Seahawks vs 49ers highlights the NFC Divisional Round with a classic NFC West rivalry clash as the top-seeded Seattle Seahawks (14-3) welcome the sixth-seeded San Francisco 49ers (12-5) to Lumen Field on Saturday, January 17, 2026.
The Seahawks enter rested after securing the No.1 seed and NFC West crown, bolstered by their league-leading defense that shut out opponents in key stretches and a balanced offense featuring Sam Darnold at quarterback, explosive receivers, and a committed ground attack.
The 49ers arrive battle-tested, having advanced past the Eagles in a gritty Wild Card victory, relying on their resilient core despite injuries, including the season-ending loss of tight end George Kittle. This marks the third meeting between the teams this season, following San Francisco’s Week 1 win and Seattle’s Week 18 near shutout.
Best Bet for Seattle Seahawks vs San Francisco 49ers
Best Bet:
Our best bet for the Seahawks vs 49ers is Brock Purdy over 0.5 Interceptions thrown: (-160), (Sourced from BetMGM)
Seattle’s elite defense led the NFL in points allowed (17.2 PPG) and forced 18 interceptions this season (1.1 per game), ranking among the top units in creating turnovers through pressure and coverage. Purdy has thrown 10 INTs in just 9 regular-season games (3.5% rate), including 2 in Week 1 at Seattle and 1 in Week 18’s 13-3 loss to them, showing vulnerabilities against the aggressive secondary.
In their two 2025 meetings, Purdy was picked off 3 times total, often under duress from Seattle’s pass rush (highest pressure rate of his career in Week 1). Facing a rested, No.1- seeded defense that’s historically tough on him (6 career INTs vs Seahawks), plus San Francisco’s injury-hit offense forcing more passes, expect at least one mistake in this high-stakes rivalry matchup. If that’s not enough to convince you, Purdy threw two picks in his last game against the Eagles, whose defense is a lot similar to Seattle’s.
Same-Game Parlay Picks for Seahawks vs 49ers
Here are our picks for a 3-leg same game parlay for the Seahawks vs 49ers Divisional round game (Sourced from BetMGM).
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Seattle boasts the NFL’s No.1 defense (17.2 PPG allowed, top in points and yards), limiting opponents to just 20 passing TDs all season (1.2 per game average). In their two 2025 meetings, Purdy threw exactly 2 TDs in Week 1 but zero in Week 18’s 13-3 near shutout loss, averaging 1.0 passing TD against this elite unit.
San Francisco’s offense faces major hurdles with George Kittle’s season-ending Achilles tear (from Wild Card vs Eagles), thinning the passing game and red-zone options. Purdy’s overall 20 TDs came in limited 9-game regular season, but against Seattle’s aggressive pressure and turnover-forcing secondary, expect a grind-it-out, low-scoring affair reliant on run game and defense, making under 1.5 excellent value.
The 49ers’ elite RB delivered 17 total touchdowns in 2025 (10 rushing, 7 receiving) across 311 carries for 1,202 yards and 102 catches for 924 yards, maintaining full health and consistency with multi-TD games late in the season including 2 receiving scores in the Wild Card win over Philadelphia. His red-zone dominance and versatile usage make him San Francisco’s go-to scorer.
Despite Seattle’s top-ranked run defense (No.1 in points allowed, held CMC to 23 rush yards in Week 18), their secondary allowed 12 receiving TDs to RBs/TEs, exposing vulnerabilities in coverage. With Kittle sidelined, McCaffrey’s target share should rise in the passing game boosting his scoring chances in short-yardage and checkdown situations, making this a great bet. Don’t be surprised if 49ers take out another trick play from their bag, using Jauan Jennings as their QB with McCaffrey as the recipient, yet again.
The Seahawks‘ superstar WR led the NFL with 1,793 receiving yards on 119 catches and notched 10 TDs in 2025, earning All-Pro honors as a red-zone nightmare with explosive plays (27 of 20+ yards). In their two meetings in 2025, he posted 15 catches for 208 yards (including 6 for 84 in the Week 18 13-3 shutout win), dominating despite no TD, proving he consistently torches this secondary.
