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NFL Week 17 Picks, Spreads, and Predictions – Lines, Spreads, and Betting Odds for Every Team ahead of 2025-26 Season Week 17

Devavrat Kulkarni

With Week 16 of the 2025-26 NFL season in the books, we are left with only two more weeks of regular-season football. After the Colts lost on Monday Night Football (MNF), three more teams, the Bills, Jaguars, and Chargers, booked their spots in the playoffs. 

Now, it’s time to turn our attention to Week 17 as more teams look to punch their way to the postseason. Games for the Colts and Ravens from the AFC and the Lions, Buccaneers, and Panthers from the NFC will be crucial for their chances at the postseason.

NFL Week 17 Team Picks

Here are some of the picks worth considering ahead of the full slate of Week 17 games as per the odds on FanDuel.

  • Seattle Seahawks win against the Carolina Panthers: -360
  • Tampa Bay Buccaneers win and cover the spread (-5.5) against the Miami Dolphins: -105
  • Jacksonville Jaguars win against the Indianapolis Colts: -330
  • San Francisco 49ers win against the Chicago Bears: -176

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The Seahawks are currently on a high after their superb come-from-behind win over the Rams last week. While the Panthers are also playing well and coming off a win over the Bucs last week, Seattle has the better roster on both sides of the ball. 

Tampa Bay is currently a game behind Carolina for the top spot in the NFC South. A win against the Dolphins is crucial for their chances to regain the advantage. The Buccaneers’ offense is nearly back to its best after a few weeks when they lacked any punch. Miami’s season is over, and the Dolphins might hand their backups some additional playing time with regard to the future.  

The Jaguars and Colts are trending in opposite directions. Jacksonville has clinched a spot in the playoffs, but winning the final two games could land them the number one seed in the AFC. The Colts’ season has turned on its head, and even though Philip Rivers kept them in the Monday Night Football game against the 49ers yesterday for so long, this team doesn’t have a capable defense. 

San Francisco has struggled with several injuries to key players, yet it finds ways to win games. The 49ers were once again at their best on Monday against the Colts, and even though the Bears are currently a much superior team than the Colts, San Francisco’s current form of 5 wins in a row provides them a slight advantage, as does their home field. 

NFL Week 17 Spreads

Heading into Week 17, the Denver Broncos are 12.5-point favorites over the Kansas City Chiefs. Similarly, in another divisional clash, the New England Patriots are also 12.5-point favorites over the New York Jets. The Los Angeles Rams are 8.5-point favorites in their game against the Atlanta Falcons.

Moneylines and Betting Odds for Week 17

Coming to the lines, the Patriots are favored over the Jets by -1200 odds, whereas the Broncos are -820 against the Chiefs. As for the Rams, they are favored by -520 over the Falcons. 

Let us now take a look at the betting odds as per FanDuel for all week 17 matchups, along with the predictions.

Dallas Cowboys (6-8-1) vs Washington Commanders (4-11)

SpreadMoneylineTotal Points
Dallas Cowboys-6.5 (-118)-320O 50.5 (-106)
Washington Commanders+6.5 (-104)+260U 50.5 (-114)

Prediction: Dallas Cowboys to win.

Detroit Lions (8-7) vs Minnesota Vikings (7-8)

SpreadMoneylineTotal Points
Detroit Lions-5.5 (-118)-275O 44.5 (-110)
Minnesota Vikings+5.5 (-104)+225U 44.5 (-110)

Prediction: Detroit Lions to win.

Denver Broncos (12-3) vs Kansas City Chiefs (6-9)

SpreadMoneylineTotal Points
Denver Broncos-12.5 (-115)-820O 36.5 (-110)
Kansas City Chiefs+12.5 (-105)+570U 36.5 (-110)

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Prediction: Denver Broncos to win.

Houston Texans (10-5) vs Los Angeles Chargers (11-4)

SpreadMoneylineTotal Points
Houston Texans+1.5 (-105)+110O 39.5 (-115)
Los Angeles Chargers-1.5 (-115)-130U 39.5 (-105)

Prediction: Houston Texans to win.

If you’re looking for a complete guide to the best NFL betting sites, we’ve got you covered 

Baltimore Ravens (7-8) vs Green Bay Packers (9-5-1)

SpreadMoneylineTotal Points
Baltimore Ravens+2.5 (-115)+116O 40.5 (-118)
Green Bay Packers-2.5 (-105)-136U 40.5 (-104)

Prediction: Green Bay Packers to win.

