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Saints vs Patriots Predictions, Odds and Best Bets For Week 6 of the 2025-26 NFL Season

Devavrat Kulkarni

The Saints take on the Patriots in New Orleans this week

American Football / NFL
12/10/2025 – 18:00
New Orleans Saints
VS
18:00
12/10/2025
New England Patriots
Odds updated on October 10, 2025 at 1:52 pm

Saints vs Patriots Predictions, Odds and Best Bets For Week 6 of the 2025-26 NFL Season

The New Orleans Saints are fresh off their first win of the season and will look to take the confidence into their week 6 matchup against the New England Patriots. The Saints come into the game with a 1-4 record, whereas the Patriots are 3-2 after their win over the Bills last week.

Game Details:

  • Time: 1:00 p.m. ET
  • Date: Sunday, October 12, 2025
  • Location: Caesars Superdome, New Orleans, Louisiana
  • TV Channel: CBS
  • Streaming: Paramount Plus / Fubo

Recommended bets and updated odds

Recommended BetsFanDuelBetMGM
Stefon Diggs 60+ Receiving Yards-120-106
Chris Olave 60+ Receiving Yards-102-105
Patriots Moneyline -180-190
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Analysis and Rationale

Stefon Diggs seems to have found chemistry with quarterback Drake Maye over the past couple of games. He has over 100 receiving yards in the week 4 and week 5 games against the Panthers and Bills. The Saints have a good secondary, so another 100-yard performance could be difficult. 

The Saints may have to put the ball in the air more against the Patriots, who are stronger against the run on defense. Wide receiver Chris Olave has been consistently putting up over 50 receiving yards a game.

Both the Patriots and the Saints won their respective games in week 6. However, New England has been playing well ever since its week 1 loss to the Raiders. Additionally, their win last week came against the Bills, one of the toughest opponents in the league, while the Saints beat the struggling Giants. 

Saints vs Patriots Prediction

The Patriots are starting to look like a contender in the AFC East under Mike Vrabel. They are just one game off the Bills, and second-year quarterback Drake Maye has elevated his game from his rookie season. 

Offensively, the Saints are struggling to put points on the board, averaging just 18.4 per game, while the Patriots are averaging 25 a game. On defense, it is a similar story as the Patriots are allowing just over 20 points per game, while the Saints are giving up 27. 

Prediction: New England Patriots to win. 

Week 6 Saints vs Patriots Betting Odds and Spread

The moneyline and spread show that the New England Patriots are the favorites in this matchup against the New Orleans Saints. (Sourced from FanDuel)

MoneylineSpreadTotal Points
New Orleans Saints+154+3.5 (-115)O 45.5 (-115)
New England Patriots-184-3.5 (-105)U 45.5 (-105)

Saints vs Patriots Best Bets

Here are the over/under and best player bets for the New Orleans Saints and the New England Patriots, as per FanDuel.

New Orleans Saints Over/Under Odds

Below are some of the best over/under bets for the New Orleans Saints.

Over/ Under BetsOver Under
Spencer Rattler Passing Touchdowns1.5 (+116)1.5 (-154)
Chris Olave Total Receptions6.5 (-118)6.5 (-112)
Rashid Shaheed Total Receptions3.5 (-158)3.5 (+118)
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New Orleans Saints Best Player Bets

Below are some of the best player bets for the New Orleans Saints.

  • Spencer Rattler 200+ Passing Yards: -154
  • Chris Olave 60+ Receiving Yards: -102
  • Alvin Kamara 40+ Rushing Yards: -122

If you’re looking for a complete guide to the best NFL betting sites, we’ve got you covered 

New England Patriots Over/Under Odds

Below are some of the best over/under bets for the New England Patriots.

Over/ Under BetsOver Under
Drake Maye Pass Attempts30.5 (-106)30.5 (-122)
Stefon Diggs Total Receptions4.5 (-158)4.5 (+118)
Rhamondre Stevenson Rushing Yards43.5 (-108)43.5 (-122)
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New England Patriots Best Player Bets

Below are some of the best player bets for the New England Patriots.

  • Drake Maye 225+ Passing Yards: -144
  • Stefon Diggs 60+ Receiving Yards: -120
  • Rhamondre Stevenson Under 11.5 carries: -108

The above odds are sourced from FanDuel. Use FanDuel to ace your betting game in all sports!

FAQs

What is the over/under for total points for the Saints vs Patriots game?

The over/under for total points in the Saints vs Patriots game is set at 47.5.

What is the point spread for the Saints vs Patriots game on Sunday?

The Patriots come into the game as 3.5-point favorites over the Saints.

What is the moneyline for the Saints vs Patriots game in week 2?

The Patriots are the favorites with a moneyline of -180, while the Saints are the underdogs at +152.

Mandatory Credit: Gregory Fisher-Imagn Images

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I am a content writer for the NFL team, and joined The Playoffs after working with Sportskeeda and NFL Analysis as an NFL writer. After starting my professional career as a French-to-English translator, working as a content writer is a new adventure for me. I started out in the sports media field for two main reasons: my love for sports in general, especially the NFL, NBA, and Tennis, as well as my passion for writing. The best part of this job is that I get to write a variety of pieces with the freedom to explore content from various angles. It also enables me to stay up to date with the sporting world, which otherwise can be difficult to do in the day-to-day grind. In a world full of chaos, sports unite and entertain like nothing else!

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