straight sets.

Year	Event	Round	Winner	Score
2021	Biella 7	Quarterfinal	Holger Rune	6-4, 6-4

Holger Rune vs. Alexandre Muller Career Comparison

Holger Rune	Category	Alexandre Muller
9	Current Ranking	41
162–99	Career W-L	45–56
23-14	YTD W-L	21-19
5	Career Titles	1
0	Grand Slams	0
1	YTD Titles	0

Holger Rune vs. Alexandre Muller 2025 National Bank Open Prediction

Holger Rune takes the edge in comparison with Muller when it comes to striking the balance between power and variety. Both players will look to play a patient game over three sets. Upset is unlikely to happen in this tie as Rune’s heavy ball will be tested by Muller’s attacking returns.

Prediction: Rune in straight sets.

Holger Rune vs. Alexandre Muller 2025 National Bank Open Betting Odds

Holger Rune is clear favourite in the R-32 matchup against underdog Muller. According to the implied probability on the money line, the youngster holds an advantageous 80% chance of victory. Here are all the relevant odds for the Washington war (as per BetMGM):

Holger Rune Win: 3/10
Alexandre Muller Win: 5/2

Total Games By Rune >12.5: 5/6
Total Games By Muller <11.5: 10/13
Muller +3.5 (Game Handicap): 19/20
Rune to Win 2-1: 13/6
Muller to Win At Least 1 Set (Yes): 17/20

(According to BetMGM: BetMGM offers exclusive promo codes, bonus deals and accurate odds for users upon signing up. Use BetMGM to ace your betting game in all sports!)

Mandatory Credit: Dan Hamilton-Imagn Images

Alexandre Muller

Holger Rune

National Bank Open

Gulshan Sharma

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A native of Jaipur, Rajasthan, journalist, and a complete soccer and basketball fan, he found the huge interest with basketball by watching videos of Allen Iverson and Tony Parker, but fell head over heels in love with the sport during the Warriors’ championship era (2015-2018). A sports game addict since his late PS1, he’s also passionate about the Eagles, Inter Miami and the Fever. He’s fortunate to have seen all his favorite teams win championships. He also has a special love for cricket and football (soccer), where he is a fan of Royal Challengers Bangalore and Barcelona.