Mandatory Credit: Aaron Doster-Imagn Images

Taylor Townsend/Ben Shelton vs. Holger Rune/Amanda Anisimova Preview, Prediction and Betting Odds for US Open 2025 Mixed Doubles Round – 1

Mandatory Credit: Aaron Doster-Imagn Images

Wild card Taylor Townsend and Ben Shelton will face fourth seed Holger Rune and Amanda Anisimova in a blockbuster first-round mixed doubles clash at the 2025 US Open. This match brings together four players who have each enjoyed breakthrough seasons in their own right. With Townsend’s elite doubles run, Shelton’s singles rise into the ATP Top 10, Rune’s consistency at the highest level, and Anisimova’s summer surge.

Bringing the entertainment 🤩

Ben Shelton and Taylor Townsend are ready to bring the show to the US Open Mixed Doubles Championship! pic.twitter.com/DAeiTVwOc3
— US Open Tennis (@usopen) August 8, 2025

Taylor Townsend/Ben Shelton vs. Holger Rune/Amanda Anisimova Preview

Townsend enters as the most seasoned doubles player of the group, holding the World No. 1 ranking in a year that includes the Australian Open crown alongside Katerina Siniakova and further titles in Dubai and Washington. She has thrived across partnerships, with her sharp instincts making her a threat.

Teaming up with Shelton, one of the ATP’s fastest-rising stars, only adds to the intrigue. Shelton captured his maiden Masters 1000 trophy in Toronto, reached the semifinals in Melbourne, and has turned heads with his fearless power game. His booming serve and aggressive baseline play could complement Townsend’s doubles savvy perfectly.

Hard not to tear up listening to Taylor's D.C. champion's speech 🥹

Townsend will reign as the new WTA doubles No. 1 on Monday.#MubadalaDCCitiOpen pic.twitter.com/bnLOUy97x6
— Tennis Channel (@TennisChannel) July 26, 2025

On the opposite side, Rune has carved out another strong campaign with a Barcelona singles title and a 61% win rate in 2025, underscoring his ability to deliver on big stages. At just 21, his relentless baseline intensity and sharp return game remain his biggest weapons. His partner, Anisimova, has been in brilliant form, highlighted by a Wimbledon final appearance and her maiden WTA 1000 title in Qatar. With her newfound confidence and multiple Top 10 wins this year, she gives the pairing a legitimate edge.

Taylor Townsend/Ben Shelton vs. Holger Rune/Amanda Anisimova Head-to-Head Record

Taylor Townsend/Ben Shelton and Holger Rune/Amanda Anisimova do not have a head-to-head record yet.

At the 2025 #USOpen Holger Rune is partnering Amanda Anisimova for the Mixed Doubles competition where they are #4 seeds

They have drawn American duo Taylor Townsend and Ben Shelton. They play tomorrow on Louis Armstrong Stadium NB 1:30 pm. pic.twitter.com/MOweGMDUSj
— Holger Rune News (@running_rune) August 18, 2025

Taylor Townsend/Ben Shelton vs. Holger Rune/Amanda Anisimova Career Comparison

Townsend/Shelton	Category	Rune/Anisimova
2 / 0	Doubles Grand Slams	0 / 0
0 / 3	WTA Singles Titles	5 / 3
10 / 0	WTA Doubles Titles	0 / 0
No. 1 / No. 128	Current Doubles Ranking	–
No. 1 / No. 68	Career-Best Doubles Ranking	No. 176 / No. 386

Taylor Townsend/Ben Shelton vs. Holger Rune/Amanda Anisimova US Open 2025 Prediction

On paper, Townsend’s tactical doubles instincts combined with Shelton’s fearless serving and shot-making give the American team a well-rounded arsenal for mixed doubles success. Rune’s grinding baseline consistency and Anisimova’s recent surge make them more than capable of springing an upset, yet the chemistry and complementary skill set of Townsend and Shelton could prove decisive.

Good morning, @TaylorTownsend and @BenShelton 👋

We see the nails, Taylor 💅 pic.twitter.com/9Z46rBeA7u
— US Open Tennis (@usopen) August 19, 2025

Prediction: Taylor Townsend/Ben Shelton in straight sets.

Taylor Townsend/Ben Shelton vs. Holger Rune/Amanda Anisimova US Open 2025 Betting Odds

Townsend/Shelton enter as the clear favorites at 4/11, while Rune/Anisimova are slight underdogs at 2/1.

Here are the betting odds for Taylor Townsend/Ben Shelton vs. Holger Rune/Amanda Anisimova as per betting markets:

Taylor Townsend/Ben Shelton: 4/11

Holger Rune/Amanda Anisimova: 2/1

Mandatory Image Credit: Aaron Doster-Imagn Images

Ben Shelton

Holger Rune

Taylor Townsend

US Open 2025

Rudra Dubey

nfl

mma

I’m an academic turned sports writer from Raipur, India, specializing in the NFL, MMA, and tennis at The Playoffs. I previously wrote for Sportskeeda and hold a B.A. and M.A. in History. My journey into sports media began far from the field, rooted in the arts and sciences. Funny enough, I didn’t grow up a sports fan; I used to see it all as just noise. But a fateful writing job introduced me to the world of sports, and what began as a gig quickly became a passion. I understood those voices aren’t noise; they’re emotions of true sports fans, and now I am one of them, writing with the same energy I once questioned.