New Orleans Pelicans vs Cleveland Cavaliers Prediction, Picks and Odds for Saturday, March 21

The New Orleans Pelicans will lock horns with the Cleveland Cavaliers on Saturday, March 21 at Smoothie Kings Center in New Orleans. The Pelicans have occupied themselves the 11th spot in the Western Conference, and will enter the fixture on the back of a three-game winning streak. The Cleveland Cavaliers, on the other hand, are seeded at the fourth spot in the East, and they are coming off two back-to-back wins in their recent fixtures.

The Cavaliers are 4.5-point favorites with moneyline at -180 and total around 234.5 points. These NBA odds today suggest that the Cavaliers are highly likely to clinch a win from the Pelicans. We have got our Best Bet, a same-game parlay, and a few player props for today’s game.

Here’s how we are betting for the New Orleans Pelicans vs Cleveland Cavaliers tonight.

Best Bet for New Orleans Pelicans vs Cleveland Cavaliers

Best Bet: Cleveland Cavaliers -4.5 (-110)

Book: Best price at FanDuel

Our best bet for New Orleans Pelicans vs Cleveland Cavaliers is Cavaliers -4.5 (-110) against the spread.

The New Orleans Pelicans have maintained a 16-21 record at home, whereas their counterparts have been dominating on the court with a 21-14 win-loss record. Talking about their on-court stats, the Cavaliers have been seeded fifth in the stats offensively while their defense has kept them in the 14th spot. On the other hand, the Pelicans are amongst the bottom ten teams in both offense and defense.

The spread at Cavaliers -4.5 fits the visitors well considering their elite offense and better defense. They generally cover when in such spots.

Keeping their offensive and defensive edges in mind, we are comfortably laying the Cleveland Cavaliers -4.5 (-110) as our Best Bet, and expect the guests to cover the number tonight comfortably.

Same-Game Parlay Picks for New Orleans Pelicans vs Cleveland Cavaliers

3-Leg SGP (Safer)

Leg 1: Cleveland Cavaliers -10.5 (alternate spread)
Leg 2: Donovan Mitchell Over 26.5 points
Leg 3: James Harden Over 20.5 points

Combined odds: +751

We have built this same-game parlay around the New Orleans Pelicans to record a significant win over the Pelicans. Mitchell has been the force behind the Cavaliers’ offense, and he is expected to drop another dominating performance against the Pelicans. Harden has been making key contributions, and we see another similar kind of game from him.

These legs are correlated considering if the Cavaliers are taking control of the game right from the beginning, their players will get ample scoring opportunities. This way, they will end up with more volume. Hence, this is our safer SGP option.

New Orleans Pelicans vs Cleveland Cavaliers Odds and Top Player Props

Here are the latest New Orleans Pelicans vs Cleveland Cavaliers odds from top sportsbooks. Shop around for the best NBA odds before locking in your bets.

Team	Spread	Moneyline	Total
Cleveland Cavaliers	-4.5 (-110)	-180	O 234.5 (-110)
New Orleans Pelicans	+4.5 (-110)	+152	U 234.5 (-110)

Odds from FanDuel, updated on Saturday, March 21, 2026 at 2:39 am EDT. Lines may move throughout the day.

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New Orleans Pelicans vs Cleveland Cavaliers Top Player Prop Odds

Given how prop-heavy NBA betting is, we are also eyeing these player props for New Orleans Pelicans vs Cleveland Cavaliers.

Evan Mobley Over 20.5 points (-104)
Zion Williamson Over 19.5 points (-108)
Dejounte Murray Over 16.5 points (-130)

These legs fit well into usage and volume. Mobley has been a key contributor for the Cavaliers, and he could make use of the weaker offense and defense of the Pelicans to add some points to the scoresheet. Zion Williamson and Dejounte Murray would want to take advantage of playing at home, and get some points against the visitors.

Trends to Know for New Orleans Pelicans vs Cleveland Cavaliers

Here are a few betting trends to keep in mind for New Orleans Pelicans vs Cleveland Cavaliers.

The New Orleans Pelicans have been 8-2-0 ATS in their last ten games.
The Cleveland Cavaliers have been 15-20-0 ATS on the road this NBA season.
Over has hit the Cavaliers in 34 of their 70 games thus far.

Latest Injuries and NBA Injury Report for New Orleans Pelicans vs Cleveland Cavaliers

Before betting this game, it’s important to check the NBA injury report, as late scratches and minutes limits can swing spreads and totals in a hurry.

Team	Player	Injury	Status
New Orleans Pelicans	Bryce McGowens	Toe	Out
Cleveland Cavaliers	Jaylon Tyson	Toe	Questionable
Cleveland Cavaliers	Donovan Mitchell	Eye	Questionable
Cleveland Cavaliers	Olivier Sarr	Calf	Questionable
Cleveland Cavaliers	Jarrett Allen	Knee	Out
Cleveland Cavaliers	Craig Porter Jr.	Groin	Out
Cleveland Cavaliers	Tyrese Proctor	Quadriceps	Out

In the NBA, late injury news and minutes restrictions have a huge impact on spreads and totals, so re-check the injury report and final inactives about an hour before tip-off.

What time is New Orleans Pelicans vs Cleveland Cavaliers on Saturday?

The New Orleans Pelicans vs Cleveland Cavaliers is scheduled to tip off at 7:00 pm EDT on March 21.

Where will New Orleans Pelicans vs Cleveland Cavaliers be played?

The New Orleans Pelicans vs Cleveland Cavaliers will be played at Smoothie King Center, New Orleans, LA.

Where can I watch New Orleans Pelicans vs Cleveland Cavaliers on TV and live stream?

The New Orleans Pelicans vs Cleveland Cavaliers will be available on FanDuel SN OH. The live stream, on the other hand, will be accessible on Fubo and NBA League Pass.

Detail	Information
Date	Saturday, March 21, 2026
Time	7:00 pm EDT
Venue	Smoothie King Center, New Orleans, LA
TV / Live Stream	FanDuel SN OH, NBA League Pass, Fubo