The new slate of games for the upcoming week in the NFL will feature the Los Angeles Rams taking on the San Francisco 49ers in the Thursday Night Football (TNF) showdown in week 5.
This NFC West clash featuring the Rams and the 49ers should be an exciting affair as both teams enter with a 3-1 record, and the winner will have the chance to top the division standings.
In week 4, the Rams took on the Colts and came through with a 27-20 win at home, whereas the 49ers lost at home 26-21 to the Jaguars. Turning our attention to the upcoming game, here are some same-game parlays and player props to take note of.
The Rams have 59 plays this season that have gained at least 10 yards, most in the NFL. The Rams already have seven touchdowns of 10+ yards, more than half of their total from last season. pic.twitter.com/OxXvPTs7jE
— Los Angeles Rams PR (@TheLARamsPR) September 30, 2025
Here are a couple of same-game parlays for the TNF game between the Los Angeles Rams and the San Francisco 49ers as per BetMGM.
Christian McCaffrey Anytime Touchdown Scorer (-125) + Matthew Stafford 250+ Yards (+123) + Puka Nacua 100+ Yards (+100)
Total Parlay Odds: +440
49ers’ running back Christian McCaffrey, when healthy, is a force to be reckoned with. Currently, he has played all 4 games this season and has punched his way to the endzone twice. Picking McCaffrey for an anytime touchdown seems like a good bet as the 49ers are struggling with numerous injuries in their wide receiver room.
Matthew Stafford has been throwing the ball very well to start the season. With passing yards of 245, 298, 196, and 375, he is a good bet to eclipse 250+ passing yards once again on Thursday.
Puka Nacua has been the leading pass-catcher and the number one go-to option for Rams quarterback Matthew Stafford. In four games, Nacua has crossed 100 receiving yards on 3 occasions.
Matthew Stafford 2+ TD passes (-157) + Christian McCaffrey rushing yards (+145) + Davante Adams Anytime Touchdown Scorer (+116)
Total Parlay Odds: +600
Matthew Stafford has a total of 8 passing touchdowns from the first four games, which means he is averaging 2 touchdowns per game. With his receivers healthy, there is a good chance he will continue the same trend on Thursday.
Christian McCaffrey should be the focus of the 49ers’ offense against the Rams, given all their struggles in the receiver room. So far, he has exceeded 50 rushing yards twice and 60 yards once, but he should see increased production in week 5.
Davante Adams already has 3 touchdowns in the first four games. Furthermore, all 3 touchdowns have come in 3 different games, suggesting he is a top-endzone target.
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California showcase this Thursday!
— San Francisco 49ers (@49ers) October 1, 2025
📺: https://t.co/D9NLBmWUND pic.twitter.com/S34oJsB9AE
Here are some best player props for this week’s game between the Rams and the 49ers as per BetMGM.
Kyren Williams has 303 rushing yards on the season and is averaging over 70 yards per game. In his last two games, Williams has rushed for 94 and 77 yards, respectively.
Davante Adams has played the role of second fiddle to Puka Nacua perfectly so far. Averaging over 50 yards receiving per game, Adams has emerged as a complementary piece of the receiving core. If Nacua is guarded closely by the 49ers, look for Stafford to go to his second read more than a few times.
As mentioned previously, the 49ers may run the ball more in this game. That means McCaffrey should receive plenty of touches in the backfield. McCaffrey is averaging around 17 carries per game, so this looks like a good bet.
49ers’ linebacker Fred Warner is known for his tackling ability. Through the first 4 games of the season, Warner has a total of 38 tackles, with the lowest being 8 in a game and the highest being 11.
The above odds are sourced from BetMGM. Use BetMGM to ace your betting game in all sports!
Mandatory Credit: Gary A. Vasquez-Imagn Images
nfl I am a content writer for the NFL team, and joined The Playoffs after working with Sportskeeda and NFL Analysis as an NFL writer. After starting my professional career as a French-to-English translator, working as a content writer is a new adventure for me. I started out in the sports media field for two main reasons: my love for sports in general, especially the NFL, NBA, and Tennis, as well as my passion for writing. The best part of this job is that I get to write a variety of pieces with the freedom to explore content from various angles. It also enables me to stay up to date with the sporting world, which otherwise can be difficult to do in the day-to-day grind. In a world full of chaos, sports unite and entertain like nothing else!
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