San Francisco allowed 29 passing TDs this season and are one of the worst pass defense teams in the NFL ranking 25th, allowing 232.4 yards per game throughout the regular season. With home field advantage, Darnold’s trust as the go-to receiver, and playoff intensity boosting red-zone looks, JSN’s high target share and big-play ability could get him at least a TD in this rivalry game.
Here is a look at the line, spread, and points Over/Under for the Seahawks vs 49ers Divisional round game, as per BetMGM.
Moneyline Prediction
The moneyline for this game sits heavily in the favor of the Seahawks at (-350), while the 49ers are the (+280) underdogs. This game is expected to be more of a lopsided matchup, especially since the 49ers are extremely short handed with multiple key players out of the starting lineup. The Seahawks on the other hand are full heathy, the No.1 seed, and are sound defensively and offensively, which could be too much for San Francisco to handle.
Over/Under (Total) Prediction
The over/under for the total points in the Seahawks vs 49ers game is set at 45. Both the times these two teams squared off in the regular season, neither could score above 20 points. In their first matchup, the final score ended in 49ers’ favor 17-13. And the second time they faced each other, the final score was 13-3 in Seattle’s favor. We do not expect much to change in this game, which makes us pick the Under for this rivalry Divisional round matchup.
The average total point scored per game across both games in the regular season for Seahawks vs 49ers was 23.0 points, which proves that under has been the trend for these two teams.
Spread Prediction
The Seahawks are a heavy favorite with a -7 spread over the 49ers. Seattle’s No.1 seed positioning gave them an extra week’s rest, and the 49ers are also very short handed going into this matchup. This game could get out of hand very early, but the 49ers have shown that they are resilient and will not go away without putting up a fight.
Seahawks vs 49ers Odds
Here, we take a look at the latest Seahawks vs 49ers odds from a couple of our favourite sportsbooks, namely, FanDueland BetMGM.
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Trends to Know for Seahawks vs 49ers
The Seahawks are 12-5 against the spread this season.
The 49ers are 11-7 against the spread this season.
The OVER is 10-8 in the 49ers’ games this season.
The OVER is 9-8 in the Seahawks’ games this season.
The 49ers are 8-2 against the spread on the road this season.
The Seahawks are 4-4 against the spread at home this season.
Latest Injuries for Seahawks vs 49ers
Latest Injury report for the Seahawks
Coby Bryant – Questionable
Tory Horton – Injured reserve
Cody White – Injured reserve
Charles Cross – Questionable
Elijah Arroyo – Questionable
Latest Injury report for the 49ers
Dee Winters – Out
Rick Pearsall – Out
George Kittle – Out
Fred Warner – Injured Reserve
Luke Gifford – Out
Ji’Ayir Brown – Questionable
Jacob Cowing – Injured Reserve
Tatum Bethune – Injured Reserve
Weather Report for Seattle Seahawks vs San Francisco 49ers
Clear skies are expected for kickoff, with temperatures in the high 40s (around 47-49 degrees F). Winds will be minimal, sustained breezes of just 4 mph and gusts peaking at 9 mph, blowing North-Northeast from end zone to end zone.
This calm, mild condition should have zero meaningful impact on the game, neither favoring the Seahawks, who have the home-field advantage, nor the 49ers, who are very accustomed to similar cool weather. The forecast promises ideal, straightforward playing conditions for both teams.
What time is the Seahawks vs 49ers Divisional Game?
The matchup between the Seahawks vs 49ers Divisonal round game will kick off at 8:00 p.m. ET, slated for a primetime showdown.
Where is the Seahawks vs 49ers game being played?
The Seahawks take on the 49ers in the second Divisional game on Saturday at Lumen Field, Seattle, home of the Seahawks.
How can I watch the Seattle Seahawks vs San Francisco 49ers?
The Seattle Seahawks vs San Francisco 49ers Divisional round matchup will be broadcasted live on FOX. Fans can also catch the action through streaming services using platforms like Fubo.
(According to BetMGM: BetMGM offers exclusive promo codes, bonus deals and accurate odds for users upon signing up. Use BetMGM to ace your betting game in all sports!)
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