Image Credit - Corey Perrine/Florida Times-Union / USA TODAY NETWORK

NFL Week 4 – 49ers vs. Jaguars Injury Report: Major Updates on Brock Purdy, Jauan Jennings, and Ricky Pearsall as San Francisco Faces Key Depth Questions

Image Credit - Corey Perrine/Florida Times-Union / USA TODAY NETWORK

The San Francisco 49ers enter Week 4 unbeaten at 3-0, leaning on a defense that has kept opponents in check and an offense that’s been efficient through the air. They’ve been moving the ball well, ranking near the top of the league in passing yards, but haven’t always turned that production into points.

Christian McCaffrey continues to be the centerpiece, while young receivers are stepping up to give San Francisco balance. At home, they’ll look to dictate tempo early and avoid the slow starts that have kept games closer than expected.

Christian McCaffrey is the 1st player with 50+ carries and 25+ catches through the 1st 3 weeks of a season since Thurman Thomas in 1991. pic.twitter.com/qc8eWWtwH5
— NFL Stats (@NFL_Stats) September 23, 2025

Jacksonville Jaguars, at 2-1, has built its success on a defense that thrives on takeaways and a ground game that controls possession. Travis Etienne has been the steady force, while Trevor Lawrence has shown flashes but still needs to cut down on turnovers.

The Jaguars’ ability to win the turnover battle has been their edge, and they’ll need it again against a 49ers team that can pile up yards quickly. History favors San Francisco in this matchup, but Jacksonville’s defensive opportunism and strong run game suggest this could be a tighter contest than past meetings.

Jacksonville Jaguars Injury Report for Game Against San Francisco 49ers

PLAYER NAME	POS	STATUS	UPDATE
Yasir Abdullah	LB	Out	Abdullah (hamstring) has been downgraded and ruled out ahead of Sunday’s matchup against the 49ers.
Wyatt Milum	G	Out	Milum (knee) has been ruled out for Sunday’s contest against the 49ers.
Dyami Brown	WR	Questionable	Brown (shoulder) is listed as questionable for Sunday’s game against the 49ers after practicing in a limited fashion Thursday and Friday.
Jalen McLeod	LB	Injured Reserve	McLeod (lower body) was placed on injured reserve with a designation to return Tuesday.
Caleb Ransaw	CB	Injured Reserve	Jacksonville placed Ransaw (lower body) on its injured reserve list Tuesday.
Joshua Cephus	WR	Injured Reserve	Cephus (undisclosed) reverted to injured reserve with the Jaguars on Thursday.
Cooper Hodges	OT	Out	Hodges (knee) cleared waivers and reverted to Jacksonville’s PUP list Thursday.

San Francisco 49ers Injury Report for Game Against Jacksonville Jaguars

PLAYER NAME	POS	STATUS	UPDATE
Jauan Jennings	WR	Questionable	Jennings (ankle/shoulder) is expected to suit up for Sunday’s game versus the Jaguars.
Ricky Pearsall	WR	Questionable	Pearsall (knee) is slated to play Sunday versus the Jaguars.
CJ West	DT	Out	West (thumb) has been ruled out for Sunday’s contest against Jacksonville.
Renardo Green	CB	Questionable	Green (neck) is questionable to play Sunday against the Jaguars.
Jordan Watkins	WR	Out	Watkins (calf) has been ruled out for Sunday’s contest against the Jaguars
Nick Bosa	DE	Injured Reserve	Bosa (knee) underwent surgery to address his torn ACL on Friday.
Mac Jones	QB	Questionable	Jones (knee) is listed as questionable for Sunday’s contest versus the Jaguars.
Brandon Aiyuk	WR	Out	Aiyuk (knee, PUP) is not close to returning.
Connor Colby	G	Questionable	Colby is listed as questionable.
Spencer Burford	OT	Injured Reserve	Burford (knee) was placed on injured reserve Saturday.
Ben Bartch	G	Injured Reserve	Bartch (ankle) was placed on injured reserve Wednesday.
George Kittle	TE	Injured Reserve	The 49ers placed Kittle (hamstring) on injured reserve Tuesday.
Jakob Robinson	CB	Injured Reserve	Robinson (forearm) was placed on injured reserve Tuesday.
Jacob Cowing	WR	Injured Reserve	The 49ers placed Cowing (hamstring) on injured reserve Wednesday.
Kevin Givens	DT	Injured Reserve	Givens (pectoral) was placed on injured reserve Tuesday.
Malik Mustapha	S	Out	Mustapha (knee) was placed on the reserve/PUP list Tuesday.
Kurtis Rourke	QB	Out	Rourke (knee) was placed on the reserve/non-football injury list Tuesday.
Patrick Taylor Jr.	RB	Injured Reserve	Taylor will undergo season-ending surgery to repair a fracture in his shoulder.
Tarron Jackson	DE	Injured Reserve	Jackson (undisclosed) was discharged from the hospital and returned to the 49ers’ training camp Monday.
Trent Taylor	WR	Injured Reserve	The 49ers placed Taylor (undisclosed) on injured reserve Tuesday.