Jul 30, 2025; Toronto, ON, Canada; Stefanos Tsitsipas (GRE) plays a shot against Christopher O'Connell (AUS) during second round play at Sobeys Stadium. Mandatory Credit: Dan Hamilton-Imagn Images

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Stefanos Tsitsipas vs. Alexandre Muller Head-to-Head, Prediction and Betting Odds for US Open 2025 Round-1

Greek superstar looking to end his title drought in New York.

Jul 30, 2025; Toronto, ON, Canada; Stefanos Tsitsipas (GRE) plays a shot against Christopher O'Connell (AUS) during second round play at Sobeys Stadium. Mandatory Credit: Dan Hamilton-Imagn Images

Stefanos Tsitsipas will look to end his ordinary run of form against Alexandre Muller in the first round of the 2025 US Open on Tuesday. The Greek starlet hasn’t been his usual self for a long time now. At the recently concluded majors, Tsitsipas got eliminated in the second round of the French Open, and then couldn’t get past the first round in Wimbledon. The 27-year-old hopes to regain some of his lost momentum and end the year on a high note in New York.

On the other hand, Alexandre Muller isn’t having much of a better time on the court either. The Frenchman has a middling 20/20 record on the ATP Tour this year. Muller couldn’t move past Round-1 in Wimbledon and the French Open. As it stands, this match holds huge importance for both these men. It can prove to be a small ray of hope in a dark year. But who will prevail? Let’s find out using the most accurate betting odds provided by BetMGM.

Final ticket secured 🎟️

Alexandre Muller fights back from set down to defeat Munar 4-6 7-6 6-4 to reach his second tour-level final!#BOCHKTO pic.twitter.com/CRPrl5kYsC
— Tennis TV (@TennisTV) January 4, 2025

Stefanos Tsitsipas vs Alexandre Muller Head to Head

Stefanos Tsitsipas has a 2-0 record in the head-to-head against Alexandre Muller.

Tsistispas and Muller have faced each other twice so far. Interestingly both the times it was the Greek who came on top. In the first battle, Tsitsipas completed a 6-3, 7-5 straight sets win over the Frenchman. In Rome 2025 however, the match was decided by a second set tiebreaker.

Year	Event	Round	Winner	Score
2025	Rome	Round of 64	Stefanos Tsitsipas	6-2, 7-6(3)
2024	Shanghai	Round of 32	Stefanos Tsitsipas	6-3, 7-5

Stefanos Tsitsipas vs Alexandre Muller Career Comparison

Stefanos Tsitsipas	Category	Alexandre Muller
28	Current Rank	38
20/16	YTD W/L	20/20
1	YTD Titles	1
365/181	Career W/L	47/59
12	Career Titles	1

Stefanos Tsitsipas vs Alexandre Muller US Open 2025 Prediction

Despite Tsitsipas’ recent struggles, he remains much ahead of Muller – at least when it comes to his serve and forehand. However, the real trouble for the Greek is his backhand – a problem he is yet to fully solve. Certainly, Muller would look to take advantage of Tsitsipas’ weakness. In short, the entire match depends upon Muller’s ability to make inroads on the Tsitsipas, and the backhand success rate for the two-time Grand Slam finalist.

Prediction: Stefanos Tsitsipas in four sets.

Stefanos Tsitsipas vs Alexandre Muller US Open 2025 Betting Odds

Tsitsipas remains a firm favorite in this match. Here are the detailed odds per the highly accurate data from BetMGM.

Stefanos Tsitsipas win – 53/100
Alexandre Muller win – 29/20

Total Sets 3 – 7/5
Total Sets 4 – 8/5
Total Sets 5 – 9/4
Total Games >37.5 – 71/100
Total Games <37.5 – 19/20
Set 1 Winner Tsitsipas – 61/100
Set 1 Winner Muller – 5/4

(According to BetMGM: BetMGM offers exclusive promo codes, bonus deals and accurate odds for users upon signing up. Use BetMGM to ace your betting game in all sports!)

Mandatory Credit: Dan Hamilton-Imagn Images

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Sanskar Dubey

A passionate sports fan since childhood, it was always my dream to cover the peak of human potential. Baseball, Tennis, and Football (or Soccer) have been closest to my heart. From Rafael Nadal’s never-say-die attitude to Roger Federer’s beautiful backhand, I’ve seen it all. Prior to the Playoffs, I’ve worked in EssentiallySports and Pro Football and Sports Network.