Seattle Seahawks (12-3) vs Carolina Panthers (8-7)

SpreadMoneylineTotal Points
Seattle Seahawks-7.5 (-102)-360O 42.5 (-112)
Carolina Panthers+7.5 (-120)+290U 42.5 (-108)

Prediction: Seattle Seahawks to win.

Arizona Cardinals (3-12) vs Cincinnati Bengals (5-10)

SpreadMoneylineTotal Points
Arizona Cardinals+7 (-110)+295O 53.5 (-110)
Cincinnati Bengals-7 (-110)-370U 53.5 (-110)

Prediction: Arizona Cardinals to win.

Tampa Bay Buccaneers (7-8) vs Miami Dolphins (6-9)

SpreadMoneylineTotal Points
Tampa Bay Buccaneers-5.5 (-105)-240O 45.5 (-110)
Miami Dolphins+5.5 (-115)+198U 45.5 (-110)

Prediction: Tampa Bay Buccaneers to win.

Jacksonville Jaguars (11-4) vs Indianapolis Colts (8-7)

SpreadMoneylineTotal Points
Jacksonville Jaguars-6.5 (-118)-330O 47.5 (-106)
Indianapolis Colts+6.5 (-104)+265U 47.5 (-114)

Prediction: Jacksonville Jaguars to win.

New England Patriots (12-3) vs New York Jets (3-12)

SpreadMoneylineTotal Points
New England Patriots-12.5 (-115)-1200O 42.5 (-114)
New York Jets+12.5 (-105)+750U 42.5 (-106)

Prediction: New England Patriots to win.

New Orleans Saints (5-10) vs Tennessee Titans (3-12)

SpreadMoneylineTotal Points
New Orleans Saints-3 (-104)-158O 38.5 (-118)
Tennessee Titans+3 (-118)+134U 38.5 (-104)

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Prediction: New Orleans Saints to win.

Pittsburgh Steelers (9-6) vs Cleveland Browns (3-12)

SpreadMoneylineTotal Points
Pittsburgh Steelers-3.5 (-120)-210O 33.5 (-120)
Cleveland Browns+3.5 (-102)+176U 33.5 (-102)

Prediction: Pittsburgh Steelers to win.

New York Giants (12-3) vs Las Vegas Raiders (6-9)

SpreadMoneylineTotal Points
New York Giants+1.5 (-118)-102O 41.5 (-110)
Las Vegas Raiders-1.5 (-104)-116U 41.5 (-110)

Prediction: Las Vegas Raiders to win.

Philadelphia Eagles (10-5) vs Buffalo Bills (11-4)

SpreadMoneylineTotal Points
Philadelphia Eagles+2.5 (-110)+118O 44.5 (+100)
Buffalo Bills-2.5 (-110)-138U 44.5 (-122)

Prediction: Buffalo Bills to win.

Chicago Bears (11-4) vs San Francisco 49ers (11-4)

SpreadMoneylineTotal Points
Chicago Bears+3 (-105)+148O 51.5 (-105)
San Francisco 49ers-3 (-115)-176U 51.5 (-115)

Prediction: San Francisco 49ers to win.

Los Angeles Rams (12-3) vs Atlanta Falcons (6-9)

SpreadMoneylineTotal Points
Los Angeles Rams-8.5 (-104)-520O 49.5 (-112)
Atlanta Falcons+8.5 (-118)+390U 49.5 (-108)

Prediction: Los Angeles Rams to win.

All of the above odds are sourced from FanDuel. Use FanDuel to ace your betting game in all sports!

Mandatory Credit: James Lang-Imagn Images

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I am a content writer for the NFL team, and joined The Playoffs after working with Sportskeeda and NFL Analysis as an NFL writer. After starting my professional career as a French-to-English translator, working as a content writer is a new adventure for me. I started out in the sports media field for two main reasons: my love for sports in general, especially the NFL, NBA, and Tennis, as well as my passion for writing. The best part of this job is that I get to write a variety of pieces with the freedom to explore content from various angles. It also enables me to stay up to date with the sporting world, which otherwise can be difficult to do in the day-to-day grind. In a world full of chaos, sports unite and entertain like nothing else!

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