0009 follows through on a shot during the first round match between Venus Williams (USA) and Jessica Bouzas Maneiro (ESP) in the Cincinnati Open at the Lindner Family Tennis Center in Mason, Ohio, on Thursday, Aug. 7, 2025. Bouzas Maneiro won in straight sets, 6-4, 6-4.

tennis

Venus Williams/Reilly Opelka vs. Karolina Muchova/Andrey Rublev Preview, Prediction and Betting Odds for US Open 2025 Round-1

Winners to face either Errani/Vavassori or Rybakina/Fritz in the QFs.

All-American star pairing of Venus Williams and Reilly Opelka will begin their 2025 US Open Mixed Doubles Championship campaign against Karolina Muchova and Andrey Rublev. It is set to be a first career meeting between the pairs, as the revamped mixed doubles event takes centre stage. Continue reading to find out all you need to know about the match-up, as well as BetMGM’s best odds.

Williams/Opelka vs Muchova/Rublev Match Preview

While the Venus Williams and Reilly Opelka pairing is fresh, they both have vast experience on tour. Williams, in particular, is a three-time Olympic gold medalist in doubles. She also won 14 doubles Grand Slams and two mixed doubles majors. Currently on her comeback trail, the 45-year-old is partnering a big-serving former Top-20 player in Opelka. Tied for being the tallest player on tour, the 27-year-old will dominate the baseline while Williams adds fire and accuracy to the team.

"We have a lot in common." 🥘🎨🧥

Reilly Opelka talks about his friendship with Venus Williams ahead of their US Open mixed doubles partnership. pic.twitter.com/vSLlWNNDxl
— Tennis Channel (@TennisChannel) August 10, 2025

As the tournament announced themselves, Karolina Muchova and Andrey Rublev “bring fire and ice to the 2025 US Open Mixed Doubles Championship.” The Czech-Russian duo happen to be some of the most fierce ball strikers on the singles circuit. While Rublev is a consistent name in the singles ATP Top-10, he also has four doubles championships and a mixed doubles Olympic gold medal. Meanwhile, Muchova is a US Open singles semifinalist over the past two years. She also finished fourth in women’s doubles at the 2024 Paris Olympics.

Williams/Opelka vs Muchova/Rublev Head to Head Record

The head-to-head record between Williams/Opelka and Muchova/Rublev is currently 0-0. They are two new pairs, and this is the first time they will stand across the net in mixed doubles.

Williams/Opelka vs Muchova/Rublev Doubles Career Comparison

Williams / Opelka	Category	Muchova / Rublev
580 / –	Current Ranking	547 / 391
1 / 89	Career-Best Ranking	222 / 44
–	YTD Titles	–
22 / 1	Career Titles	0 / 4
–	Grand Slams (As a Pair)	–

Williams/Opelka vs Muchova/Rublev US Open 2025 Prediction

When it comes to movement and court coverage, Muchova and Rublev have a clear advantage. However, the American crowd will be heavily backing the Williams/Opelka pairing. Moreover, the shortened format means that it will not be a real test of endurance like a regular doubles contest. If the Americans can keep the rally length short and sweet, they hold an advantage in this Round-1 encounter.

Prediction: Williams/Opelka in three sets.

Getting the work in! @Venuseswilliams and Reilly Opelka prep ahead of their match against Karolina Muchova and Andrey Rublev tomorrow. pic.twitter.com/UTyln8lO6s
— US Open Tennis (@usopen) August 18, 2025

Williams/Opelka vs Muchova/Rublev US Open 2025 Betting Odds

Karolina Muchova and Andrey Rublev have been named betting favourites ahead of their opening round battle vs Venus Williams and Reilly Opelka. According to the implied probability on the money line, the European young guns hold a 70% chance of advancing to the QF stage. Here are the match result odds (as per BetMGM):

Williams/Opelka Win: 13/8
Muchova/Rublev Win: 4/9

(According to BetMGM: BetMGM offers exclusive promo codes, bonus deals and accurate odds for users upon signing up. Use BetMGM to ace your betting game in all sports!)

(Image Credits: Sam Greene, Imagn Images)

Andrey Rublev

ATP

Karolina Muchova

Reilly Opelka

Tennis

US Open 2025

US Open Mixed Doubles

Venus Williams

WTA

Sankalp Harikrishnan

A passionate sports fan through and through, I am currently pursuing my MA in Global Sports Journalism. I specialise in tennis and football writing at The Playoffs News, and I have prior experience working at EssentiallySports and Sportskeeda. Born and raised in Bengaluru, India, sport was my safe space right from my childhood. After trying my hand at multiple sports and representing my educational institutions in cricket, badminton and table tennis, I found sports media to be my calling.