Texans vs Bills Predictions, Odds and Best Bets For Week 12 of the 2025-26 NFL Season

The Houston Texans are at home for this Week 12 prime-time clash against the Buffalo Bills on Thursday Night Football (TNF). This game will be a crucial one for the Texans, who are currently in the middle of a fight for a place in the playoffs with a 5-5 record.

The visiting Bills are having another great season, but are trailing the Patriots in the AFC East. A win for the Bills will be crucial in their pursuit of yet another divisional crown.

Game Details:

Time: 8:15 p.m. ET
Date: Thursday, November 20, 2025
Location: NRG Stadium, Houston, Texas
TV Channel: Amazon Prime Video
Streaming: Fubo, NFL+

Recommended bets and updated odds

Recommended Bets	FanDuel	BetMGM
Josh Allen Anytime Touchdown	-125	-121
Josh Allen 200+ Passing Yards	-230	-235
Nico Collins 70+ Receiving Yards	-140	-139

Analysis and Rationale

Josh Allen has stepped up his running game as of late. In his last game against the Buccaneers, Allen scored a total of 6 touchdowns, 3 of which came on the ground. Allen also has 7 rushing touchdowns from his last 4 games.

Josh Allen’s pass game continues to flourish once again. He has thrown for over 250 passing yards in his last three games, but the Texans have the number one defense in multiple categories, while their pass defense ranks third in the league, allowing just 171 yards per game.

Nico Collins has been on a tear for the Texans in the last three games, with over 70 receiving yards in each game. He remains the number one target for quarterback Davis Mills in a severely compromised wide receiver room.

.@BuffaloBills and @HoustonTexans square-off on #TNFonPrime 😤 pic.twitter.com/QcJ9RsYHnK
— NFL on Prime Video (@NFLonPrime) November 19, 2025

Texans vs Bills Prediction

The Texans are coming into this game without their starting quarterback, C.J. Stroud. Their offense has had its ups and downs this season, but the defense has been outstanding.

However, the Bills will pose a tough challenge, especially considering the form Josh Allen has been in. James Cook may have slowed down recently, but he is still a key part of the Bills’ offense. Buffalo comes into the game as the favorite and rightly so.

Prediction: Buffalo Bills to win.

Week 12 Texans vs Bills Betting Odds and Spread

The moneyline and spread show the Buffalo Bills are the favorites in this matchup against the Houston Texans. (Sourced from FanDuel).

	Moneyline	Spread	Total Points
Houston Texans	+235	+5.5 (+100)	O 43.5 (-108)
Buffalo Bills	-290	-5.5 (-122)	U 43.5 (-112)

FanDuel

High total bonus ceiling

Daily second-chance bet protection

No promo code required

$150

Welcome offer

Bet $5 & Get $150 in Bonus Bets

Click to reveal code

COPIED

F A N D U V I P

Claim now

New customers only. Must be 21+ in most jurisdictions, but 18+ in DC, KY, and WY. Offer is valid only in eligible regulated states/jurisdictions and not available in AR; void where prohibited. First online real-money wager only; cashed-out or bonus-funded bets are excluded.

Texans vs Bills Best Bets

Here are the over/under and best player bets for the Houston Texans and the Buffalo Bills, as per FanDuel.

Houston Texans Over/Under Odds

Below are some of the best over/under bets for the Houston Texans.

Over/ Under Bets	Over	Under
Davis Mills Pass Completions	19.5 (-122)	19.5 (-108)
Dalton Schultz Total Receptions	4.5 (+106)	4.5 (-140)
Woody Marks Rush Attempts	15.5 (-114)	15.5 (-114)

Houston Texans Best Player Bets

Below are some of the best player bets for the Houston Texans.

Davis Mills Over 1.5 Passing Touchdowns: +124
Nick Chubb 25+ Rushing Yards: +116
Nico Collins 70+ Receiving Yards: -140

If you’re looking for a complete guide to the best NFL betting sites, we’ve got you covered

Josh Allen has been named AFC Offensive Player of the Week.

This marks the 17th time No. 17 has earned the honor. pic.twitter.com/bZDfKBbStt
— Buffalo Bills PR (@BuffaloBillsPR) November 19, 2025

FanDuel

High total bonus ceiling

Daily second-chance bet protection

No promo code required

$150

Welcome offer

Bet $5 & Get $150 in Bonus Bets

Click to reveal code

COPIED

F A N D U V I P

Claim now

Buffalo Bills Over/Under Odds

Below are some of the best over/under bets for the Buffalo Bills.

Over/ Under Bets	Over	Under
Josh Allen Pass Completions	19.5 (+100)	19.5 (-132)
Dawson Knox Total Receptions	2.5 (+118)	2.5 (-158)
James Cook Rush Attempts	17.5 (-130)	17.5 (-102)

Buffalo Bills Best Player Bets

Below are some of the best player bets for the Buffalo Bills.

Josh Allen Most Passing Yards: -146
James Cook Most Rushing Yards: -135
Khalil Shakir 40+ Receiving Yards: -146

The above odds are sourced from FanDuel. Use FanDuel to ace your betting game in all sports!

FAQs

What is the over/under for total points for the Texans vs Bills game?

The over/under for total points in the Texans vs Bills game is set at 43.5.

What is the point spread for the Texans vs Bills game?

The Bills come into the game as 5.5-point favorites over the Texans.

What is the moneyline for the Texans vs Bills game?

The Bills are the favorites with a moneyline of -290, while the Texans are the underdogs at +235.

Mandatory Credit: Imagn Images

Devavrat Kulkarni

nfl

I am a content writer for the NFL team, and joined The Playoffs after working with Sportskeeda and NFL Analysis as an NFL writer. After starting my professional career as a French-to-English translator, working as a content writer is a new adventure for me. I started out in the sports media field for two main reasons: my love for sports in general, especially the NFL, NBA, and Tennis, as well as my passion for writing. The best part of this job is that I get to write a variety of pieces with the freedom to explore content from various angles. It also enables me to stay up to date with the sporting world, which otherwise can be difficult to do in the day-to-day grind. In a world full of chaos, sports unite and entertain like nothing else!