Seahawks vs Rams Predictions, Odds, Picks & Best Bets for Thursday Night Football Week 16

The Seahawks battle the Rams as both teams look to gain advantage in the NFC West standings

Seahawks vs Rams Predictions, Odds, Picks & Best Bets for Thursday Night Football Week 16

The Seattle Seahawks host the Los Angeles Rams on Thursday Night Football (TNF) in this Week 16 encounter that could have major implications for the postseason seedings in the NFC. Both these NFC West teams are currently 11-3 on the season, with the winner of the division getting a direct entry to the postseason.

The Rams are slight favorites with -1.5 odds to win, and the over/under is projected at 44.5. Here are our best bets, same game parlays, and where to watch for this Week 16 NFC West divisional matchup.

Best Bet for Seattle Seahawks vs Los Angeles Rams

Best Bet: under 44.5 (-104)

Our best bet for the Seahawks vs Rams is total points under 44.5 (-104). (Sourced from FanDuel).

We like this bet mainly because both teams rank inside the top 5 in scoring defense. The Seahawks defense ranks second-best in the league, and is allowing just above 17 points per game, whereas the Rams are giving up just under 19 points per game.

Additionally, wide receiver Davante Adams has been the top target for Matthew Stafford in the end zone, but he is doubtful to play on Thursday due to a hamstring injury. This could severely hamper the Rams’ red zone offense. Furthermore, the weather is expected to be cold with an 84% chance of rain.

Given the overall factors mentioned above, we are backing the game total to be under 44.5 at around -104.

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Same-Game Parlay Picks for Seahawks vs Rams

This is our pick for a 3-leg same game parlay for the Seahawks vs Rams Thursday Night Football game (Sourced from FanDuel).

Jaxon Smith-Njigba Anytime TD Scorer: +110
Puka Nacua 8+ Receptions: -132
Matthew Stafford 2+ Passing Touchdowns: +100

Combined Odds: +480

We like the above 3-leg parlay since all three bets have merit based on recent performances. Jaxon Smith-Njigba has been, without a doubt, the best receiver not only for the Seahawks but also in the league this year. He has already hauled in 9 touchdown catches from 14 games, while remaining one of Sam Darnold’s top targets in the end zone. Smith-Njigba has 4 touchdowns in his last 4 games.

Puka Nacua has taken over as the Rams’ number one wide receiver, and his connection with Matthew Stafford has stood out once again this season. Nacua has been averaging 7 or more receptions in 4 of his last 5 games, and with Davante Adams unlikely to feature, Nacua’s targets should only increase.

Coming to the quarterback play, Stafford is miles ahead of most of the other quarterbacks in the league this season. He leads the league with 37 touchdown passes and has thrown multiple touchdowns in 12 of his 14 games, including the last 8 in a row.

If you’re looking for a complete guide to the best NFL betting sites, we’ve got you covered

This will be the first-ever Thursday Night game between two teams with 11+ wins 🔥 pic.twitter.com/mwbs3g4xEk
— NFL on Prime Video (@NFLonPrime) December 16, 2025

Seahawks vs Rams Game Predictions by Market

Apart from our best bet, this is what we feel about the moneyline, spread, and total for the Seahawks vs Rams game.

Moneyline Prediction

As far as the line is concerned, both the Seahawks and the Rams have -108 odds to win the game. The Seahawks hold the edge, considering the home advantage as well as the colder weather.

Spread Prediction

The Rams are the slight favorites with a -1.5 spread at +100 over the Seahawks. However, the Seahawks are divisional rivals and playing at home. The Seahawks are 10-4 against the spread this year.

Over/Under (Total) Prediction

The over/under for the total points in the Seahawks vs Rams game is set at 44.5. Both teams possess top 5 offenses and defenses. However, this being a divisional rivalry matchup, the game can be expected to be a low-scoring one. The last game between these two teams in Week 11 ended with a points total of 40.

Seahawks vs Rams Odds

Here, we take a look at the latest Seahawks vs Rams odds from a couple of our favourite sportsbooks, namely, FanDuel and BetMGM.

Spread	FanDuel	BetMGM
Seattle Seahawks	+1.5 (-122)	+1.5 (-124)
Los Angeles Rams	-1.5 (+100)	-1.5 (+102)

Moneyline	FanDuel	BetMGM
Seattle Seahawks	-108	-108
Los Angeles Rams	-108	-110

Total	FanDuel	BetMGM
Over 44.5	-104	-109
Under 44.5	-118	-112

Trends to Know for Seahawks vs Rams

ATS trend: The Seahawks are 4-3 in their last 7 home games.
ATS trend: The Los Angeles Rams are 4-2 in their last 6 away games.
Total trend: The over is 4–3 in the Seahawks’ last 7 road games.

Thursday 🚨

These Seahawks helmets are INSANE 🤯 pic.twitter.com/jRVTmmusZd
— Seattle ON Tap (@SeattleONTap) December 15, 2025

Latest Injuries for Seahawks vs Rams

The Rams are currently suffering injuries on offense to key players such as Davante Adams and Braden Fiske, both of whom have not practiced this week and remain doubtful to play on Thursday. Tight end Tyler Higbee has also been limited in practice this week.

Left tackle Charles Cross is the only significant injury concern for the Seahawks at the moment. Cross is suffering from a hamstring issue and has not practiced this week.

Weather Report for Seahawks vs Rams

The forecasted weather for Thursday Night Football is 39 degrees. However, the RealFeel temperature on Accuweather is 33 degrees. There will be an 84% chance of rain, and wind speed is forecasted at 10 mph from the South-West, with gusts up to 31 mph.

What time is the Seahawks vs Rams TNF Game?

The Seattle Seahawks will take on the Los Angeles Rams on Thursday Night Football with kick-off set at 8:15 p.m. ET on Thursday, December 18, 2025.

Where is the Seahawks vs Rams game being played?

The Seahawks vs Rams game will be played at Lumen Field in Seattle, Washington, the home of the Seattle Seahawks.

How can I watch the Seahawks vs Rams?

Being a Thursday Night Football game, the rights for the TNF package belong to Amazon Prime Video. Therefore, the Seahawks vs Rams will be telecast on Prime Video. The game can also be seen locally on FOX 11 (LA) or My Network TV (LA).

Live streaming options include Fubo, YouTube TV, and Hulu + Live TV, while streaming exclusively on mobiles or tablets is available on NFL+ as well.

The above odds are sourced from FanDuel. Use FanDuel to ace your betting game in all sports!

Mandatory Credit: Brett Davis-Imagn Images

Devavrat Kulkarni

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I am a content writer for the NFL team, and joined The Playoffs after working with Sportskeeda and NFL Analysis as an NFL writer. After starting my professional career as a French-to-English translator, working as a content writer is a new adventure for me. I started out in the sports media field for two main reasons: my love for sports in general, especially the NFL, NBA, and Tennis, as well as my passion for writing. The best part of this job is that I get to write a variety of pieces with the freedom to explore content from various angles. It also enables me to stay up to date with the sporting world, which otherwise can be difficult to do in the day-to-day grind. In a world full of chaos, sports unite and entertain like nothing else!