Jan 21, 2024; Melbourne, Victoria, Australia; Amanda Anisimova of the United States shakes hands with Arnya Sabalenka of Belarus after losing to her in in the forth round of the womens singles at the Australian Open 2024.

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Aryna Sabalenka vs. Amanda Anisimova Head-to-Head, Prediction and Betting Odds for US Open 2025 Final

Sabalenka will face an American in the final for a third consecutive year.

World No. 1 Aryna Sabalenka will be looking to defend her championship, as she takes on home favorite Amanda Anisimova in the US Open 2025 final on Saturday. The American defeated Sabalenka at the recently concluded Wimbledon Championships, and another win will help secure her first major trophy. However, the 27-year-old Belarusian will not make it easy for her. As two of the most fierce ball strikers in the women’s division take center stage, let’s take a look at the preview and best odds for this clash – via BetMGM.

Aryna Sabalenka vs Amanda Anisimova Match Preview

Aryna Sabalenka will look to repeat.

Amanda Anisimova will look to win her home Grand Slam.

Here we go. pic.twitter.com/h6UHPrZ7gJ
— US Open Tennis (@usopen) September 5, 2025

Having dropped just one set across six matches, Aryna Sabalenka will enter the final with relatively fresh legs. The top seed has reached every hard court Grand Slam final since the end of 2022, and will be desperate to hold onto her crown in New York. A three-time major champion, Sabalenka has already reached the finals of the Australian Open and Roland Garros this year – losing both. She has won three trophies in 2025, and holds a record of 56-10 thus far. Her wins at Flushing Meadows have come against Masarova, Kudermetova, Fernandez, Bucsa, Vondrousova (walkover) and Pegula.

Aryna Sabalenka becomes the first woman to reach 3 consecutive U.S. Open finals since Serena Williams.

Serena Williams – 2014.

Aryna Sabalenka – 2025.

Keeping iconic company. 🐅 pic.twitter.com/66pFpzOcSw
— The Tennis Letter (@TheTennisLetter) September 5, 2025

After a heartbreaking loss in the Wimbledon final, Amanda Anisimova returns to a Grand Slam summit clash yet again. She managed to gain sweet revenge over Iga Swiatek along the way, meaning that the 24-year-old has the opportunity to capture her maiden major title. Currently ranked No. 9 in the world, Anisimova has made a solitary championship run – at Doha – in 2025. She is winning close to 73% points on first serve at this event, and has a YTD W-L record of 39-15. She has beaten Birrell, Joint, Cristian, Haddad Maia, Swiatek and Osaka en route to Saturday’s contest.

Amanda Anisimova becomes the youngest woman to reach the Wimbledon final & the US Open final in the same season since Serena and Venus Williams in 2002.

24 years old.

Unbelievable talent, doing unbelievable things.

🇺🇸❤️ pic.twitter.com/cfQoJAvcp7
— The Tennis Letter (@TheTennisLetter) September 5, 2025

Aryna Sabalenka vs Amanda Anisimova Head to Head Record

Anisimova leads the head-to-head against Sabalenka by 6-3.

The two players first met at the 2019 Australian Open, where Anisimova brushed aside the then 11th seed Sabalenka. She went on to win the next three duels against her Belarusian counterpart as well, before the tigress roared back. In 2025, they will be facing one another in the third consecutive Grand Slam at Flushing Meadows.

Event	Round	Winner	Score
2025 Wimbledon	Semifinal	Amanda Anisimova	6-4 4-6 6-4
2025 Roland Garros	Round of 16	Aryna Sabalenka	7-5 6-3
2024 Toronto	Quarterfinal	Amanda Anisimova	6-4 6-2
2024 Australian Open	Round of 16	Aryna Sabalenka	6-3 6-2
2022 Rome	Quarterfinal	Aryna Sabalenka	4-6 6-3 6-2
2022 Madrid	Round of 64	Amanda Anisimova	6-2 3-6 6-4
2022 Charleston	Round of 16	Amanda Anisimova	3-6 6-4 6-3
2019 Roland Garros	Round of 64	Amanda Anisimova	6-4 6-2
2019 Australian Open	Round of 32	Amanda Anisimova	6-3 6-2

Aryna Sabalenka vs Amanda Anisimova Career Comparison

Aryna Sabalenka	Category	Amanda Anisimova
1	Current Ranking	9
472-198	Career W-L Record	200-113
56-10	YTD W-L Record	39-15
20	Career Titles	3
3	YTD Titles	1
3	Grand Slams	0

Aryna Sabalenka vs Amanda Anisimova US Open 2025 Prediction

Historically speaking, Anisimova holds a stylistic and mental edge over Sabalenka. The American enjoys using the pace of opponents, and knows how to emerge on top when it comes to flat baseline exchanges. This is why the World No. 1 has primarily been able to trouble Anisimova on clay – where the bounce is high and court speed is much slower. However, Sabalenka has considerably improved her net game and serve plus one tactic. She is a big match player, and will be determined to avoid another loss in the final of a Grand Slam.

Prediction: Aryna Sabalenka in three sets.

Aryna Sabalenka vs Amanda Anisimova US Open 2025 Betting Odds

Sabalenka is the favorite and Anisimova is the underdog for the US Open 2025 final. According to the implied probability on the money line, the top seed has a 62% chance of lifting the trophy yet again. Here are the odds (as per BetMGM):

Aryna Sabalenka Win: 1/2
Amanda Anisimova Win: 7/4

Total Games <21.5: 19/20
Anisimova +3.5 (Game Handicap): 17/20
Sabalenka -1.5 (Set Handicap): 5/4
Total Sets <2.5: 4/7
Total Number of Tiebreaks <0.5: 7/20
Anisimova to Win At Least 1 Set (Yes): 16/25
Total Minutes >110.5: 22/25
Total Aces >8.5: 16/25

(According to BetMGM: BetMGM offers exclusive promo codes, bonus deals and accurate odds for users upon signing up. Use BetMGM to ace your betting game in all sports!)

(Image Credits: Mike Frey, Imagn Images)

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Sankalp Harikrishnan

A passionate sports fan through and through, I am currently pursuing my MA in Global Sports Journalism. I specialise in tennis and football writing at The Playoffs News, and I have prior experience working at EssentiallySports and Sportskeeda. Born and raised in Bengaluru, India, sport was my safe space right from my childhood. After trying my hand at multiple sports and representing my educational institutions in cricket, badminton and table tennis, I found sports media to be my calling.