The NFC Divisional Round ignites with a heated rivalry rematch as the top-seeded Seattle Seahawks (14-3) host the sixth-seeded San Francisco 49ers (12-5) at Lumen Field on Saturday, home of the Seahawks.
Fresh off their first-round bye, the Seahawks clinched the NFC West title and No. 1 seed with a dominant 13-3 shutout of the 49ers in Week 18, showcasing their elite defense (No. 1 in points allowed) under Mike Macdonald and reliable play from QB Sam Darnold, supported by stars like Jaxon Smith-Njigba and a potent run game.
The resilient 49ers, who upset the Eagles 23-19 on Wild Card Weekend, enter as road warriors (8-2 away) but face challenges with key injuries, including a season-ending Achilles tear for TE George Kittle. This third clash of the season, after 49ers’ Week 1 win, promises intensity, with Seattle favored by 7.5 points in a battle for NFC Championship berth.
With that said, let us look at Seahawks vs 49ers Touchdowns prop for this Divisional round matchup.
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Jaxson Smith Njigba Anytime TD vs San Francisco 49ers (-120)
The Seahawks’ superstar WR led the NFL with 1,793 receiving yards (119 catches) and notched 10 TDs in 2025, earning All-Pro honors as a red-zone nightmare. In their Week 18 rout of the 49ers (13-3 win), he dominated with 6 catches for 84 yards, showing he feasts on this secondary despite no TD that game.
San Francisco’s defense allowed 15 receiving TDs to WRs this season, vulnerable in the passing game. With home-field edge, Sam Darnold’s trust, and playoff intensity, JSN’s target share and explosiveness make -120 excellent value, as he’s primed to score in this rivalry rematch.
Zach Charbonnet Anytime TD vs San Francisco 49ers (-120)
The Seahawks’ powerful RB2 exploded for 12 rushing TDs (tied for 5th-6th in NFL) on 184 carries in 2025, emerging as the red-zone hammer with multiple scores in recent hot stretches. In Week 18’s dominant 13-3 win over the 49ers, he rushed for 74 yards and a 27-yard TD, forcing missed tackles and punishing their front.
San Francisco’s run defense surrendered 13 rushing TDs (mid-pack vulnerability) and struggled against Seattle’s ground attack in both meetings. With home momentum, goal-line opportunities, and Charbonnet’s short-yardage trust, -120 delivers excellent value, primed to punch one in again.
Christian McCaffrey Anytime TD vs Seattle Seahawks (-120)
The 49ers’ superstar RB posted 17 total TDs in 2025 (10 rushing, 7 receiving) on 311 carries for 1,202 yards and 102 catches for 924 yards, staying healthy all season and exploding for 2 receiving TDs in the Wild Card win over Philly. He scored in multiple late-season games and thrives in high-volume, red-zone roles.
Despite Seattle’s elite run defense (No.3 in rushing defense on league-best 9 rushing TDs conceded, held CMC to 23 rush yards in Week 18), his receiving threat (vulnerable secondary allowed receiving TDs) and playoff pedigree (recent multi-TD output) makes it highly probable for him to get a TD, especially with 49ers’ motivation in this rivalry rematch.
Kenneth Walker Anytime TD vs San Francisco 49ers (+115)
The Seahawks’ explosive lead RB rushed for 1,027 yards (4.6 YPC) on 221 carries with 5 TDs in 2025, showcasing big-play ability and red-zone involvement. In Week 18’s dominant 13-3 win over the 49ers, he torched them for 97 rushing yards (plus 36 receiving) on 16 carries, setting the tone without scoring, but proving he exploits their front (allowed 13 rushing TDs league-wide, 4.3 YPC condeded)
49ers’ run defense is solid but vulnerable to chunk plays at home/road, and with Seattle’s ground-heavy scheme, home momentum, and goal-line chances in a rivalry rematch, Walker’s explosiveness makes +115 excellent upside value, he’s due to punch one in after close calls.
Anytime TD Betting Card for Seattle Seahawks vs San Francisco 49ers
Here is a quick recap for the Seahawks vs 49ers anytime touchdown scorers and their odds as sourced via BetMGM.
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