Los Angeles Rams vs Indianapolis Colts Preview, Prediction, and Betting Odds – Week 4 2025-26 NFL Season

The Los Angeles Rams will take on the Indianapolis Colts for Week 4’s NFC vs AFC matchup, at SoFi Stadium. Both the teams are coming in hot, with the Colts unbeaten so far with a flawless 3-0 start, leading in the AFC South division. Meanwhile, the Rams are coming off a heartbreaking loss but have shown that they are one of the best teams in the NFL, pushing the Super Bowls champs to the brink of defeat.

taking flight to LA. ✈️ pic.twitter.com/ZcNIGAGY0A
— Indianapolis Colts (@Colts) September 27, 2025

This matchup will be the toughest matchup so far for the unbeaten Colts, who are red hot to start this season with Daniel Jones leading the way.

Recommended Bets	FanDuel	BetMGM
Jonathan Taylor Anytime TD	-220	-200
Kyren Williams Anytime TD	-200	-190
Daniel Jones Under 0.5 INTs thrown	-140	-165

FanDuel

High total bonus ceiling

Daily second-chance bet protection

No promo code required

$150

Welcome offer

Bet $5 & Get $150 in Bonus Bets

Click to reveal code

COPIED

F A N D U V I P

Claim now

New customers only. Must be 21+ in most jurisdictions, but 18+ in DC, KY, and WY. Offer is valid only in eligible regulated states/jurisdictions and not available in AR; void where prohibited. First online real-money wager only; cashed-out or bonus-funded bets are excluded.

Rationale and Analysis

The first bet including Jonathan Taylor to score a TD anytime is a solid bet as Taylor scored 3 TDs in his last outing against the Tennessee Titans, and while the Rams are way better defensively, Taylor is the focal point of the Colts offense and we expect him to score at least one TD.

Similarly, Kyren Williams is also favored to score a TD anytime, as he can not only rush with the ball, but can also catch the ball and score as we saw him do against the Eagles. He has one receiving TD and a rushing TD this season, making him a threat to score at any point of time.

Daniel Jones is having an insane season and while the Rams defense is extremely tough, Jones may not slow down in this game too. His form is immaculate this season and is currently playing for a MVP front runner. Jones has been highly accurate this season with an insane 71.6 pass completion percentage and zero interceptions. We believe that this will continue and it therefore a safe bet.

Rams vs Colts Preview

The Los Angeles Rams (2-1) host the undefeated Indianapolis Colts (3-0) in a Week 4 showdown at SoFi Stadium on Sunday, September 29, 2025. The Rams boast a top-five offense and elite defense, powered by Matthew Stafford and Puka Nacua’s NFL leading 333 receiving yards, on pace to make history with the amount of receptions he’s already made.

The Colts meanwhile, led by Daniel Jones’ efficient passing and a stingy red-zone defense allowing 5 passing TDs, seek their first road win. Their offense ranks 2nd and they will be testing LA’s defense, who ranks 6th overall.

Rams vs Colts Prediction

We expect the Los Angeles Rams to take home the victory and spoil the Colts’ undefeated run, simply because of the Rams having a better offensive unit than the Colts and their home field advantage. While the Colts have been impressive, the have not been tested yet this season, playing against the Broncos (nearly lost the game), the Titans, and the Dolphins, who are all struggling to find their groove.

Prediction: Rams win the game 27-24

No stranger to Sundays. pic.twitter.com/1v5oXjjg6L
— Los Angeles Rams (@RamsNFL) September 25, 2025

Rams vs Colts Betting Odds

Here are the best bets and over/under betting odds for the L.A. Rams and the Indianapolis Colts, as per BetMGM

L.A. Rams Over/Under Odds

Below are over/under odds for the L.A. Rams, according to BetMGM

Over/Under Bets	Over	Under
Matthew Stafford Passing Yards	252.5 (-115)	252.5 (-115)
Puka Nacua Receiving Yards	87.5 (-115)	87.5 (-115)
Kyren Williams Rushing Yards	71.5 (-115)	71.5 (-115)

L.A. Rams Best Player Bets

Here are some of the best player bets for the L.A. Rams according to BetMGM

Puka Nacua over 6.5 receptions made: -190
Matthew Stafford under 22.5 pass completions: -130
Kyren Williams Anytime TD scorer: -190

BetMGM

All in one gambling website

Reputable gambling name

Multiple betting features including live streaming

$1,500

Welcome offer

Get up to $1,500 Back in Bonus Bets

Click to copy code

COPIED

TPOVIP

Claim now

21+. AZ/CO/IL/IN/IA/KS/LA/MD/MA/MI/NJ/OH/PA/TN/ VA/WV/WY only. Offer not available in DC/MS/NV/NY/PR. New customers only. Qualifying deposit (min $10) and first real money wager required. If qualifying bet settles as a loss, user is refunded 100% in non-withdrawable bonus bets up to $1,500. Full T&Cs can be found on betmgm.com.

Indianapolis Colts Over/Under Odds

Below are over/under odds for the Indianapolis Colts, as per BetMGM

Over/Under Bets	Over	Under
Daniel Jones Passing Yards	216.5 (-115)	216.5 (-115)
Michael Pittman Jr. Receiving Yards	50.5 (-115)	50.5 (-118)
Jonathan Taylor Rushing Yards	90.5 (-115)	90.5 (-115)

Indianapolis Colts Best Player Bets

Here are some of the best player bets for the Indianapolis Colts, as per BetMGM

Jonathan Taylor Anytime TD scorer: -200
Daniel Jones under 1.5 passing TDs: -210
Tyler Warren over 4.5 receptions: -130

Rams vs Colts Spread and Betting Odds

Looking at the spread and the moneyline, the Rams are the favorites to win this matchup against the Colts, as per BetMGM

Teams	Spread	Total Points	Moneyline
Colts	+3.5 (-115)	49.5 (-110)	+155
Rams	-3.5 (-105)	49.5 (-110)	-190

BetMGM

All in one gambling website

Reputable gambling name

Multiple betting features including live streaming

$1,500

Welcome offer

Get up to $1,500 Back in Bonus Bets

Click to copy code

COPIED

TPOVIP

Claim now

(According to BetMGM: BetMGM offers exclusive promo codes, bonus deals and accurate odds for users upon signing up. Use BetMGM to ace your betting game in all sports!)

FAQs

Who is favored to win between the Rams and the Colts?
The Rams are 3.5-points favorites to win the matchup against the Colts.

What is the over/under total for the game?
The over/under for total points is set at 49.5.

What is the predicted score for the Rams vs Colts game?
We predict that the Rams will edge out the Colts 27-24

Eric Divakaran

nba

nfl

mma

I cover the National Football League and things cannot get better than that. I always dreamed to play football or basketball professionally since I’m built like a Running Back. But now that I can’t, since I’m technically in the “Unc” age, I thought why not pick a career in sports industry? So here I am, doing what I love, and hoping that the Commanders win the Super Bowl. I give love to players when it’s due, but can be critical about their performances at the same time. Enough about me, now let my articles do all the talking.